Abstract: The present invention is directed to methods for determining whether a selected cancer is susceptible to an activity of an arylhydrocarbon receptor agonist, such as aminoflavone, via screening the cancer for expression of isoform 3 of aryl hydrocarbon nuclear translocator.

Abstract: Disclosed are methods of treating breast cancer by administering to a mammal aminoflavone, and optionally one or more additional anti-cancer agents. According to example embodiments, the methods include methods of treating cancers resistant to endocrine therapy.

Abstract: To increase the wear resistance of the nose of a chain saw guide bar, a U-shaped strip of wear-resistant alloy is welded to the edge surface of each side rail of the guide bar at the nose. Each strip has a greater width at the crest of the strip than at the ends thereof. The strips are formed by making identical curved cuts through a plate formed of the alloy, whereby each cut forms a wave-shaped element comprising at least two U-shaped strips that are joined end-to-end. The individual strips of the element are severed from one another before being welded to the respective side rails. The strips could be formed of cobalt-chrome-tungsten alloy, and thermally age-hardened, prior to being welded onto the side rail.