Abstract: The present invention relates to biomarkers and methods of using the same. Specifically, the present invention relates to biomarkers for nonalcoholic fatty liver disease and related disease phenotypes and methods of using the same.

Abstract: The present invention relates to compositions and methods for the treatment of NAFLD. Specifically, the present invention relates to compositions comprising one or more BCDKH agonists and methods of using the same for the treatment of NAFLD.

Abstract: An e-mail sender is provided with an option to send a notification to the prospective recipient(s) of an e-mail indicating to the recipient that an e-mail has been sent to his or her attention or to a business or other entities attention. The notification can be advantageously sent by a different communications route, such as by mail, courier, telephone call, facsimile, social network, or other method. Back up notifications can also be sent on an automated basis. The notification can be sent automatically and/or sent a period of time after the e-mail is sent if an acknowledgment or reply is not received.

Abstract: An e-mail sender is provided with an option to send a notification to the prospective recipient(s) of an e-mail indicating to the recipient that an e-mail has been sent to his or her attention or to a business or other entities attention. The notification can be advantageously sent by a different communications route, such as by mail, courier, telephone call, facsimile, social network, or other method. Back up notifications can also be sent on an automated basis. The notification can be sent automatically and/or sent a period of time after the e-mail is sent if an acknowledgment or reply is not received.

Abstract: The disclosed system, device and method for providing a substantially leak-proof tube/manifold seal generally includes a partially deformable polymeric ferrule (100), a retaining ring (110) and a nut (130) configured to drive and deform the ferrule (100) against a receiving manifold surface (144). Disclosed features and specifications may be variously controlled, adapted or otherwise optionally modified to improve tube seal seating and/or engagement. Exemplary embodiments of the present invention generally allow for the use of tube coupling hardware (e.g., ferrules) that would otherwise need to be reworked, replaced or discarded.

Abstract: A product purchase decision making device for assisting consumers in making purchase decisions. Data identifying the product is inputted into the handheld device, either by the consumer directly or by scanning the products' bar code label. The device accesses a global telecommunication network to retrieve information concerning that product from an information database, such as the manufacturers' website or a consumer reporting agency. A decision is automatically displayed to the consumer by a series of decision buttons, indicating a “yes” or “no” decision, or a “caution” decision advising the consumer to research additional information. The additional information may be automatically displayed on the device's display screen. The device comprises a handheld computer, personal data assistant or a cellular telephone.

Abstract: There is provided a bicycle frame comprising a first tube; a second tube extending transversely from an upper region of the first tube; a third tube extending transversely and downwardly from a lower region of the first tube, and towards the same direction as the second tube; and a two-part tube joining the respective ends of the second and third tubes, the two-part tube having a straight upper part and a curved lower part, the straight upper part being substantially vertical and the curved lower part being curved longitudinally towards the first tube such as to conform to the curvature of a bicycle wheel.

Abstract: A system, process and computer readable medium for providing in-store printing of rainchecks for purchasing incentives associated with items subject to rainchecks, including an incentive processor for storing a plurality of purchasing incentives corresponding to a plurality of item identifiers for items subject to rainchecks; at least one incentive printer; a incentive processor bus coupling the incentive processor to the at least one incentive printer; a point-of-sale (POS) controller; at least one cash register; and a POS bus coupling the POS controller, the at least one cash register, and the incentive processor. A respective cash register of the at least one cash register is configured to receive data defining an item identifier for an item that is subject to a raincheck. One of the POS controller and the respective cash register is configured to transmit the data defining the item identifier for the item that is subject to the raincheck over the POS bus to the incentive processor.