Patents by Inventor Pier Giovanni Baraldi

Pier Giovanni Baraldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N.sup.6 -substituted-adenosine-5'-uronamides as adenosine receptor modulator
    Patent number: 6048865
    Abstract: A series of adenosine-5'-uronamide derivatives bearing N.sup.6 -arylurea, alkarylurea, heteroarylurea, arylcarbonyl, alkarylcarbonyl or heteroarylcarbonyl groups which have affinity and, in some cases, selectivity for the adenosine A.sub.1 or A.sub.3 receptors are disclosed. These compounds can be used in a pharmaceutical composition to treat disorders caused by excessive activation of the A.sub.1 or A.sub.3 receptors, or can be used in a diagnostic application to determine the relative binding of other compounds to the A.sub.1 or A.sub.3 receptors.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: April 11, 2000
    Assignee: Medco Research, Inc.
    Inventor: Pier Giovanni Baraldi
  • Thiophenes useful for modulating the adenosine receptor
    Patent number: 5939432
    Abstract: The present invention relates to compounds of formulas (IA), (IB), and (IC): ##STR1## the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection against hypoxia and ischemia induced injury and treatment of adenosine-sensitive cardiac arrhythmias.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: August 17, 1999
    Assignee: Medco Research, Inc.
    Inventor: Pier Giovanni Baraldi
  • 1,2,4-triazolo?1,5-c! pyrimidine heterocyclic analogues having antagonistic activity on adenosine A.sub.2a receptor
    Patent number: 5935964
    Abstract: Disclosed are adenosine A.sub.2a receptor antagonists of the formula ##STR1## wherein A is pyrazole, imidazole or triazole ring; R is ##STR2## R.sub.1 and R.sub.2 are independently H, OH, halogen, alkoxy, alkyl, nitro, amino, CN, haloalkyl, haloalkoxy, carboxy or carboxamido; or the OH group together with one of R.sub.1 or R.sub.2, or R.sub.1 and R.sub.2 together, form a methylenedioxy group;and n is 0-4;said compounds are useful in the treatment of cardiovascular, central nervous system, and respiratory diseases.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: August 10, 1999
    Assignee: Schering Corporation
    Inventors: Pier Giovanni Baraldi, Barbara Cacciari, Monica Valeria Angela Viziano, Silvio Dionisotti, Ennio Ongini
  • Distamycin A analogues as antitumour or antiviral agents
    Patent number: 5753629
    Abstract: The present invention relates to compounds of formula (I) ##STR1## The compounds of the invention are useful as antitumor or antiviral agents.
    Type: Grant
    Filed: March 18, 1996
    Date of Patent: May 19, 1998
    Assignee: Pharmacia S.p.A.
    Inventors: Italo Beria, Enrico Pesenti, Laura Capolongo, Nicola Mongelli, Pier Giovanni Baraldi