Abstract: Ectonucleoside triphosphate diphosphohydrolases [NTPDases; EC 3.6.1.5] constitute a family of enzymes which are involved in the metabolism of extracellular nucleotides, catalysing the hydrolysis of the gamma and beta phosphate bonds of triphospho- and diphosphonucleosides (whereas 5′nucleotidases [EC 3.1.3.5] catalyse the hydrolysis of alpha phosphate bond of monophosphonucleosides). These extracellular nucleotides interact with endothelial, epithelial and smooth muscle cells, as well as blood cells and lymphoid cells, to influence the different physiological systems of vertebrates.

Abstract: Data communication apparatus including a port and a control entity. The control entity is operative to establish a connection with a remote entity over a first path and negotiate with the remote entity using in-band signaling over the first path establishment of a second path allowing the exchange of data between the data communication apparatus and the remote entity. The invention presents advantages from the standpoint of ease of implementation and bandwidth and resource savings. The use of an in-band messaging protocol to negotiate a establishment of the second path can be implemented generally in a straight forward manner. At the same time, the ability to transfer at least part of the connection to the second path avoids the drawbacks that would arise if that part of the connection were constrained to the first path. This feature allows the operator to take advantage of benefits provided by the second path but not available to the first path.

Abstract: C8-substituted purine nucleotide analogs, such as ATP analogs, and their use is described, including their use as inhibitors of NTPDases and thereby as tools to modulate the conversion of nucleotides into nucleoside derivatives, and thus modulate the levels of these compounds. Such modulation further provides for the modulation of the activity and function of many processes which are affected by these compounds.

Abstract: A router includes a computer-readable medium storing routing information for destination within a network. A verification module executing within an operating environment provided by the router validates data of a network communication. A reconciliation manager displays a user interface for reconciling any invalid data. A routing module forwards the network communication to a destination according to the routing information.

Abstract: A router includes a computer-readable medium storing routing information mapping destinations to routes within a network. A storage manager software module executing within an operating environment provided by the router receives a network communication including an asset having a pixel data and non-pixel data, and stores the asset to a storage device. A validation software module validates the non-pixel data in parallel with the storage of the asset. A routing module forwards the storage asset to a network destination in accordance with the routing information upon the validation of the non-pixel data.

Abstract: A communication format and protocol is described for routing and storage “asset” within a computer network. The assets conform to a format in which a first data structure that stores asset meta information to control routing of the asset through a medical imaging network. A second data structure that stores medical imaging information received from a medical imaging modality. A third data structure that stores pixel data received from the medical imaging modality. A fourth data structure that stores patch data that includes modifications to the medical imaging information. A fifth data structure that stores error detection and correction information.

Abstract: A router includes a computer-readable medium storing routing information mapping destinations to routes within a medical imaging network, and storing a set of routing rules. A routing module executing within an operating environment provided by the router selects a route from the routing information based on destination information of a network communication and a comparison of medical imaging data of the network communication to the set of routing rules. The module parses the medical imaging data to identify a set of DICOM tags and corresponding data; and assesses the routing rules based on the DICOM tags and corresponding data.