Abstract: Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation.

Abstract: A surgical training and rehearsal system, including at least one valve; at least one pump fluidically coupled with the at least one valve; a tank for storing a fluid fluidically coupled with the at least one valve; a heater in fluid communication with the tank configured to heat the fluid stored in the tank; at least one surgical approach tube having a proximal end sealingly covered by a self-healing elastomeric membrane, the surgical approach tube being fluidically coupled with the at least one valve, tank and pump; an exit port fluidically coupled with a distal end of the surgical approach tube; and an anatomical cartridge fluidically coupled with the exit port, the anatomical cartridge including at least one tortuous path whose shape, size and mechanical properties mimic those of a portion of a human circulatory system.

Abstract: A surgical simulation device is disclosed that allows a structural heart disease (SHD) team, including a surgeon and an imaging specialist to perform a simulated cardiac intervention procedure using a patient-specific model that replicates biomechanical and echogenic properties of a specific patient to be operated on. The surgical simulation device can include a station with a tank for receiving a patient-specific cartridge with the patient-specific model. The device can also include an esophageal access system in the station and a vascular access system that couples to an access port of the station.

Abstract: A method for processing data relating to a radiological examination of a patient by way of a determining device, comprises the steps of acquiring doses (Ci, ti) measured at a plurality of times ti, storing these time-stamped measurements of radiation doses, and acquiring at least one DICOM digital file containing information on the examination, wherein the method comprises the following steps: acquiring and storing at least one DICOM digital file delivered by the tomograph during or after a tomography; acquiring and storing time-stamped measurements of the doses detected via a scintillating fiber placed on the table, and time-stamped movements of the table; interpolating the measurements (Ci, ti) with data of the image (DICOM) in a common interpolated space and constructing a table (Ck, DICOMk) in the interpolated space; and determining a table of the average dose levels Tz in each slice T depending on the data (DICOMk, Ck).

Abstract: A swivel arrangement including high voltage electrical swivels concentrically arranged around a common axis, each swivel including: a first annular housing part and a second annular housing part together defining an internal annular volume; a first solid electrical conductor stationary with respect to the first annular housing part, and a second solid electrical conductor stationary with respect to the second annular housing part, wherein the first and second electrical conductors are arranged within the internal annular volume for making conductive sliding contact with each other, wherein the first annular housing part and second annular housing part are rotatable relative to each other around the common axis while the first and second electrical conductors are in sliding contact with each other; wherein the swivels are arranged concentrically around the common axis so that a plane normal to the axis intersects at least two, preferably three, of the electrical swivels.

Abstract: The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.

Abstract: A surgical simulation device is disclosed that allows a structural heart disease (SHD) team, including a surgeon and an imaging specialist to perform a simulated cardiac intervention procedure using a patient-specific model that replicates biomechanical and echogenic properties of a specific patient to be operated on. The surgical simulation device can include a station with a tank for receiving a patient-specific cartridge with the patient-specific model. The device can also include an esophageal access system in the station and a vascular access system that couples to an access port of the station.

Abstract: The present invention concerns modified nucleobases, nucleosides, deoxynucleosides, and/or their derivatives, nanocapsules comprising them, hydrogels and oleogels comprising said nanocapsules or said above-mentioned compounds and their uses, in particular their pharmaceutical uses.

Abstract: Disclosed is a mooring line connector assembly for connecting a mooring line to a floating structure, including: a tubular housing connectable to the floating structure, having a lower housing end and an upper housing end with an inner circumference; a connector body extending along a connector axis, having an upper connector body end and a lower connector body end connected to the mooring line; a guiding body rotatably arranged on the connector body to be freely rotatable around the connector body and the connector axis, including first rotation unit on an outer surface of the guiding body and a guiding part having an outer circumference at an upper guiding body end; and second rotation unit arranged on an inner surface of the tubular housing, arranged for engaging the first rotation unit.

Abstract: The present invention relates to a method for preparing poloxamer-protein particles. It also relates to poloxamer-protein particles obtainable by this method, dispersion thereof, and their use in methods of encapsulation, in particular of microencapsulation.

Abstract: A mooring assembly includes: a mooring buoy having a central axis, an upper ring portion providing an upper abutment surface; a mooring structure including a cavity with a wall receiving the mooring buoy; and a buoy locking system near the cavity engaging with the upper ring portion for locking the mooring buoy to the turret mooring structure and including at least two locking devices attached to the mooring structure, each locking device having a locking dog connected to a force member for axial displacement and exerting an upward force on the upper abutment surface. The mooring buoy includes a lower abutment surface. The locking system includes an engagement member below the locking dog, engaging with the lower abutment surface and exerting a downward force. The buoy at positions axially above the upper abutment surface situated at an axial clearance from the cavity wall.

Abstract: Disclosed is a mooring line connector assembly for connecting a mooring line to a floating structure, including: a tubular housing connectable to the floating structure, having a lower housing end and an upper housing end with an inner circumference; a connector body extending along a connector axis, having an upper connector body end and a lower connector body end connected to the mooring line; a guiding body rotatably arranged on the connector body to be freely rotatable around the connector body and the connector axis, including first rotation unit on an outer surface of the guiding body and a guiding part having an outer circumference at an upper guiding body end; and second rotation unit arranged on an inner surface of the tubular housing, arranged for engaging the first rotation unit.

Abstract: An arrangement for mooring, loading and unloading of a vessel, includes a structure connected to the seabed and a Y-formed yoke for connecting the vessel to the structure, the structure including a stationary inner element adapted to be fixedly connected to the sea bed and an outer element having a rotatable fastening to the inner element, the outer element having a connector for fixing the yoke, wherein the yoke is provided with a pitch articulation to fix the first or mutual end of the yoke to the connector of the outer element and a roll articulation positioned between the pitch articulation and the first and second leg to allow the legs to rotate along the longitudinal axis of the yoke with respect to the pitch articulation.

Abstract: A method of repairing tissue includes implanting into a patient a therapeutically effective amount of a pharmaceutical composition including microparticles including a biodegradable, biocompatible material having cells of interest or fragments thereof adhered to at least a portion of a surface; and at least one substance active on the cells or their environment upon implantation of the microparticles in a patient associated with the material wherein the substances is released in a controlled or extended manner.

Abstract: The invention relates to a composition comprising in an aqueous phase, particles having a diameter in the range of 20 to 500 nm, said particles containing:—an oil phase;—in said oil phase,—an aqueous droplet, or—a nanocapsule (NC) comprising:—an aqueous core, and—a polymeric shell or a shell composed of an amphiphilic substance; and—a surfactant. This composition is particularly useful for encapsulating hydrophilic and/or lipophilic substances.

Abstract: A composition, an encapsulated composition and/or nanoparticles comprising at least one essential oil having a large spectrum antibacterial, antiparasitic, antifungal activity and/or a plant antipathogen, optionally at least one antibiotic and optionally a pharmaceutically acceptable carrier is disclosed. Methods for treating infectious diseases and especially bacterial, parasitic, fungal and/or plant infectious by using this composition, encapsulated composition and/or nanoparticles are also disclosed.

Abstract: An arrangement for mooring, loading and unloading of a vessel, includes a structure connected to the seabed and a Y-formed yoke for connecting the vessel to the structure, the structure including a stationary inner element adapted to be fixedly connected to the sea bed and an outer element having a rotatable fastening to the inner element, the outer element having a connector for fixing the yoke, wherein the yoke is provided with a pitch articulation to fix the first or mutual end of the yoke to the connector of the outer element and a roll articulation positioned between the pitch articulation and the first and second leg to allow the legs to rotate along the longitudinal axis of the yoke with respect to the pitch articulation.

Abstract: Turret mooring system for receiving a mooring buoy, includes a turret mooring structure, and a buoy locking system for locking the mooring buoy, whereby the turret mooring system includes an intermediate connection member, which includes the buoy locking system. The intermediate connection member is rotatably suspended from the turret mooring structure. A method of mooring a vessel, including a turret mooring system, is described whereby the turret mooring system is arranged to receive the mooring buoy. The turret mooring system includes a turret mooring structure that is rotatably suspended from the vessel and an intermediate connection member that is rotatably suspended from the turret mooring structure. The method includes the steps of receiving the mooring buoy into the turret mooring system, locking the mooring buoy to the intermediate connection member, and rotating the intermediate connection member and the turret mooring structure with respect to each other.

Abstract: A mooring assembly includes: a mooring buoy having a central axis, an upper ring portion providing an upper abutment surface; a mooring structure including a cavity with a wall receiving the mooring buoy; and a buoy locking system near the cavity engaging with the upper ring portion for locking the mooring buoy to the turret mooring structure and including at least two locking devices attached to the mooring structure, each locking device having a locking dog connected to a force member for axial displacement and exerting an upward force on the upper abutment surface. The mooring buoy includes a lower abutment surface. The locking system includes an engagement member below the locking dog, engaging with the lower abutment surface and exerting a downward force. The buoy at positions axially above the upper abutment surface situated at an axial clearance from the cavity wall.

Abstract: The present invention relates to a liquid lipid core/solid lipid shell capsule surface-functionalized with at least one compound containing at least one amino function, characterized in that the lipid core/lipid shell architecture is on the nanometric scale and in that said compound is covalently bonded to said solid lipid shell via a transacylation reaction. It also relates to a method for preparing such capsules.