Abstract: The present invention relates generally to the field of cancer therapy and prophylaxis. More particularly, the present invention provides growth factor antagonists which inhibit the growth of cancers including tumors and pre-cancerous tissue. Even more particularly, the present invention is directed to antagonists of vascular endothelial growth factor-B and their use to inhibit the growth of cancer including tumor tissue and pre-cancerous tissue.

Abstract: The present invention relates generally to the field of cancer therapy and prophylaxis. More particularly, the present invention provides growth factor antagonists which inhibit the growth of cancers including tumors and pre-cancerous tissue. Even more particularly, the present invention is directed to antagonists of vascular endothelial growth factor-B and their use to inhibit the growth of cancer including tumor tissue and pre-cancerous tissue.

Abstract: A method for collectively delivering electronically certified credentials is disclosed. In one aspect, the method includes a) collecting personal data related to credential recipients and including a valid electronic mail address, b) collecting data related to each credential to be delivered to each recipient at a granting authority, c) sending to a centralized server of a certifying authority the collected data of each recipient, the data being stored in a centralized database, d) sending an personalized e-mail corresponding to each recipient, the e-mail including a link to the centralized server, for approval of the data related to the each recipient, and e) activation of the electronic credential.

Abstract: There is described a module for detecting an electronic file, the module embodied on a computer readable medium and configured for: receiving a portion of a file and extracting content from the portion; applying an initial hashing function numerous times to the content, the initial hashing function being applied to each one of a plurality of blocks of elements within the content and resulting in a representation for each one of the blocks; selecting one of the representations from multiple representations as an initial imprint for the file portion; comparing the initial imprint to contents of a first memory containing a plurality of detection imprints for known electronic files to be detected, the detection imprints having been created using at least the initial hashing function; and determining a match when the initial imprint corresponds to a detection imprint in the first memory.

Abstract: The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothielial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B.

Abstract: The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothelial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular, the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B.

Abstract: The present invention relates generally to the field of cancer therapy and prophylaxis. More particularly, the present invention provides growth factor antagonists which inhibit the growth of cancers including tumors and pre-cancerous tissue. Even more particularly, the present invention is directed to antagonists of vascular endothelial growth factor-B and their use to inhibit the growth of cancer including tumor tissue and pre-cancerous tissue.

Abstract: A system for generating addresses for a digital signal processor in which the program instructions include a code for accessing a memory associated with said processor. An address calculation circuit calculates each access address to the memory on the basis of operation codes designated by the address generation code of one of the instructions and of the content of one address register selected from said address registers. Each address generation code defines an operation code to be sent to the calculation circuit. Each of the address registers is further associated with a configuration register designated at the same time as the address register by the address generation code, and each of the configuration registers contains a set of predefined operation codes, each adapted to command a predetermined calculation operation in the calculation circuit.

Abstract: The program instructions include a code for generating addresses for accessing one memory associated with said processor. An address calculation circuit calculates each access address to said memory on the basis of operation codes designated each time by the address generation code of the instructions and of the content of one address register selected from said address registers, and its associated offset and/or a modulo registers. Each address generation code of each instruction define an operation codes to be sent to said calculation circuit. Each of said address registers is further associated with a configuration register designated at the same time as said address register by said address, generation code, each of said configuration registers contains a set of predefined operation codes, each adapted to command a predetermined calculation operation in said calculation circuit and to be transferred to said calculation means, according to said address generation code.

Abstract: According to the invention, a torque-transmitting assembly is described. A female coupling member defines a shape with a tapered bore. A radially flexible sleeve member has a wall with a tapered exterior surface, received within the bore, and an inner surface defining a through-bore. An elongated shaft member made of super-elastic alloy has an outer surface that is received within the through-bore. Relative motion among at least two of the members causes the inner surface to contact the outer surface, inducing a super-elastic activation in the shaft, simultaneously securing the members together in a fixed relative position. The radially flexible sleeve member has a plurality of collet fingers, which preferably contact the shaft at discrete locations. It is further preferred that the super-elastic activation in the shaft occurs as a result of the discrete contact thereby changing the cross-sectional shape of the shaft, which is generally non-circular, e.g., polygonal, in a further preferred form.

Abstract: The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothelial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B.

Abstract: The present invention relates to a screening method for identifying a substance for the treatment of bone disorders that are associated with reduced bone mass in which the substance is tested for its ability to upregulate the expression of Fra-1 or to modulate the expression of a Fra-1 target gene in osteoblasts where the upregulation or modulation results in an increased bone formation in vivo. The identified osteoinductive compounds and DNA molecules encoding biologically active Fra-1 molecules can be used for the therapy of bone disorders characterized by a circumscribed or systemic reduction of bone mass.

Abstract: According to the invention, a torque-transmitting assembly is described. A female coupling member defines a shape with a tapered bore. A radially flexible sleeve member has a wall with a tapered exterior surface, received within the bore, and an inner surface defining a through-bore. An elongated shaft member made of super-elastic alloy has an outer surface that is received within the through-bore. Relative motion among at least two of the members causes the inner surface to contact the outer surface, inducing a super-elastic activation in the shaft, simultaneously securing the members together in a fixed relative position. The radially flexible sleeve member has a plurality of collet fingers, which preferably contact the shaft at discrete locations. It is further preferred that the super-elastic activation in the shaft occurs as a result of the discrete contact thereby changing the cross-sectional shape of the shaft, which is generally non-circular, e.g., polygonal, in a further preferred form.

Abstract: The unit makes it possible to form and cut a sheet (14) made of flexible material, such as paper, cardboard or a plastic medium. It comprises several cutting boxes (2) each having a circular knife (5) and at least one guillotine (27). The cutting boxes (2) are fixed adjustably to a guide bar (3) extending transversely to the direction of movement of the sheet (14), and the circular knives (5) are removably fixed to the said cutting boxes. The forward movement of the sheet (14) and the movement of the guillotine or guillotines can be controlled numerically.

Abstract: A high-strength hybrid component including a relatively soft first part made of a composite material including an organic matrix reinforced with fibers, a relatively hard second part made of metal, metal alloy, or ceramic, and a transition layer made of a composite material including a matrix of a material that is weldable to the hard part and fibers that are extensions of the fibers of the soft part. The transition layer matrix and the hard part may be formed by deposition of molten material on to the fiber preform of the soft part using flame, electric arc, or plasma. The resin matrix of the soft part is impregnated into the preform and polymerized afterwards. Alternatively, the hard part may be machined to shape and welded to the transition layer before completing the soft part.

Abstract: A method and apparatus for presenting information using an electronic display. Information stored in a source format is retrieved from a source device. The information is converted the source format to a uniform serial stream format. The converted information is presented on the display by sequentially flashing words on the display while presenting static elements to help a user navigate through the information.

Abstract: A broadband array antenna which delivers an axisymmetric main lobe. The antenna includes patches arranged with an interruption of periodicity in one of the planes and is corner-fed by tree like feed lines from a central point of energization. Opposite each path is a parasitic element for broadening the band. This device can be used in particular with measurement radar.

Abstract: In an illustrative embodiment, an audio/video conferencing system comprises two or more audio/video terminals, in which the transmitted and/or received audio is automatically adjusted to provide synchronization between audio and video during periods of monologue (i.e., single talker active for significant duration). During interactive periods in which more than one talker is active, the audio delay is automatically adjusted to be less than the video delay, thus improving audio conference quality.

Abstract: A linked multilayer woven fabric for use in the production of structural composite materials has a base weave comprising twenty-eight weft yarns which are distributed in eight columns containing alternately four superimposed yarns and three superimposed yarns such that they are in a staggered arrangement on seven levels, and twelve warp yarns which are arranged in four parallel planes each containing three superimposed parallel warp yarns.

Abstract: The invention provides a high-strength hybrid component comprising a relatively soft first part -made of a composite material consisting of an organic matrix reinforced with fibres, a relatively hard second part made of metal, metal alloy or ceramic, and a transition layer made of a composite material consisting of a matrix of a material which is weldable to the hard part and fibres which are extensions of the fibres of the soft part. The transition layer matrix and the hard part may be formed by deposition of molten material on to the fibre preform of the soft part, using flame, electric arc or plasma, and the resin matrix of the soft part is impregnated into the preform and polymerized afterwards.Alternatively, the hard part may be machined to shape and welded to the transition layer before completing the soft part.