Patents by Inventor Pierce OGDEN

Pierce OGDEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TARGETED DELIVERY OF THERAPEUTICS
    Publication number: 20260158147
    Abstract: Compositions, methods and systems for targeted delivery using one or more shuttles operably linked to one or more cargos (e.g., cargo polypeptides, e.g., cargo oligonucleotides) and subsequent quantification of an abundance of one or more cargos (e.g., proteins) in a mixture (e.g., a complex mixture (e.g., in vivo)) or in a specific cell, tissue, or organ of interest (e.g., in vivo) using barcodes (e.g., peptide barcodes), binders (e.g., polypeptide binders), and binding agents (e.g., phage) are provided herein.
    Type: Application
    Filed: May 12, 2025
    Publication date: June 11, 2026
    Inventors: Pierce Ogden, Kathleen Nudel, Erik Swanson, Salvatore Alioto, Alvaro Garcia, Karen Duffy, Alexander Reis, Glenn Gordon Hauk, Naveen Khinduka Mehta, Marshall A. Case
  • Engineered viral capsid polypeptides and uses thereof
    Patent number: 12617821
    Abstract: The technology described herein provides variant adeno-associated viral capsid polypeptides and viruses comprising the same. Such variant viral capsid polypeptides bear a mutation relative to SEQ ID NO: 2 (WT AAV2) in a region corresponding to amino acids 561-588, wherein the region corresponding to amino acids 561-588 comprises a sequence selected from SEQ ID NO: 4-41,337. Further provided herein are methods for delivering a viral payload using viruses comprising variant capsid polypeptides described herein.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: May 5, 2026
    Inventors: Eric Kelsic, Sam Sinai, Pierce Ogden, George M. Church
  • Viral vectors exhibiting improved gene delivery properties
    Patent number: 12338267
    Abstract: The technology described herein provides viral capsid polypeptides bearing mutations that alters tissue tropism of a virus comprising the viral capsid polypeptide. In various embodiments, tissue tropisim to the heart, kidney, liver, lung, spleen, or blood is altered.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: June 24, 2025
    Inventors: George M. Church, Eric Kelsic, Pierce Ogden, Sam Sinai
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20250019688
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g., proteins) in a mixture (e.g., a complex mixture (e.g., in vivo)) using barcodes (e.g., peptide barcodes), binders (e.g., polypeptide binders), and binding agents (e.g., phage) are provided herein.
    Type: Application
    Filed: November 2, 2022
    Publication date: January 16, 2025
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • METHODS AND COMPOSITIONS FOR HIGH-THROUGHPUT PROTEIN DELIVERY, SCREENING, AND DETECTION
    Publication number: 20240401025
    Abstract: Methods and systems for delivery using one or more delivery particles (e.g., virions (e.g., AAV), lipid-based delivery particles, etc.) of one or more cargos (e.g., cargo polypeptides) and subsequent quantification of an abundance of one or more cargos (e.g., proteins) in a mixture (e.g., a complex mixture (e.g., in vivo)) using barcodes (e.g., peptide barcodes), binders (e.g., polypeptide binders), and binding agents (e.g., phage) are provided herein.
    Type: Application
    Filed: May 2, 2024
    Publication date: December 5, 2024
    Inventors: Pierce Ogden, Alvaro Garcia, Salvatore Alioto
  • Methods and compositions for protein detection
    Patent number: 12037706
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Grant
    Filed: April 11, 2022
    Date of Patent: July 16, 2024
    Assignee: Manifold Biotechnologies, Inc.
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • Methods and compositions for protein detection
    Patent number: 11976384
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: May 7, 2024
    Assignee: Manifold Biotechnologies, Inc.
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20240117526
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Application
    Filed: August 21, 2023
    Publication date: April 11, 2024
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20230134536
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Application
    Filed: November 3, 2021
    Publication date: May 4, 2023
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • METHODS AND COMPOSITIONS FOR PROTEIN DETECTION
    Publication number: 20230134754
    Abstract: Methods and systems for quantification of an abundance of one or more payloads (e.g. proteins) in a mixture (e.g. a complex mixture (e.g. in vivo)) using barcodes (e.g. peptide barcodes), binders (e.g. polypeptide binders), and binding agents (e.g. phage) are provided herein.
    Type: Application
    Filed: April 11, 2022
    Publication date: May 4, 2023
    Inventors: Pierce Ogden, Gleb Kuznetsov, Shane Lofgren, Kathleen Nudel, Hoong Chuin Lim, Karen Duffy, Jeffrey Chang
  • VIRAL CAPSID POLYPEPTIDES
    Publication number: 20230002451
    Abstract: The technology described herein provides variant adeno-associated viral capsid polypeptides and viruses comprising the same. Further provided herein are methods for delivering a viral payload using viruses comprising variant capsid polypeptides described herein.
    Type: Application
    Filed: November 6, 2020
    Publication date: January 5, 2023
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eric KELSIC, Sam SINAI, Pierce OGDEN, George M. CHURCH
  • VIRAL VECTORS EXHIBITING IMPROVED GENE DELIVERY PROPERTIES
    Publication number: 20210230229
    Abstract: The technology described herein provides viral capsid polypeptides bearing mutations that alters tissue tropism of a virus comprising the viral capsid polypeptide. In various embodiments, tissue tropisim to the heart, kidney, liver, lung, spleen, or blood is altered.
    Type: Application
    Filed: May 8, 2019
    Publication date: July 29, 2021
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: George M. CHURCH, Eric KELSIC, Pierce OGDEN, Sam SINAI