Patents by Inventor Piergiuseppe Orezzi

Piergiuseppe Orezzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,1-dioxo-cephem-4-carbothiolic acid derivatives
    Patent number: 5356888
    Abstract: There are provided compounds I ##STR1## wherein A is a hydrogen atom or an organic group,R.sub.1 is hydrogen or halogen atom or an organic group,R.sub.2 is hydrogen or halogen atom, C.sub.1 -C.sub.4 alkyl or acyloxy group,R.sub.3 is hydrogen atom, C.sub.1 -C.sub.4 alkyl or alkoxy, benzyl group or a methylene andR.sub.4 is chloro, fluoro, hydrogen atom or an organic group.The compounds I are elastase inhibitors. A process for their preparation is also provided, as are pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 22, 1991
    Date of Patent: October 18, 1994
    Assignee: Farmitalia Carlo Erba
    Inventors: Marco Alpegiani, Pierluigi Bissolino, Ettore Perrone, Francesco Di Matteo, Piergiuseppe Orezzi, Giuseppe Cassinelli
  • .beta.-lactam derivatives of the cephem sulphone type
    Patent number: 5348952
    Abstract: Cephalosporins of the formula (I): ##STR1## wherein m is one or two; n is zero, one or two; A and B are organic residues; and R.sub.1 and R.sub.2 are halogen or hydrogen atoms or organic groups are endowed with elastase inhibitory activity. Two processes for their preparation starting from the corresponding 4-acyl cephem are also provided.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: September 20, 1994
    Assignee: Farmitalia Carlo Erba S.R.L.
    Inventors: Pierluigi Bissolino, Marco Alpegiani, Ettore Perrone, Piergiuseppe Orezzi, Giuseppe Cassinelli, Giovanni Franceschi
  • 6-substituted penem esters as anti-inflammatory and anti-degenerative agents
    Patent number: 5089489
    Abstract: 6-substituted penem esters of formula (I): ##STR1## wherein R.sub.1 is halogen or a C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, phenyl, phenoxy, benzyl or sulphonyloxy group; R.sub.2 is a C.sub.1 -C.sub.4 alkyl, benzyl diphenylmethyl ##STR2## group where A is C.sub.1 -C.sub.4 alkyl, benzyl, p-nitrobenzyl or p-methoxybenzyl; and R.sub.3 is an organic radical, are elastase inhibitors and thereby useful antiinflammatory and antidegenerative agents.
    Type: Grant
    Filed: April 5, 1990
    Date of Patent: February 18, 1992
    Assignee: Farmitalia Carlo Erba S.r.l.
    Inventors: Marco Alpegiani, Ettore Perrone, Piergiuseppe Orezzi, Paolo Carminati, Giuseppe Cassinelli
  • Beta-lactam derivatives of the 4-acylcephem sulphone and 3-acylpenam sulphone-type
    Patent number: 5077286
    Abstract: Compounds of formulae Ia and Ib ##STR1## wherein A is hydrogen atom or an organic residue, R.sup.1 is halogen atom, or an organic group, R.sup.2 is hydrogen or halogen atom, C.sub.1 -C.sub.4 alkyl or alkoxy group, R.sup.3 is hydrogen atom, C.sub.1 -C.sub.4 alkyl or alkoxy group, benzyl or a methylene group and R.sub.4 is an organic residue are disclosed. Compounds (Ia) and (Ib) are endowed with elastase inhibitory activity. A two-step process for their preparation starting from the corresponding 4-carboxy cephem or 3-carboxy penam is also provided.
    Type: Grant
    Filed: April 10, 1989
    Date of Patent: December 31, 1991
    Assignee: Farmitalia Carlo Erba S.r.l.
    Inventors: Pierluigi Bissolino, Marco Alpegiani, Ettore Perrone, Piergiuseppe Orezzi, Giuseppe Cassinelli, Giovanni Franceschi
  • 6-substituted penem esters as anti-inflammatory and anti-degenerative agents
    Patent number: 4954493
    Abstract: 6-substituted penem esters of formula (I): ##STR1## wherein R.sub.1 is halogen or a C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, phenyl, phenoxy, benzyl, or sulphonyloxy group; R.sub.2 is a C.sub.1 -C.sub.4 alkyl, benzyl diphenylmethyl ##STR2## group where A is C.sub.1 -C.sub.4 is C.sub.1 -C.sub.4 alkyl, benzyl, p-nitrobenzyl or p-methoxybenzyl; and R.sub.3 is an organic radical, are elastase inhibitors and thereby useful antiinflammatory and antidegenerative agents.
    Type: Grant
    Filed: June 14, 1988
    Date of Patent: September 4, 1990
    Assignee: Farmitalia Carlo Erba S.r.l.
    Inventors: Marco Alpegiani, Ettore Perrone, Piergiuseppe Orezzi, Paolo Carminati, Giuseppe Cassinelli
  • Process of preparation of antibiotic F.I. 1762 derivatives
    Patent number: 4012284
    Abstract: 1. A process for the preparation of a new antibiotic F.I. 1762, which comprises cultivating the Streptomyces 1762 under aerobic conditions in a liquid nutrient medium containing a carbon source, a nitrogen source and mineral salts, at a temperature between 25.degree. and 37.degree. C, over a period of time from 3 to 7 days, and extracting the formed antibiotic from the fermentation broth at a pH between 8 and 9 by means of a water-immiscible solvent, isolating and purifying the antibiotic F.I. 1762.
    Type: Grant
    Filed: October 6, 1964
    Date of Patent: March 15, 1977
    Assignee: Societa' Farmaceutici Italia, S.p.A.
    Inventors: Aurelio Di Marco, Graziana Canevazzi, Arpad Grein, Piergiuseppe Orezzi, Marcello Gaetani