Abstract: The invention relates to a capped cyclodextrin-hydrophobic moiety conjugate, to a supramolecular polymer formed of capped cyclodextrin-hydrophobic moiety conjugates according to the invention and to a siRNA-cyclodextrin complex comprising a supramolecular polymer according to the invention. The invention also relates to a method for manufacturing the capped cyclodextrin-hydrophobic moiety conjugate, the supramolecular polymer, the siRNA-cyclodextrin complex according to the invention. The capped cyclodextrin-hydrophobic moiety conjugate of the invention comprises a capped cyclodextrin group and at least one hydrophobic moiety bound by a first linker to one of the carbon atoms of the cap. The invention can be used for various applications in particular in the pharmaceutical field.

Abstract: A processing system and method are provided for reconstituting a block of pixels from bins generated by a Mojette Transform, using a processing and calculation unit (UTC), a bin memory (MB), and a pixel memory (MP). The unit is configured to carry out the operations of reconstructing the pixels, which are performed by reading the bins in the bin memory, reading the reconstructed pixels in the pixel memory, and writing the reconstructed pixels in the pixel memory, such that the steps of reconstructing the pixels do not include an operation of writing bins in the bin memory.

Abstract: A method for reconstructing a data block of size N is proposed. The data block was encoded using an erasure code to generate a set of Ns systematic symbol vectors and a set of Np parity projection vectors from a mapping of the data block onto a two-dimensional convex support. The method comprises: for each input vector that contains at least an erasure, updating the value of each erased symbol to a predetermined value; mapping the Ns input vectors with updated values onto the two-dimensional convex support, generating a reconstruction projection vector from the mapping of the Ns input vectors with updated values onto the two-dimensional convex support using an encoding projection direction; and generating an updated parity projection vector from the reconstruction projection vector and the parity projection vector generated using said encoding projection direction.

Abstract: The invention relates to a capped cyclodextrin-hydrophobic moiety conjugate, to a supramolecular polymer formed of capped cyclodextrin-hydrophobic moiety conjugates according to the invention and to a siRNA-cyclodextrin complex comprising a supramolecular polymer according to the invention. The invention also relates to a method for manufacturing the capped cyclodextrin-hydrophobic moiety conjugate, the supramolecular polymer, the siRNA-cyclodextrin complex according to the invention. The capped cyclodextrin-hydrophobic moiety conjugate of the invention comprises a capped cyclodextrin group and at least one hydrophobic moiety bound by a first linker to one of the carbon atoms of the cap. The invention can be used for various applications in particular in the pharmaceutical field.

Abstract: A processing system and method are provided for reconstituting a block of pixels from bins generated by a Mojette Transform, using a processing and calculation unit (UTC), a bin memory (MB), and a pixel memory (MP). The unit is configured to carry out the operations of reconstructing the pixels, which are performed by reading the bins in the bin memory, reading the reconstructed pixels in the pixel memory, and writing the reconstructed pixels in the pixel memory, such that the steps of reconstructing the pixels do not include an operation of writing bins in the bin memory.

Abstract: The invention concerns a processing system and method for reconstituting a block of pixels from bins generated by a Mojette Transform, using a processing and calculation unit (UTC), a bin memory (MB), and a pixel memory (MP). Said unit is configured to carry out the operations of reconstructing the pixels, which are performed by reading said bins in the bin memory, reading the reconstructed pixels in the pixel memory, and writing the reconstructed pixels in the pixel memory, such that the steps of reconstructing the pixels do not include an operation of writing bins in the bin memory.

Abstract: The invention concerns a processing system and method for reconstituting a block of pixels from bins generated by a Mojette Transform, using a processing and calculation unit (UTC), a bin memory (MB), and a pixel memory (MP). Said unit is configured to carry out the operations of reconstructing the pixels, which are performed by reading said bins in the bin memory, reading the reconstructed pixels in the pixel memory, and writing the reconstructed pixels in the pixel memory, such that the steps of reconstructing the pixels do not include an operation of writing bins in the bin memory.

Abstract: A method for reconstructing a data block of size N is proposed. The data block was encoded using an erasure code to generate a set of Ns systematic symbol vectors and a set of Np parity projection vectors from a mapping of the data block onto a two-dimensional convex support. The method comprises: for each input vector that contains at least an erasure, updating the value of each erased symbol to a predetermined value; mapping the Ns input vectors with updated values onto the two-dimensional convex support, generating a reconstruction projection vector from the mapping of the Ns input vectors with updated values onto the two-dimensional convex support using an encoding projection direction; and generating an updated parity projection vector from the reconstruction projection vector and the parity projection vector generated using said encoding projection direction.

Abstract: A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these compounds, and uses for these compounds and compositions, in particular, in transplantation.

Abstract: The present invention pertains “to the use of a PKC inhibitor in the manufacture of a medicament in the treatment or prevention of diabetic complications, where in the PKC inhibitor is one of 3-(1.H.-indol-3-yl)-4-[2-(4-methyl-piperazin-1-yl)-quinazolin-4-yl]-pyrrole-2,5-dione, 3-(1.H.-indol-3-yl)-4-[2-(piperazin-1-yl)-quinazolin-4-yl]-pyrrole-2,5-dione, 3-[3-(4,7-Diaza-spiro [2.5]oct-7-yl)-isoquinolin-1-yl]-4-(7-methyl-1H-indol-3-yl)-pyrrole-2,5-dione or a pharmaceutically acceptable salt thereof.

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these compounds, and uses for these compounds and compositions, in particular, in transplantation.

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: A compound of formula (I) wherein R, R1, and R2, ring A and ring B are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.

Abstract: A compound of formula I wherein R, Ra, Rb, Rc, Rd and Re are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.

Abstract: This invention relates to PKC inhibitors which are able to selectively inhibit e.g. the and optionally 0, isoforms of PKC, and their use in particular in transplantation.

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: The present invention pertains to the use of a PKC inhibitor in the manufacture of a medicament in the treatment or prevention of diabetic complications.

Abstract: Provided are compounds of Formula (I), which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infraction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of (I) are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders or autoimmune diseases e.g.

Abstract: A compound of formula (I) wherein R, R1, and R2, ring A and ring B are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.