Patents by Inventor Pierluigi Padovan

Pierluigi Padovan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic process for the preparation of Droxidopa
    Patent number: 11434197
    Abstract: The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: September 6, 2022
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Stefano Fogal, Paolo Stabile, Pierluigi Padovan, Matteo De Poli, Angelo Restelli
  • Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272
    Patent number: 11370800
    Abstract: Object of the present invention is an improved process for the preparation of cyclopropyldiketopiperazines and thereof key intermediates.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: June 28, 2022
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Pierluigi Padovan, Kexia Lou
  • Highly stable crystalline Eltrombopag monoethanolamine salt form D1
    Patent number: 11267791
    Abstract: Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: March 8, 2022
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas Tesson, Jordi De Mier Vinue, Paolo Stabile, Pierluigi Padovan, Matteo De Poli, Angelo Restelli
  • Crystalline Eltrombopag monoethanolamine salt form D
    Patent number: 11214547
    Abstract: Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: January 4, 2022
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas Tesson, Jordi De Mier Vinue, Paolo Stabile, Pierluigi Padovan, Matteo De Poli, Angelo Restelli
  • Efficient process for the preparation of sitagliptin
    Patent number: 11174266
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: November 16, 2021
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Terry Shi, Sam Lou, Ottorino De Lucchi, Pierluigi Padovan
  • HIGHLY STABLE CRYSTALLINE ELTROMBOPAG MONOETHANOLAMINE SALT FORM D1
    Publication number: 20210284611
    Abstract: Object of the present invention is a highly stable crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D1, having the highest thermodynamically stability with excellent non-hygroscopicity, and particularly well suitable for pharmaceutical purposes, with related process.
    Type: Application
    Filed: July 25, 2019
    Publication date: September 16, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas TESSON, Jordi DE MIER VINUE, Paolo STABILE, Pierluigi PADOVAN, Matteo DE POLI, Angelo RESTELLI
  • CRYSTALLINE ELTROMBOPAG MONOETHANOLAMINE SALT FORM D
    Publication number: 20210198211
    Abstract: Object of the present invention is a better crystalline form of Eltrombopag (ETP) monoethanolamine salt, named Form D, stable, suitable for pharmaceutical purposes, and with the highest solubility in water and excellent non-hygroscopicity, then the related process and intermediates thereof.
    Type: Application
    Filed: July 25, 2019
    Publication date: July 1, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Nicolas TESSON, Jordi DE MIER VINUE, Paolo STABILE, Pierluigi PADOVAN, Matteo DE POLI, Angelo RESTELLI
  • ENZYMATIC PROCESS FOR THE PREPARATION OF DROXIDOPA
    Publication number: 20210163401
    Abstract: The present invention relates to a process for the preparation of Droxidopa by means of an improved enzymatic reduction of a compound of formula (II): (II), wherein R1, R2 is independent hydrogen, acetyl, R3 is hydrogen, a C1-C4 linear or branched alkyl group and R4 is hydrogen or an amine protecting group.
    Type: Application
    Filed: June 7, 2019
    Publication date: June 3, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Stefano FOGAL, Paolo STABILE, Pierluigi PADOVAN, Matteo DE POLI, Angelo RESTELLI
  • NEW EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN
    Publication number: 20210061808
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Application
    Filed: January 11, 2019
    Publication date: March 4, 2021
    Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Terry SHI, Sam LOU, Ottorino DE LUCCHI, Pierluigi PADOVAN
  • Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
    Patent number: 10913747
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: February 9, 2021
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Ottorino De Lucchi, Pierluigi Padovan, Elena Brasola
  • PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272
    Publication number: 20200377521
    Abstract: Object of the present invention is an improved process for the preparation of cyclopropyldiketopiperazines and thereof key intermediates.
    Type: Application
    Filed: August 20, 2020
    Publication date: December 3, 2020
    Applicant: F.I.S. - Fabbrica Italiana Sintetici S.P.A.
    Inventors: Pierluigi PADOVAN, Kexia Lou
  • Process for the preparation of cyclopropyldiketopiperazines and of a key intermediate of DS-5272
    Patent number: 10836778
    Abstract: Object of the present invention is an improved process for the preparation of cyclopropyldiketopiperazines and thereof key intermediates.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: November 17, 2020
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Pierluigi Padovan, Kexia Lou
  • EFFICIENT PROCESS FOR THE PREPARATION OF SITAGLIPTIN THROUGH A VERY EFFECTIVE PREPARATION OF THE INTERMEDIATE 2,4,5-TRIFLUOROPHENYLACETIC ACID
    Publication number: 20200157109
    Abstract: Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
    Type: Application
    Filed: May 15, 2018
    Publication date: May 21, 2020
    Applicant: F.I.S. - FABBRiCA ITALIANA SINTETICI S.P.A.
    Inventors: Ottorino DE LUCCHI, Pierluigi PADOVAN, Elena BRASOLA
  • PROCESS FOR THE PREPARATION OF CYCLOPROPYLDIKETOPIPERAZINES AND OF A KEY INTERMEDIATE OF DS-5272
    Publication number: 20190389881
    Abstract: Object of the present invention is an improved process for the preparation of cyclopropyldiketopiperazines and thereof key intermediates.
    Type: Application
    Filed: January 15, 2018
    Publication date: December 26, 2019
    Applicant: F.I.S. - Fabbrica Italiana Sintetici S.p.A.
    Inventors: Pierluigi PADOVAN, Kexia Lou
  • Process for the preparation of enclomiphene citrate having needle shaped crystal habit
    Patent number: 10364212
    Abstract: An improved and well reproducible process for the preparation of Enclomiphene citrate having needle shaped crystal habit is provided. It is also related to a solid form of Enclomiphene citrate.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: July 30, 2019
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A.
    Inventors: Lorenzo Caruana, Pierluigi Padovan, Claudio Dal Santo
  • PROCESS FOR THE PREPARATION OF ENCLOMIPHENE CITRATE HAVING NEEDLE SHAPED CRYSTAL HABIT
    Publication number: 20180362444
    Abstract: An improved and well reproducible process for the preparation of Enclomiphene citrate having needle shaped crystal habit is provided. It is also related to a solid form of Enclomiphene citrate.
    Type: Application
    Filed: April 22, 2016
    Publication date: December 20, 2018
    Inventors: Lorenzo CARUANA, Pierluigi PADOVAN, Claudio DAL SANTO
  • STABLE SOLID FORMS OF ENCLOMIPHENE AND ENCLOMIPHENE CITRATE
    Publication number: 20170349533
    Abstract: The present invention refers to new solid forms of Enclomiphene citrate and Enclomiphene base, processes for preparing thereof and uses.
    Type: Application
    Filed: May 19, 2017
    Publication date: December 7, 2017
    Inventors: Pierluigi PADOVAN, Lorenzo CARUANA, Nicolas TESSON
  • Stable solid forms of enclomiphene and enclomiphene citrate
    Patent number: 9822063
    Abstract: The present invention refers to new solid forms of Enclomiphene citrate and Enclomiphene base, processes for preparing thereof and uses.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: November 21, 2017
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A
    Inventors: Pierluigi Padovan, Lorenzo Caruana, Nicolas Tesson
  • Process for the preparation of Efavirenz using keton solvents
    Patent number: 9670169
    Abstract: An improved process for the preparation of Efavirenz which avoids the distillations of the solvents is provided.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: June 6, 2017
    Assignee: F.I.S.—FABRICA ITALIANA SINTETICI S.P.A.
    Inventors: Francesco Fontana, Pierluigi Padovan, Marco Prebianca
  • PROCESS FOR THE PREPARATION OF EFAVIRENZ USING KETON SOLVENTS
    Publication number: 20170008861
    Abstract: An improved process for the preparation of Efavirenz which avoids the distillations of the solvents is provided.
    Type: Application
    Filed: May 7, 2015
    Publication date: January 12, 2017
    Inventors: Francesco FONTANA, Pierluigi PADOVAN, Marco PREBIANCA