Abstract: Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: The invention concerns a hermetic coaxial connector of the type intended to be attached to a panel to ensure hermetic coaxial traverse of said panel, comprising a central conductive contact housed with interposition of an insulator in a housing, forming an external conductor, provided with means of attachment to a panel, a sealing joint between the external conductor and the panel, and an insulating glass bead sealed to the central contact and to an annular ring housed at least partly in a recess of the housing. The ring presents a staggered configuration comprising an axial annular span connected by the glass sealing bead (7) to central contact (5), an axial span in contact with a corresponding span of the housing, a radial span supported against the corresponding span of the housing and a radial span in contact with the sealing joint (11) interposed between the ring and the panel (2).