Abstract: The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2-10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.

Abstract: Vessel comprising a hull having near a bottom a cavity for receiving a mooring buoy, a lifting device being placed on the hull comprising a cable that extends through the cavity to a weight that is situated below the bottom of the vessel, the mooring buoy being attached to the cable, the mooring buoy carrying mooring lines that are connected to a sea bed and being receivable in the cavity for coupling with the turret, the mooring buoy comprising a central shaft through which the cable passes, the buoy being movable relative to the cable in a length direction of the cable, wherein the weight is located on the cable at or below the buoy, a stopper being provided on the cable for engaging with the buoy and for blocking relative movement of the buoy and the cable, the stopper being fixed to the cable near an upper or a lower end of the buoy.

Abstract: A vessel includes a hull, a shaft extending from an upper part of the hull to a bottom of the hull, a turret being rotatably supported in the shaft via a turret bearing, a manifold support structure carrying one or more conduits being rotatably supported on the turret via a manifold bearing. The turret includes a cavity for receiving a mooring buoy carrying one or more risers and one or more vertically displaceable actuation members near the manifold bearing for vertically displacing the manifold support structure relative to the turret between a rotational position in which the manifold support structure can rotate relative to the turret via the manifold bearing and a locked position in which the bearing support structure is rotationally locked relative to the turret.

Abstract: The present invention relates to a method for preparing poloxamer-protein particles. It also relates to poloxamer-protein particles obtainable by this method, dispersion thereof, and their use in methods of encapsulation, in particular of microencapsulation.

Abstract: An apparatus and method is provided for near real-time, bi-layer segmentation of foreground and background portions of an image using the color and infrared images of the image. The method includes illuminating an object with infrared and visible light to produce infrared and color images of the object. An infrared mask is produced from the infrared image to predict the foreground and background portions of the image. A trimap is produced from the color image to define the color image into three distinct regions. A closed-form natural image matting algorithm is applied to the images to determine the foreground and background portions of the image.

Abstract: A color filter array is provided that includes a mosaic of two new filters that are sensitive only to a narrow band of near infrared light centered around 850 nm. In one embodiment, the color filter array is provided for a two-dimensional CMOS sensor device, the filter array including a filter arrangement of green, blue, green, red, infrared and infrared color filters. A de-mosaicing process can be used to create a full-resolution color image from the image detected by the CMOS sensor through the color filter array.

Abstract: The invention relates to a composition comprising in an aqueous phase, particles having a diameter in the range of 20 to 500 nm, said particles containing:—an oil phase;—in said oil phase,—an aqueous droplet, or—a nanocapsule (NC) comprising:—an aqueous core, and—a polymeric shell or a shell composed of an amphiphilic substance; and—a surfactant. This composition is particularly useful for encapsulating hydrophilic and/or lipophilic substances.

Abstract: The invention relates to nanocapsules with a liquid lipidic core and a solid lipidic shell, the lipidic core being loaded with at least one water-soluble or water-dispersible ingredient, said ingredient being present in the form of a reverse micellar system.

Abstract: The present invention relates to a method for use in the preparation of nanocapsules which have a liquid lipid core and a solid lipid shell and which are loaded with at least one active agent, wherein said method comprises at least the steps consisting in providing a microemulsion formulated by phase inversion of an emulsion, providing a second composition, distinct from said microemulsion and completely or partly formed from at least one active agent, placing said microemulsion in the presence of said second composition under conditions suitable for the interaction of said active agent with said microemulsion and annealing said microemulsion having interacted with said active agent in such a way as to obtain said nanocapsules. The invention also relates to a corresponding kit.

Abstract: The present invention relates to peptides which impair PBX-dependent regulation of gene transcription. In particular, the invention provides the use of a peptide comprising the amino acid sequence X1 X2 X3 W M X4 X5 X6 X7, wherein the sequence X1 to X7 is an amino acid sequence comprising at least 9 amino acids, which may optionally be interrupted by one or two amino acid residues between one or more of the 9 amino acid positions defined herein; X1 is selected from W, T, PE, KQI, VV, PQT, H, RI and absent; X2 is an amino acid with an aromatic side chain; X3 is P or D; X4 is an amino acid with a basic side chain; X5 is an amino acid with a charged side chain; X6 is an amino acid with a charged side chain; and X7 is an amino acid with a basic side chain or Serine; in the manufacture of a medicament for treating or preventing a disorder in which aberrant cell division occurs.

Abstract: The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2-10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.

Abstract: The present invention relates to a method for preparing particles, notably particles encapsulating an active substance. It also relates to particles obtainable by this process, dispersion thereof, and their use as a vehicle for pharmaceutical, cosmetic, diagnostic, veterinary, phytosanitary active substances or processed foodstuff.

Abstract: The invention relates to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of at least 90 weeks, a therapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres used preferably contain 5-fluorouracile of the tumor, by intratissular injection. The radiotherapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.

Abstract: Use of a colloidal carrier for the manufacture of a medicament for inhibiting P-glycoprotein, wherein said colloidal carrier:—encapsulates or adsorbs a pharmacologically active substance, and—comprises P-glycoprotein inhibitor surfactants bound to the colloidal carrier surface.

Abstract: The present invention provides microspheres intended to be administered by injection comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its release, wherein they are free of any trace of organic solvent and they can be obtained according to a coating method involving bringing the active ingredient and the coating agent into contact, with stirring, in a supercritical fluid, said coating agent being soluble in this supercritical fluid.

Abstract: Microparticles including a biodegradable, biocompatible material having at least a portion of surface adapted to adhere to cells of interest or fragments thereof; and at least one substance active on the cells or their environment upon implantation of the microparticles in a patient associated with the material wherein the substances is released in a controlled and/or extended manner.

Abstract: The invention relates to the use of biodegradable microspheres that release a radiosensitizing anticancer agent for producing a medicament to be used simultaneously with, separately from or spread over time with a radiotherapy, for treating glioblastoma. The use of said biodegradable microspheres according to the invention results in a patient survival time of least 90 weeks, a thereapeutically effective concentration being maintained in the parenchymatous area throughout this time. The microspheres used prefereably contain 5-fluorouracile of the tumor, by intratissular injection. The radiothereapy targeting the tumorous mass is dosed at 60 Gy over approximately 6 weeks. The invention also relates to a method for producing the biodegradable microspheres by emulsion-extraction, and to a suspension containing the biodegradable microspheres obtained using this method.

Abstract: Use of biodegradable microspheres releasing an anticancer agent for the manufacture of a medicament for the use in the treatment in humans of inoperable tumors, wherein biodegradable microspheres are administered by stereotactic injection directly into the tumor, into the peritumoral area or at the same time into the tumor and the peritumoral area.

Abstract: The invention concerns a novel method for preparing, by solvent extraction, PLGA/PLA-type polymer microspheres encapsulating water-soluble substances. The invention also concerns the microspheres obtained by said method.

Abstract: Electric arc monitoring is effected by exploiting the discovery that electric arcs are fractal phenomena in that all essential information that signifies an “arc” is contained in each fractal subset. The fractal subsets are logarithmically distributed over the arc spectrum. Monitoring of arcs is most advantageously effected on a fractal subset of low logarithmic order where the amplitude is higher pursuant to the 1/f characteristic of electric arcs, where cross-induction among neighboring circuits is lower, and where travel between the arc and the arc signature pickup is longer that at the high frequency customary for electric arc detection. Fractal subset information reduces the danger of false alarms. Arc signature portions may be processed in out of phase paths or treated as modulated carriers for monitoring.