Abstract: Compositions are provided including a Mu opioid receptor antagonist, and an ?2-adrenergic receptor agonist; or an ?1 adrenergic receptor antagonist, together with one or more of a mu (or opioid receptor subtype) antagonist or agonist, (2) a vasopressor, (3) an anticholinergic agent and/or cholinergic agents, (4) a combined alpha-1 adrenergic antagonist and anticholinergic, (5) a paralytic or muscle relaxant, (6) a respiratory accelerant, (7) a GABA complex antagonist, (8) an anti-seizure/membrane stabilizer agent, (9) an ?1 adrenergic receptor agonist, and/or (10) an ?2 adrenergic receptor agonist; and a pharmaceutically acceptable carrier. Also provided are methods of preventing or reversing effects in a subject (including muscle and chest wall rigidity, laryngospasm, WCS, and/or respiratory depression) arising from intentional or accidental opioid or opiate exposure.

Abstract: Methods are provided of preventing or reversing negative effects in a subject, which effects arise from intentional or accidental opioid or opiate exposure coupled with intentional or accidental stimulant exposure, or interactive effects of these classes of drugs (e.g. Stimulant and Synthetic Opioid Induced Vascular Events (SSOIVE) from concurrent opioid and stimulant overdose). The methods involve administering to the subject a pharmaceutical composition including therapeutically effective amounts of an ?1 adrenergic receptor antagonist, together with one or more of a mu (or opioid receptor subtype) antagonist or agonist, an anticholinergic agent and/or cholinergic agents, a combined alpha-1 adrenergic antagonist and anticholinergic, a paralytic or muscle relaxant, a GABA complex antagonist, an anti-seizure/membrane stabilizer agent, an ?2 adrenergic receptor agonist and/or a beta blocker; and a pharmaceutically acceptable carrier.

Abstract: Compositions are provided including a Mu opioid receptor antagonist, and an ?2-adrenergic receptor agonist; or an ?1 adrenergic receptor antagonist, together with one or more of a mu (or opioid receptor subtype) antagonist or agonist, (2) a vasopressor, (3) an anticholinergic agent and/or cholinergic agents, (4) a combined alpha-1 adrenergic antagonist and anticholinergic, (5) a paralytic or muscle relaxant, (6) a respiratory accelerant, (7) a GABA complex antagonist, (8) an anti-seizure/membrane stabilizer agent, (9) an ?1 adrenergic receptor agonist, and/or (10) an ?2 adrenergic receptor agonist; and a pharmaceutically acceptable carrier. Also provided are methods of preventing or reversing effects in a subject (including muscle and chest wall rigidity, laryngospasm, WCS, and/or respiratory depression) arising from intentional or accidental opioid or opiate exposure.

Abstract: Methods are described to reduce risk of or prevent wooden chest syndrome or other respiratory effects arising from exposure to fentanyl or a fentanyl analog, for instances inpatients receiving medically assisted treatment (MAT) for Opioid Use Disorder (OUD) or who are receiving analgesia and pain management with F/FAs. Pharmaceutical compositions for use in such methods are described.

Abstract: Methods are provided of preventing or reversing negative effects in a subject, which effects arise from intentional or accidental opioid or opiate exposure coupled with intentional or accidental stimulant exposure, or interactive effects of these classes of drugs (e.g. Stimulant and Synthetic Opioid Induced Vascular Events (SSOIVE) from concurrent opioid and stimulant overdose). The methods involve administering to the subject a pharmaceutical composition including therapeutically effective amounts of an ?1 adrenergic receptor antagonist, together with one or more of a mu (or opioid receptor subtype) antagonist or agonist, an anticholinergic agent and/or cholinergic agents, a combined alpha-1 adrenergic antagonist and anticholinergic, a paralytic or muscle relaxant, a GABA complex antagonist, an anti-seizure/membrane stabilizer agent, an ?2 adrenergic receptor agonist and/or a beta blocker; and a pharmaceutically acceptable carrier.

Abstract: Pharmaceutical compositions are provided including therapeutically effective amounts of an ?1 adrenergic receptor antagonist, together with one or more of (1) a mu (or opioid receptor subtype) antagonist or agonist, (2) a vasopressor, (3) an anticholinergic agent and/or cholinergic agents. (4) a combined alpha-1 adrenergic antagonist and anticholinergic (e.g. droperidol), (5) a paralytic or muscle relaxant, (6) a respiratory accelerant, (7) a GABA complex antagonist, (8) an anti-seizure/membrane stabilizer agent, (9) an ?1 adrenergic receptor agonist, and/or (10) an ?2 adrenergic receptor agonist; and a pharmaceutically acceptable carrier. Also provided are methods of preventing or reversing effects in a subject (including muscle and chest wall rigidity, laryngospasm, WCS, and/or respiratory depression) arising from intentional or accidental opioid or opiate exposure, involving administering to the subject such a pharmaceutical composition.

Abstract: Pharmaceutical compositions are provided including therapeutically effective amounts of an ?1 adrenergic receptor antagonist, together with one or more of (1) a mu (or opioid receptor subtype) antagonist or agonist, (2) a vasopressor, (3) an anti-cholinergic agent and/or cholinergic agents, (4) a combined alpha-1 adrenergic antagonist and anticholinergic (e.g. droperidol), (5) a paralytic or muscle relaxant, (6) a respiratory accelerant, (7) a GABA complex antagonist, (8) an anti-seizure/membrane stabilizer agent, (9) an ?1 adrenergic receptor agonist, and/or (10) an ?2 adrenergic receptor agonist; and a pharmaceutically acceptable carrier. Also provided are methods of preventing or reversing effects in a subject (including muscle and chest wall rigidity, laryngospasm, WCS, and/or respiratory depression) arising from intentional or accidental opioid or opiate exposure, involving administering to the subject such a pharmaceutical composition.