Patents by Inventor Phillip R. Cunningham

Phillip R. Cunningham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance
    Patent number: 8367319
    Abstract: Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of the present invention may be used to identify antibiotics to treat a large number of human pathogens through the use of genetically engineered rRNA genes from a variety of species. The invention further provides novel plasmid constructs to be used in the methods of the invention.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: February 5, 2013
    Assignee: Wayne State University
    Inventor: Phillip R. Cunningham
  • METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF ANTIBIOTICS THAT ARE NOT SUSCEPTIBLE TO ANTIBIOTIC RESISTANCE
    Publication number: 20110256533
    Abstract: Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of the present invention may be used to identify antibiotics to treat a large number of human pathogens through the use of genetically engineered rRNA genes from a variety of species. The invention further provides novel plasmid constructs to be used in the methods of the invention.
    Type: Application
    Filed: April 30, 2010
    Publication date: October 20, 2011
    Inventor: PHILLIP R. CUNNINGHAM
  • Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance
    Patent number: 7081341
    Abstract: Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of the present invention may be used to identify antibiotics to treat a large number of human pathogens through the use of genetically engineered rRNA genes from a variety of species. The invention further provides novel plasmid constructs to be used in the methods of the invention.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: July 25, 2006
    Assignee: Wayne State University
    Inventor: Phillip R. Cunningham
  • Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance
    Publication number: 20040137011
    Abstract: Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of the present invention may be used to identify antibiotics to treat a large number of human pathogens through the use of genetically engineered rRNA genes from a variety of species. The invention further provides novel plasmid constructs to be used in the methods of the invention.
    Type: Application
    Filed: July 1, 2003
    Publication date: July 15, 2004
    Inventor: Phillip R. Cunningham