Patents by Inventor Pierre Buffet

Pierre Buffet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

USE OF DRUGS THAT STIFFEN MATURE GAMETOCYTES FOR BLOCKING TRANSMISSION OF PLASMODIUM PARASITES

Publication number: 20240024299

Abstract: The spleen clears rigid erythrocytes from the circulation. Drug-induced stiffening of Plasmodium falciparum intra-erythrocytic sexual stages (mature gametocytes) is therefore expected to block the transmission of malaria By screening 13 555 compounds with spleen-mimetic microfilters, the inventors identified 82 compounds that stiffen mature gametocytes. Eight active families were identified, including known anti-malarial, antimicrobial or anticancer agents, amongst others. Hit prioritization based on accessible safety and pharmacokinetics data in humans identified 3 leading candidates. NITD609 displayed killing and stiffening effects (IC50 of 100 and 50 nM, respectively), while TD-6450 and L-THP had a pure or predominant stiffening effect (IC50 of 600 and 5 nM, respectively). These values are lower than or close to peak plasma concentrations in humans. Clinical trials with these strong malaria transmission-blocking candidates are envisioned.

Type: Application

Filed: December 13, 2021

Publication date: January 25, 2024

Inventors: Pierre BUFFET, Papa Alioune NDOUR, Mario CARUCCI, Julien DUEZ
METHOD FOR PREPARING RED BLOOD CELLS FOR INFUSION

Publication number: 20130184685

Abstract: The present invention relates to methods to prepare red blood cells (RBCs) for infusion to a patient. Depletion of RBCs with altered deformability is achieved by filtration through micro-bead filters.

Type: Application

Filed: July 20, 2011

Publication date: July 18, 2013

Applicants: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

Inventors: Pierre Buffet, Guillaume Deplaine, Innocent Safeukui-Noubissi
Proteins involved in cytoadhesion of plasmodium falciparum ring-stage-infected erythrocytes, antibodies which bind to the proteins, and methods for detecting infection, stage of infection and vaccines for protecting against infection

Patent number: 7431936

Abstract: The present invention provides the RSP-1 and RSP-2 proteins which are involved in the cytoadhesion of P. falciparum during ring-stage infection of erythrocytes, antibodies which bind to the proteins, methods of screening for a P. falciparum infection, methods of determining the infective stage of P. falciparum and vaccines for protecting individuals from Plasmodium sp. infections.

Type: Grant

Filed: November 29, 2002

Date of Patent: October 7, 2008

Assignees: Institut Pasteur, Centre National de la Recherche Scientifique

Inventors: Juerg Gysin, Bruno Pouvelle, Artur Scherf, Pierre Buffet
Proteins involved in cytoadhesion of plasmodium falciparum ring-stage-infected erythrocytes, antibodies which bind to the proteins, and methods for detecting infection, stage of infection and vaccines for protecting against infection

Publication number: 20060240491

Abstract: The present invention provides hybridomas and antibodies which specifically react with native P. falciparum at a surface of ring stage infected erythrocytes and uses thereof.

Type: Application

Filed: March 16, 2006

Publication date: October 26, 2006

Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scient.

Inventors: Juerg Gysin, Bruno Pouvelle, Artur Scherf, Pierre Buffet
Proteins involved in cytoadhesion of plasmodlum falciparum ring-stage-infected erythrocytes, antibodies which bind to the proteins, and methods for detecting infection, stage of infection and vaccines for protecting against infection

Publication number: 20050054828

Abstract: The present invention provides the RSP-1 and RSP-2 proteins which are involved in the cytoadhesion of P. falciparum during ring-stage infection of erythrocytes, antibodies which bind to the proteins, methods of screening for a P. falciparum infection, methods of determining the infective stage of P. falciparum and vaccines for protecting individuals from Plasmodium sp. infections.

Type: Application

Filed: September 10, 2004

Publication date: March 10, 2005

Applicant: INSTITUT PASTEUR

Inventors: Juerg Gysin, Bruno Pouvelle, Artur Scherf, Pierre Buffet
Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A

Patent number: 6855323

Abstract: The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.

Type: Grant

Filed: February 21, 2002

Date of Patent: February 15, 2005

Assignee: The United States of America as represented by the Department of Health and Human Services

Inventors: Artur Scherf, Louis H. Miller, Benoit Gamain, Dror I. Baruch, Pierre Buffet, Christine Scheidig, Jurg Gysin, Bruno Pouvelle, Nobutaka Fujii, Joseph Smith
Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A

Publication number: 20040062769

Abstract: The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.

Type: Application

Filed: February 21, 2002

Publication date: April 1, 2004

Inventors: Arthur Scherf, Louis H. Miller, Benoit Gamain, Dror I. Baruch, Pierre Buffet, Christine Scheidig, Jurg Gysin, Bruno Pouvelle, Nobutaka Fujii, Joseph Smith
Proteins involved in cytoadhesion of plasmodium falciparum ring-stage-infected erythrocytes, antibodies which bind to the proteins, and methods for detecting infection, stage of infection and vaccines for protecting against infection

Publication number: 20040018569

Abstract: The present invention provides the RSP-1 and RSP-2 proteins which are involved in the cytoadheion of P. falciparum during ring-stage infection of erythrocytes, antibodies which bind to the proteins, methods of screening for a P. falciparum infection, methods of determining the infective stage of P. falciparum and vaccines for protecting individuals from Plasmodium sp. infections.

Type: Application

Filed: November 29, 2002

Publication date: January 29, 2004

Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scientifique

Inventors: Juerg Gysin, Bruno Pouvelle, Artur Scherf, Pierre Buffet
Proteins involved in cytoadhesion of plasmodlum falciparum ring-stage-infected erythrocytes, antibodies which bind to the proteins, and methods for detecting infection, stage of infection and vaccines for protecting against infection

Publication number: 20020055183

Abstract: The present invention provides the RSP-1 and RSP-2 proteins which are involved in the cytoadhesion of P. falciparum during ring-stage infection of erythrocytes, antibodies which bind to the proteins, methods of screening for a P. falciparum infection, methods of determining the infective stage of P. falciparum and vaccines for protecting individuals from Plasmodium sp. infections.

Type: Application

Filed: May 31, 2001

Publication date: May 9, 2002

Applicant: INSTITUT PASTEUR

Inventors: Juerg Gysin, Bruno Pouvelle, Artur Scherf, Pierre Buffet