Abstract: Provided herein are antibodies that specifically bind to CD25. Also provided herein are methods of making the antibodies described, and methods of use thereof. For example, the CD25 antibodies may be used therapeutically to treat cancer or autoimmune diseases.

Abstract: Provided herein engineered polypeptides that comprise a combination of spatially-associated topological constraints, wherein at least one constraint is derived from a CD25 reference target, and methods of selecting said engineered polypeptides. Further provided are methods of using the engineered polypeptides, including as positive and/or negative selection molecules in methods of screening a library of binding molecules such as antibodies. Further provided herein are CD25 antibodies selected using these engineered polypeptides.

Abstract: Provided is a dynamic vibration attenuation system 10 for a granular material silo 8. The system 10 comprises a sensor arrangement 12, a processor 16, and a damping arrangement 24. The sensor arrangement 12 is configured for operatively sensing, over a period comprising a plurality of instances of time, a displacement of the silo 8, a weight of granular material in the silo 8, and a flow rate of granular material discharged from the silo 8. The processor 16 is arranged in signal communication with the sensor arrangement 12 and is configured to calculate, at each instance of time, a resultant dynamic force from the sensed displacement, weight and flow rate. System 10 further includes damping arrangement 24 which is operatively responsive to the processor 16 and is configured to dynamically dampen the resultant dynamic force in order to maintain vibration amplitudes in the silo structure 9 below a user-selectable threshold.

Abstract: Provided herein are humanized CD25 antibodies, methods of making, and use thereof. In some embodiments, the CD25 antibodies are useful for the treatment of cancer or autoimmune diseases.

Abstract: Provided is a dynamic vibration attenuation system 10 for a granular material silo 8. The system 10 comprises a sensor arrangement 12, a processor 16, and a damping arrangement 24. The sensor arrangement 12 is configured for operatively sensing, over a period comprising a plurality of instances of time, a displacement of the silo 8, a weight of granular material in the silo 8, and a flow rate of granular material discharged from the silo 8. The processor 16 is arranged in signal communication with the sensor arrangement 12 and is configured to calculate, at each instance of time, a resultant dynamic force from the sensed displacement, weight and flow rate. System 10 further includes damping arrangement 24 which is operatively responsive to the processor 16 and is configured to dynamically dampen the resultant dynamic force in order to maintain vibration amplitudes in the silo structure 9 below a user-selectable threshold.