Abstract: Disclosed herein are novel aryl-substituted N-alkyl indoles useful as pharmacologically active agents, the novel compounds having the structure of formula wherein m, p, q, L1 through L3, R1 through R5, and Ar are defined herein. Also provided are pharmaceutical formulations comprising at least one aryl-substituted N-alkyl indole of the invention, at least one pharmaceutically acceptable excipient, and, optionally, an additional beneficial agent, along with methods for treating a subject affected by a condition, disorder, or disease responsive to administration of the aryl-substituted N-alkyl indole. Exemplary methods of use include treatment of pain, treatment of inflammation, treatment of endometriosis, and a method for inducing weight loss.

Abstract: Disclosed herein are novel cannabinol (CBN) analogs, each exhibiting a difference in the level and/or type of interaction with the CB1 receptor as compared with the CB2 receptor, and, as such, provide for a significant reduction in psychoactive effects relative to CBN per se. Also provided are pharmaceutical formulations comprising at least one CBN analog of the invention, at least one optional pharmaceutically acceptable excipient, and, also optionally, an additional beneficial agent, along with methods for treating a subject affected by a condition, disorder, or disease responsive to administration of the CBN analog. Exemplary methods of use include treatment of pain, treatment of endometriosis, treatment of inflammation, and a method for inducing weight loss.

Abstract: Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((?)-trans-?9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.

Abstract: Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((?)-trans-?9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.