Patents by Inventor Pierre Gans

Pierre Gans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile
    Patent number: 10053396
    Abstract: A process for the specific isotopic labeling of an amino acid selected from Valine (Val), Leucine (Leu), and Isoleucine (Ile), in proteins and biomolecular assemblies by introducing, in a medium containing bacteria overexpressing a protein, an acetolactate derivative of Formula I of the application.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: August 21, 2018
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE JOSEPH FOURIER
    Inventors: Pierre Gans, Jerome Boisbouvier, Isabel Ayala, Olivier Hamelin
  • Labeled chiral alpha-hydroxy ketoacid derivatives, a process for preparing said derivatives and their use
    Patent number: 9784744
    Abstract: The present invention relates to labeled chiral alpha-hydroxy ketoacid derivatives, a process for preparing the derivatives and their use for isotopic labeling of amino acids, in particular, for isotopic labeling of methyl groups of amino acids, and more particularly, for specific isotopic labeling of valine, leucine and isoleucine methyl groups, in proteins and biomolecular assemblies. The invention also concerns a process for analyzing proteins and biomolecular assemblies by NMR spectroscopy including a step of isotopic labeling of amino acids, in particular, valine, leucine and isoleucine, in proteins and biomolecular assemblies to be analyzed by the chiral alpha-hydroxy ketoacid derivatives of the invention. The invention further relates to a kit for isotopic labeling of valine, leucine and isoleucine amino acids, in proteins and biomolecular assemblies including one or more chiral alpha-hydroxy ketoacid derivatives of the invention.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: October 10, 2017
    Assignees: Commissariat a l'Energie Atomique et aux Energies Alternatives, Centre National de la Recherch Scientifique
    Inventors: Michael Plevin, Rime Kerfah, Ombeline Pessey, Jérôme Boisbouvier, Pierre Gans
  • PROCESS FOR THE SPECIFIC ISOTOPIC LABELING OF METHYL GROUPS OF VAL, LEU AND ILE
    Publication number: 20170275216
    Abstract: A process for the specific isotopic labeling of an amino acid selected from Valine (Val), Leucine (Leu), and Isoleucine (Ile), in proteins and biomolecular assemblies by introducing, in a medium containing bacteria overexpressing a protein, an acetolactate derivative of Formula I of the application.
    Type: Application
    Filed: June 13, 2017
    Publication date: September 28, 2017
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNVERSITE JOSEPH FOURIER
    Inventors: Pierre GANS, Jerome BOISBOUVIER, Isabel AYALA, Olivier HAMELIN
  • Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile
    Patent number: 9708228
    Abstract: The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: July 18, 2017
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE JOSEPH FOURIER
    Inventors: Pierre Gans, Jérôme Boisbouvier, Isabel Ayala, Olivier Hamelin
  • LABELED CHIRAL ALPHA-HYDROXY KETOACID DERIVATIVES, A PROCESS FOR PREPARING SAID DERIVATIVES AND THEIR USE
    Publication number: 20150212093
    Abstract: The present invention relates to labeled chiral alpha-hydroxy ketoacid derivatives, a process for preparing the derivatives and their use for isotopic labeling of amino acids, in particular, for isotopic labeling of methyl groups of amino acids, and more particularly, for specific isotopic labeling of valine, leucine and isoleucine methyl groups, in proteins and biomolecular assemblies. The invention also concerns a process for analyzing proteins and biomolecular assemblies by NMR spectroscopy including a step of isotopic labeling of amino acids, in particular, valine, leucine and isoleucine, in proteins and biomolecular assemblies to be analyzed by the chiral alpha-hydroxy ketoacid derivatives of the invention. The invention further relates to a kit for isotopic labeling of valine, leucine and isoleucine amino acids, in proteins and biomolecular assemblies including one or more chiral alpha-hydroxy ketoacid derivatives of the invention.
    Type: Application
    Filed: August 7, 2013
    Publication date: July 30, 2015
    Inventors: Michael Plevin, Rime Kerfah, Ombeline Pessey, Jérôme Boisbouvier, Pierre Gans
  • PROCESS FOR THE SPECIFIC ISOTOPIC LABELING OF METHYL GROUPS OF VAL, LEU AND ILE
    Publication number: 20130122598
    Abstract: The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
    Type: Application
    Filed: January 6, 2010
    Publication date: May 16, 2013
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE JOSEPH FOURIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Pierre Gans, Jerome Boisbouvier, Isabel Ayala, Olivier Hamelin