Abstract: A device (100) for sensing sweat on skin (12) includes a first analyte-specific sensor (120, 122) for sensing a first analyte in sweat; a sweat stimulating component (140); a waste collector (142, 144, 146, 148) beneath the sweat stimulating component (140); and an additional component being one or more of a sweat collector (130, 132, 134) or an additional analyte-specific sensor (124) for sensing an additional analyte in sweat that is different from the first analyte, the additional component being adjacent to and fluidically isolated from the waste collector (142, 144, 146, 148). A device (200) for sensing sweat on skin (12) includes a first portion comprising a first analyte-specific sensor (220) for sensing a first analyte in stimulated sweat and a sweat stimulating component (240); and a second portion comprising a second analyte-specific sensor (225, 226) for sensing a second analyte in natural sweat.

Abstract: A method for stimulating and sensing sweat includes dosing a sweat stimulant to skin effective to generate sweat at a generation rate of at least 0.1 nL/min/gland for a duration of six hours or more per dose of the sweat stimulant, and sensing generated sweat using a device placed on the skin comprising at least one sensor specific to an analyte in sweat. The dosing comprises at least one of: applying a charge density of less than 320 mC/cm2/day or applying a one-time dose of the sweat stimulant.