Patents by Inventor Pierre Bartsch

Pierre Bartsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions of pyrimidine-2,4,6-triones
    Patent number: 8044035
    Abstract: A trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a water-soluble cyclodextrin derivative has improved solubility.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: October 25, 2011
    Assignee: Universite De Liege
    Inventors: Pierre Bartsch, Didier Cataldo, Richard Endele, Brigitte Evrard, Jean-Michel Foidart, Hans-Willi Krell, Gerd Zimmermann
  • PHARMACEUTICAL COMPOSITIONS OF PYRIMIDINE-2,4,6-TRIONES
    Publication number: 20100261672
    Abstract: A trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a water-soluble cyclodextrin derivative has improved solubility.
    Type: Application
    Filed: May 27, 2009
    Publication date: October 14, 2010
    Inventors: Pierre Bartsch, Didier Cataldo, Richard Endele, Brigitte Evrand, Jean-Michel Foidart, Hans-Willi Krell, Gerd Zimmermann
  • Pharmaceutical compositions of pyrimidine-2,4,6-triones
    Publication number: 20070191404
    Abstract: It was surprisingly found that a-trioxopyrimidine-cyclodextrin-complex formed of a trioxopyrimidine derivative represented by the below-described formula (I) and a water-soluble cyclodextrin (further abbreviated as CD) exhibits enhanced water solubility, excellent stability, and low topical stimulation and is useful as a therapeutic agent. Accordingly, the present invention provides a trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a cyclodextrin, preferably ?-, ?- or ?-cyclodextrin or a water-soluble cyclodextrin derivative (water-soluble being defined as a solubility of at least 0.5 gr/100 ml water at 25° C.), wherein the trioxopyrimidine derivative is represented by formula (I). It was furthermore found that such a trioxopyrimidine complex with cyclodextrin and an adjuvant such as L-lysine or L-arginine show improved water solubility and bioavailability, excellent stability, and low topical stimulation and is useful as a therapeutic agent.
    Type: Application
    Filed: March 31, 2005
    Publication date: August 16, 2007
    Inventors: Pierre Bartsch, Didier Cataldo, Richard Endele, Brigitte Evrard, Jean-Michel Foidart, Hans-Willi Krell, Gerd Zimmermann