Abstract: The invention relates to a method for spatially manipulating a microscopic object (20,23,33), said method comprising the steps of providing a cantilever (12) having a tip with an opening (19) and a microchannel (15) extending through the cantilever (12) in its longitudinal direction, said microchannel (15) being fluidly connected to the opening (19) at the tip of the cantilever; providing suspension means for holding the cantilever (12) and spatially moving the cantilever along a predetermined spatial path; providing pressurizing means for applying a predetermined pressure to the microchannel (15) within the cantilever; moving the cantilever (12) with its tip to the microscopic object (20,23,33) to be spatially manipulated, such that the opening (19) of the tip is adjacent to the microscopic object (20,23,33); picking up, with said cantilever (12), a part of the microscopic object (20,23,33) or the microscopic object (20,23,33) as a whole by reducing the pressure within the microchannel (15) relative to the p