Patents by Inventor Pia D. Vogel
Pia D. Vogel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220175777Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: January 26, 2022Publication date: June 9, 2022Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 11234978Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: September 26, 2019Date of Patent: February 1, 2022Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 11013739Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: November 6, 2019Date of Patent: May 25, 2021Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit, Amila K. Nanyakkara, Alexander R. Lippert, Maha Ali Aljowni
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Publication number: 20210134398Abstract: A method for identifying a potentially useful molecular combination includes applying a selection procedure to a compound to identify a first set of candidate molecules, the procedure including providing a chemical synthesis scheme, a virtual scaffold molecule of the compound, and a virtual reactant fragment to react with the scaffold molecule according to the scheme; preparing the reactant fragment and the scaffold molecule for analyzing combinations of them; designating a remaining scaffold subset and a remaining fragment subset if a product molecule can be formed from them; rotating the fragment subset about an axis connecting the scaffold subset and the fragment subset incrementally through 360 degrees; and identifying potentially useful combinations of the reactant fragment and the scaffold molecule; identifying a set of combinatorial fragments from the first set of candidates; and applying the selection procedure to the set of combinatorial fragments to identify a second set of candidate molecules.Type: ApplicationFiled: November 6, 2020Publication date: May 6, 2021Inventors: John G. Wise, Pia D. Vogel
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Patent number: 10898485Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: December 16, 2019Date of Patent: January 26, 2021Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20200138816Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: December 16, 2019Publication date: May 7, 2020Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20200069687Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: November 6, 2019Publication date: March 5, 2020Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit, Amila K. Nanyakkara, Alexander R. Lippert, Maha Ali Aljowni
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Patent number: 10548893Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: November 29, 2018Date of Patent: February 4, 2020Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 10543210Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: March 27, 2019Date of Patent: January 28, 2020Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Publication number: 20200016157Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: September 26, 2019Publication date: January 16, 2020Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20190216811Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: March 27, 2019Publication date: July 18, 2019Inventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Patent number: 10292982Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: March 5, 2018Date of Patent: May 21, 2019Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Publication number: 20190091223Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: November 29, 2018Publication date: March 28, 2019Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 10172855Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: January 13, 2017Date of Patent: January 8, 2019Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20180185366Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: March 5, 2018Publication date: July 5, 2018Inventors: John G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Publication number: 20170128447Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: January 13, 2017Publication date: May 11, 2017Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Patent number: 9561227Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: GrantFiled: January 15, 2015Date of Patent: February 7, 2017Assignee: Southern Methodist UniversityInventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
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Publication number: 20150196560Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.Type: ApplicationFiled: January 15, 2015Publication date: July 16, 2015Inventors: John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit