Abstract: A method throttles display of electronic messages. The process displays a list of entries in an email application. The list of entries includes a first electronic message, a first message cluster, and a second message cluster. The process detects the occurrence of a cluster display trigger event for the first message cluster. The trigger event is one of: detection of passage of a predetermined amount of time since refreshing display of the first message cluster, an occurrence of a particular time of day, an occurrence of a predetermined date, or receipt by the first message cluster of a predefined number of new electronic messages since previously refreshing the display of the list. In response to the detected trigger event, the process refreshes the display of the list of entries, including re-ranking the first message cluster within the list of entries. This changes the relative position of the first message cluster.

Abstract: Systems and methods for throttling display of clustered electronic messages are disclosed. In some implementations, a method includes, at a computing device detecting occurrence of one or more cluster throttling trigger events for a first message cluster, of a first cluster type, in an email application. The method further includes updating a set of properties for the first message cluster in accordance with the one or more cluster throttling trigger events and comparing the updated set of properties for the first message cluster to one or more cluster display throttling rules associated with the first message cluster. The method further includes, in accordance with a determination that the set of properties for the first message cluster satisfies the one or more cluster display throttling rules, refreshing display of the first message cluster within a listing of electronic messages.

Abstract: A method for modifying access rights to electronically stored tiles linked in a draft electronic communication stored at a client device includes receiving, at a server from the client device, information relating to a plurality of recipients of the draft electronic communication, information relating to a sender of the draft electronic communication, and a first link, where the first link represents a first file. The method further includes determining, at the server, for the sender and for each recipient in the plurality of recipients, the access rights to the first file. The method further includes generating, at the server, a plurality of options for the sender to modify the access rights for the plurality of recipients, where the plurality of options is based on the access rights to the first file, and sending the plurality of options from the server to the client device.

Abstract: A system and method for providing a display of attachments for an e-mail message includes receiving an e-mail message with a plurality of attachments at a server, where one of the attachments is a file and a second of the attachments is a link to a file provided by a third party service. A request from the e-mail server is sent to a thumbnail generation service to generate a preview thumbnail for each attachment, where each preview thumbnail has a uniform appearance. The e-mail message and the preview thumbnails generated by the thumbnail generation service are sent to a client computer for display.

Abstract: Systems and methods for throttling display of clustered electronic messages are disclosed. In some implementations, a method includes, at a computing device detecting occurrence of one or more cluster throttling trigger events for a first message cluster, of a first cluster type, in an email application. The method further includes updating a set of properties for the first message cluster in accordance with the one or more cluster throttling trigger events and comparing the updated set of properties for the first message cluster to one or more cluster display throttling rules associated with the first message cluster. The method further includes, in accordance with a determination that the set of properties for the first message cluster satisfies the one or more cluster display throttling rules, refreshing display of the first message cluster within a listing of electronic messages.

Abstract: Systems and methods for managing electronic messages are disclosed. In some implementations, a method includes, at a computing device, causing an electronic message to be displayed to a user in an electronic message folder. Responsive to detecting that the user has read at least a portion of the electronic message, without user intervention, the electronic message is removed from the electronic message folder. In some implementations, the electronic message folder is a message inbox and the electronic message is removed from the message inbox to an archive or delete folder. In some implementations, the computing device includes one or more processors and memory storing one or more programs for execution by the one or more processors.

Abstract: A workstation support assembly comprises a support assembly, a post assembly rotationally supported by the support assembly and including a post member, a computer monitor support assembly operably coupled for rotation with a first end of the post member, and a keyboard support assembly operably coupled for rotation with a second end of the post member, wherein rotation of the keyboard support assembly forces rotation of the post member and the monitor support assembly, and wherein rotation of the monitor support assembly does not force the rotation of the keyboard support assembly.

Abstract: Chimeric proteins containing composite DNA-binding regions are disclosed together with DNA constructs encoding them, compositions containing them and applications in which they are useful.

Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene finction. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.

Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.

Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.

Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.

Abstract: Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transcription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.

Abstract: The present invention provides reagents such as cells, cell lines, and vectors, that can be used to identify mammalian genes whose expression products (RNA or protein) play a role in RNA interference (RNAi) and/or to identify chemical modulators of RNAi, or for other purposes. The invention further provides a variety of methods for identifying such genes or modulators. In particular, the invention provides a mammalian cell comprising a nucleic acid that encodes a selectable marker and one or more nucleic acid templates for transcription of an RNAi-inducing agent integrated into the genome of the cell, wherein the RNAi-inducing agent reduces expression of the marker and is not naturally found in the cell. Additional cells and cell lines comprising nucleic acids that encode one or more additional markers are also provided. According to certain of the inventive methods cells such as these are mutagenized, transfected or infected with a library of genetic suppressor elements, or contacted with a test compound.