Abstract: The present invention relates to the stratification and treatment of patients suffering of cancer. Due to the fact that anti-PD1 therapy targets lymphocytes and the efficiency of anti-cancer therapy is measured by the impact on the tumor cells, the inventors postulated that studying the molecular mechanisms of resistance of anti-PD1 therapy should take into consideration existing intercellular communication between lymphocytes and tumor cells. As exosomes are the carriers for the intercellular transfer of the miRNA responsible of chemoresistance, they herein investigated whether exposure of T cells to anti-PD1 therapy might promote the expression of exosomal miRNA (exomiR) causing the chemoresistance of cancer cells. Surprisingly, they found that anti-PD1 exposure of T-cell promotes an enrichment of exosomal miRNA-4315. They also noted that exosomal miRNA-4315 induced a phenomenon of apopto-resistance to conventional chemotherapies in cancer cells receiving exosomal miRNA-4315.

Abstract: Apparatuses, systems, and methods are described for providing increased detection accuracy. A system for may include a management system, a network, and a sensor device. The sensor device may include a first sensor which captures baseline data and current data associated with the space, a second sensor which detects motion within the space, and a processor which causes the first sensor to capture the baseline data based at least in part upon a predetermined time period having elapsed since detected motion by the second sensor, and further configured to cause the second sensor to capture the current data and perform a comparison operation on the current data and the baseline data.

Abstract: A bezel is provided for a multi-sensor device having a cover and a printed circuit board including a plurality of sensors. The bezel comprises a soft, flexible or resilient body including a first side and a second side, and a plurality of openings for the plurality of sensors or components thereof. The plurality of openings extend between the first and second sides. The first side is adjacent to the cover, and the second side is adjacent to the printed circuit board. The body can be a gasketing body to prevent unwanted materials from entering the housing of the multi-sensor device, and to dampen unwanted vibrations.

Abstract: The present invention relates to an in vitro method for determine the prognosis of the survival time of a patient suffering from a cancer comprising the steps consisting of i) determining the expression level of the couple DNMT3A/ISGF3? in a sample from said patient, ii) comparing said expression level with a predetermined reference value and iii) providing a good prognosis when the expression level is lower than the predetermined reference value and a poor prognosis when the expression level is higher than the predetermined reference value. The invention also relates a compound which is a DNMT3A/ISGF3? antagonist or a compound which is a DNMT3A/ISGF3? gene expression inhibitor for use in the treatment and prevention of cancer.

Abstract: The present invention relates the treatment and prognostic of cancer like glioblastoma. Here, the inventors focused their study on the impact of presence of N6-adenosine methylation in miRNA-200b-3p in samples of patients suffering from glioblastoma multiforme (GBM). Their study was particularly focused on the impact of miRNA-200b-3p and its adenosine methylation on the expression of XIAP. XIAP acts as an anti-apoptotic protein via the inhibition of caspase-3 and -7 activation and high XIAP expression is associated with a poor survival in several solid tumors. Thus, the miR-200b-3p-mediated repression of XIAP mRNA expression appears as a mechanism governing the caspase-3 and -7 activity and the apoptosis. In theory, in the presence of miR-200b-3p, XIAP mRNA expression is repressed and caspase-3 and -7 can be activated to promote apoptosis.

Abstract: An apparatus for simulating an atonic uterine body after childbirth includes a one-piece part, which includes: a flexible body having the shape of an atonic uterine body after childbirth, the flexible body is bendable by hand so that the flexible body reproduces a haptic behavior of an atonic uterine body after childbirth; and a rigid neck extending the flexible body, the rigid neck surrounding an opening of the part, the rigid neck having a rigidity greater than a rigidity of the flexible body. The part defines an outer surface and an inner surface. The inner surface defines an inner cavity of the part, wherein the inner cavity opens out into the outer surface so as to define the opening.

Abstract: Ultra-high field (“UHF”) magnetic resonance imaging (“MRI”) is used to localize the endopiriform nucleus (“EPN”) as a target for neuromodulation treatment. Single or multiple different image contrasts can be used to guide localization of the EPN. Treatment plan data are generated based on the localized EPN, and may include coordinate data, trajectory data, or both, for delivering neuromodulation treatment to the localized EPN.

Abstract: A cryptographic key of a first instance of a group of one or more cloud nodes providing a service is managed. A request to share the cryptographic key with a second instance of a different group of one or more cloud nodes is received. A determination is made whether the second instance is allowed to access the cryptographic key. In response to a determination that the second instance is allowed to access the cryptographic key, the cryptographic key is encrypted with a target key of the second instance and the encrypted cryptographic key is signed using a cryptographic signature of the first instance. The signed encrypted cryptographic key is provided to the second instance.

Abstract: Steel material whose constituent grains comprise a matrix in which precipitates are incorporated, the precipitates comprising at least one metallic element selected from a metallic element M, a metallic element M?, a metallic element M? or mixtures thereof; the microstructure of the steel being such that the grains are equiaxed and the average grain size being such that the average of their largest dimension “Dmax” and/or the average of their smallest dimension “Dmin” is comprised between 10 ?m and 50 ?m. The steel material has optimized, stable and isotropic mechanical properties, in particular so that the steel material can best withstand mechanical and/or thermal stresses.

Abstract: Systems, methods, and storage media for creating an interface between a smart contract to be executed on a decentralized architecture and a user component, the method comprising: receiving code corresponding to the smart contract at an interface server; the interface server parsing an application binary interface (ABI) corresponding to the smart contract; the interface server constructing an enhanced application binary interface (EABI) based on the ABI; and the interface server creating a REST API interface specific to the smart contract based on the EABI.

Abstract: The invention relates to a method for producing a grid made of composite material for straightening an air flow for an aircraft turbine engine. The described method is based on the use of longitudinal members (301) which have recesses (303) to allow the penetration of connecting elements (304) into said recesses during the manufacture of the grid.

Abstract: An air inflow lip of a nacelle for a turbojet of an aircraft, including a cavity defined by a leading edge of the nacelle and by an annular wall, includes an inner wall, an acoustic treatment device, and a pneumatic de-icing device including a de-icing fluid supply device. The inner wall of the air inflow lip includes acoustic boreholes and the pneumatic de-icing device includes a honeycombed de-icing plate mounted inside the cavity on the inner wall of the air inflow lip. Also included are conduits for the circulation of a de-icing fluid and acoustic wells communicating with the acoustic boreholes.

Abstract: Optic fibers are embedded within the body of a casing section making up a wellbore casing string. The optic fibers are used to detect damage or deformation of the casing string over the lifespan of a wellbore.

Abstract: The present invention discloses antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The invention also disclosers immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the invention. The antibodies or immunoconjugates of the invention are used for the treatment of cancer or for diagnostic purposes.

Abstract: A digitizer and processor device for a swept-source optical coherence tomography (SS-OCT) imaging system, comprising: an input configured to receive an OCT signal; a control input configured to receive a k-clock signal; a combiner unit (130) receiving the OCT signal and the k-clock signal configured to output a composite signal; a digitizing unit (60) arranged to convert the composite signal into a digital composite signal (69); a data processing unit (70) arranged to determine a profile of optical density in a sample that generated the OCT signal based on the digital composite signal (69).

Abstract: A cryptographic key of a first instance of a group of one or more cloud nodes providing a service is managed. A request to share the cryptographic key with a second instance of a different group of one or more cloud nodes is received. A determination is made whether the second instance is allowed to access the cryptographic key. In response to a determination that the second instance is allowed to access the cryptographic key, the cryptographic key is encrypted with a target key of the second instance and the encrypted cryptographic key is signed using a cryptographic signature of the first instance. The signed encrypted cryptographic key is provided to the second instance.

Abstract: A pixel circuit for a ultra-low power image sensor, including: an integration node, on which a photodiode current is integrated, a comparator arranged to compare a voltage at the integration node with a reference voltage, a n+1 bits digital memory, a writing pulse signal generator arranged to generate a writing pulse signal, on the basis of the comparator output voltage and on the voltage at a memory node, the start of the pulse triggering the writing of the digital word in the n-bits digital memory part. The comparator includes a switch in series with a current source and arranged to be commanded by the voltage at the memory node so that the switch is open at the end of the pulse, so as to drastically limit the consumption of static power of the pixel circuit during the integration phase.

Abstract: Disclosed are antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding the antibodies. Also disclosed are immunoconjugates comprising the antibodies conjugated or linked to a growth-inhibitory agent, and pharmaceutical compositions comprising the antibodies or immunoconjugates of the invention. The antibodies or immunoconjugates are used for the treatment of cancer or for diagnostic purposes.

Abstract: A method for evaluating skin health is disclosed. The method can be used to select skin treatment regimens, ingredients and compositions.

Abstract: Certain aspects of the present disclosure provide techniques for secure digital key derivation for a ranging session between a first device (e.g., a user equipment (UE)) and a second device (e.g., a vehicle). According to certain aspects, a first device maintains a secure ranging in a secure element (SE) at the first device. The first device further fetches, from the SE, one or more other keys derived from the secure ranging key. The first device further uses the one or more other keys to secure a ranging session between the first device and a second device.