Patents by Inventor Phoebe E. Fielding

Phoebe E. Fielding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulation of the cell cycle by sterols
    Patent number: 6261760
    Abstract: This invention provides a novel intracellular recycling free cholesterol pathway whose activity is required for cell division. The pathway provides the cholesterol needed for cell division prior to separation of daughter cells (mitosis). The new pathway offers several targets from pharmaceutical intervention, either via small molecules (such as sterol analogs) or by molecular engineering (preventing the cell from accumulating cholesterol by promoting free cholesterol efflux by transfection of caveolin cDNA).
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: July 17, 2001
    Assignee: The Regents of The University of California
    Inventors: Christopher J. Fielding, Phoebe E. Fielding
  • Inhibition of cellular uptake of cholesterol
    Patent number: 5922554
    Abstract: This invention provides for methods of reducing cholesterol uptake by a cell. The invention is premised in part on the discovery of a new mechanisms by which free cholesterol (FC) is internalized into a cell from low-density lipoproteins. Inhibition of this mechanism reduces the internalization of free cholesterol into cholesterol transport vesicles thereby reducing free cholesterol content of the cell at physiological concentrations of LDL and HDL.
    Type: Grant
    Filed: October 29, 1996
    Date of Patent: July 13, 1999
    Assignee: The Regents of the University of California
    Inventors: Christopher J. Fielding, Phoebe E. Fielding