Abstract: Methods and apparatus related to determining non-textual reply content for a reply to an electronic communication and providing the non-textual reply content for inclusion in the reply. Some of those implementations are directed to determining, based on an electronic communication sent to a user, one or more electronic documents that are responsive to the electronic communication, and providing one or more of those electronic documents for inclusion in a reply by the user to the electronic communication. For example, the electronic documents may be automatically attached to the reply and/or link(s) to the electronic documents automatically provided in the reply.

Abstract: A method for modifying access rights to electronically stored files linked in a draft electronic communication stored at a client device includes receiving, at a server from the client device, information relating to a plurality of recipients of the draft electronic communication, information relating to a sender of the draft electronic communication, and a first link, where the first link represents a first file. The method further includes determining, at the server, for the sender and for each recipient in the plurality of recipients, the access rights to the first file. The method further includes generating, at the server, a plurality of options for the sender to modify the access rights for the plurality of recipients, where the plurality of options is based on the access rights to the first file, and sending the plurality of options from the server to the client device.

Abstract: A method throttles display of electronic messages. The process displays a list of entries in an email application. The list of entries includes a first electronic message, a first message cluster, and a second message cluster. The process detects the occurrence of a cluster display trigger event for the first message cluster. The trigger event is one of: detection of passage of a predetermined amount of time since refreshing display of the first message cluster, an occurrence of a particular time of day, an occurrence of a predetermined date, or receipt by the first message cluster of a predefined number of new electronic messages since previously refreshing the display of the list. In response to the detected trigger event, the process refreshes the display of the list of entries, including re-ranking the first message cluster within the list of entries. This changes the relative position of the first message cluster.

Abstract: Methods and apparatus related to determining non-textual reply content for a reply to an electronic communication and providing the non-textual reply content for inclusion in the reply. Some of those implementations are directed to determining, based on an electronic communication sent to a user, one or more electronic documents that are responsive to the electronic communication, and providing one or more of those electronic documents for inclusion in a reply by the user to the electronic communication. For example, the electronic documents may be automatically attached to the reply and/or link(s) to the electronic documents automatically provided in the reply.

Abstract: The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a stabilizing triple helical structure. Related methods for expressing RNA in vivo and in vitro are also disclosed.

Abstract: The present invention relates to in vivo methods for modeling tumor formation and/or tumor evolution comprising the use of eukaryotic cells in which one or more genetic target locus has been altered by the CRISPR/Cas system, and which cells are transplanted in non-human eukaryote as a model system for tumor formation and tumor evolution. In particular in vivo genetic screening methods for identifying genes involved in tumorigenesis and metastasis are disclosed. The invention further relates to kits and components for practicing the methods, as well as materials obtainable by the methods, in particular tumor and metastasis samples and cells or cell lines derived therefrom. The invention also relates to diagnostic and therapeutic methods derived from the information obtained in the modeling methods.

Abstract: The invention involves inducing 3-50 or more mutations (e.g., any whole number between 3 and 50 of mutations, with it noted that in some embodiments there can be up to 16 different RNA(s), e.g., sgRNAs each having its own a promoter, in a vector, such as AAV, and that when each sgRNA does not have its own promoter, there can be twice to thrice that amount of different RNA(s), e.g., sgRNAs, e.g., 32 or even 48 different guides delivered by one vector) in transgenic Cas9 eukaryotes to model genetic disease, e.g. cancer. The invention comprehends testing putative treatments with such models, e.g., testing putative chemical compounds that may be pharmaceutically relevant for treatment or gene therapy that may be relevant for treatment, or combinations thereof. The invention allows for the study of genetic diseases and putative treatments to better understand and alleviate a genetic disease or a condition, e.g., cancer.

Abstract: The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a 3? terminal stabilizing triple helical structure. Related methods for expressing said RNAs in vivo and in vitro are also disclosed.

Abstract: Methods and apparatus related to determining reply content for a reply to an electronic communication and providing the reply content for inclusion in the reply. Some of those implementations are directed to determining, based on an electronic communication that includes an event and is sent to a user, reply content that is tailored to the electronic communication and tailored to schedule data of the user that is temporally related to the event, and providing the reply content for inclusion in a reply by the user to the electronic communication. For example, the reply content may be automatically included in the reply and/or suggested for inclusion in the reply.

Abstract: Methods and apparatus related to determining non-textual reply content for a reply to an electronic communication and providing the non-textual reply content for inclusion in the reply. Some of those implementations are directed to determining, based on an electronic communication sent to a user, one or more electronic documents that are responsive to the electronic communication, and providing one or more of those electronic documents for inclusion in a reply by the user to the electronic communication. For example, the electronic documents may be automatically attached to the reply and/or link(s) to the electronic documents automatically provided in the reply.

Abstract: The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-ADP-ribose polymerase (PARP) inhibitors, one or more PARP activators, one or more poly-ADP-ribose glycosylase (PARG) activators, and/or one or more poly-ADP-ribose glycohydrolase ARH3 activators. The invention also provides corresponding methods of decreasing stress granule formation and/or proliferation in a cell or a population of cells. The invention further provides methods of increasing the number of stress granules and proliferation in a cell or a population of cells by administering one or more PARP activators, one or more PARP inhibitors, one or more PARG inhibitors, and/or one or more ARH3 inhibitors.

Abstract: A method for modifying access rights to electronically stored files linked in a draft electronic communication stored at a client device includes receiving, at a server from the client device, information relating to a plurality of recipients of the draft electronic communication, information relating to a sender of the draft electronic communication, and a first link, where the first link represents a first file. The method further includes determining, at the server, for the sender and for each recipient in the plurality of recipients, the access rights to the first file. The method further includes generating, at the server, a plurality of options for the sender to modify the access rights for the plurality of recipients, where the plurality of options is based on the access rights to the first file, and sending the plurality of options from the server to the client device.

Abstract: Systems and methods for managing electronic messages are disclosed. In some implementations, a method includes, at a computing device, causing an electronic message to be displayed to a user in an electronic message folder. Responsive to detecting that the user has read at least a portion of the electronic message, without user intervention, the electronic message is removed from the electronic message folder. In some implementations, the electronic message folder is a message inbox and the electronic message is removed from the message inbox to an archive or delete folder. In some implementations, the computing device includes one or more processors and memory storing one or more programs for execution by the one or more processors.

Abstract: The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-ADP-ribose polymerase (PARP) inhibitors, one or more PARP activators, one or more poly-ADP-ribose glycosylase (PARG) activators, and/or one or more poly-ADP-ribose glycohydrolase ARH3 activators. The invention also provides corresponding methods of decreasing stress granule formation and/or proliferation in a cell or a population of cells. The invention further provides methods of increasing the number of stress granules and proliferation in a cell or a population of cells by administering one or more PARP activators, one or more PARP inhibitors, one or more PARG inhibitors, and/or one or more ARH3 inhibitors.

Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAI. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.

Abstract: A method throttles display of electronic messages. The process displays a list of entries in an email application. The list of entries includes a first electronic message, a first message cluster, and a second message cluster. The process detects the occurrence of a cluster display trigger event for the first message cluster. The trigger event is one of: detection of passage of a predetermined amount of time since refreshing display of the first message cluster, an occurrence of a particular time of day, an occurrence of a predetermined date, or receipt by the first message cluster of a predefined number of new electronic messages since previously refreshing the display of the list. In response to the detected trigger event, the process refreshes the display of the list of entries, including re-ranking the first message cluster within the list of entries. This changes the relative position of the first message cluster.

Abstract: The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23 nt fragments are purified and added back to Drosophila extracts, they mediate RNA interference in the absence of long dsRNA. Thus, these 21-23 nt fragments are the sequence-specific mediators of RNA degradation. A molecular signal, which may be their specific length, must be present in these 21-23 nt fragments to recruit cellular factors involved in RNAi. This present invention encompasses these 21-23 nt fragments and their use for specifically inactivating gene function. The use of these fragments (or chemically synthesized oligonucleotides of the same or similar nature) enables the targeting of specific mRNAs for degradation in mammalian cells, where the use of long dsRNAs to elicit RNAi is usually not practical, presumably because of the deleterious effects of the interferon response.

Abstract: The invention relates in aspects to hybrid RNAs lacking a poly-A tail and nucleic acid vectors for expressing the RNA. The hybrid RNAs in some instances have a 3? terminal stabilizing triple helical structure. Related methods for expressing said RNAs in vivo and in vitro are also disclosed.

Abstract: Systems and methods for throttling display of clustered electronic messages are disclosed. In some implementations, a method includes, at a computing device detecting occurrence of one or more cluster throttling trigger events for a first message cluster, of a first cluster type, in an email application. The method further includes updating a set of properties for the first message cluster in accordance with the one or more cluster throttling trigger events and comparing the updated set of properties for the first message cluster to one or more cluster display throttling rules associated with the first message cluster. The method further includes, in accordance with a determination that the set of properties for the first message cluster satisfies the one or more cluster display throttling rules, refreshing display of the first message cluster within a listing of electronic messages.

Abstract: A system and method for providing a display of attachments for an e-mail message includes receiving an e-mail message with a plurality of attachments at a server, where one of the attachments is a file and a second of the attachments is a link to a file provided by a third party service. A request from the e-mail server is sent to a thumbnail generation service to generate a preview thumbnail for each attachment, where each preview thumbnail has a uniform appearance. The e-mail message and the preview thumbnails generated by the thumbnail generation service are sent to a client computer for display.