Patents by Inventor Pierre Hugon
Pierre Hugon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5266591Abstract: The compounds are ethanolamine benzoate compounds useful for the treatment of syndrome X, and of hypertension in patients who are insulin resistant or have one or more metabolic anomalies.A compound disclosed is S-1-(m-trifluoromethylphenyl)-2-{.beta.-{4-[2-(N-(3,3-diphenylpropionyl)am ino)ethyl] benzoyloxy}ethylamino} propane.Type: GrantFiled: November 20, 1992Date of Patent: November 30, 1993Assignee: Adir et CompagnieInventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Michelle Boulanger, Francoise Lacour
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Patent number: 5266718Abstract: New ethanolamine benzoate compounds which can be used as medicaments and correspond to the formula: ##STR1## wherein R is as defined in the description, in the form of racemic compounds and enantiomers. These new compounds and their physiologically tolerable salts can be used therapeutically for treatment of insulin-resistance states.Type: GrantFiled: June 12, 1992Date of Patent: November 30, 1993Assignee: Adir et CompagnieInventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Francoise Lacour, Michelle Boulanger
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Patent number: 5079245Abstract: The compounds 2-trifluoromethyl-7-substituted-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes are disclosed and disclosed to be useful in the treatment of metabolic illnesses such as diabetes, obesity, and their complications. A perferred compound is 2-trifluoromethyl-7-amino-6,7,8,9-tetrahydro-[5H-benzocycloheptane.Type: GrantFiled: July 5, 1989Date of Patent: January 7, 1992Assignee: Adir et CompagnieInventors: Michel Wierzbicki, Pierre Hugon, Jacques Duhault, Francoise Lacour
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Patent number: 4711885Abstract: Triazole compounds of the formula: ##STR1## in which: X and X', which are the same or different, each represents hydrogen, halogen, trifluoromethyl, C.sub.1 -.sub.5 alkyl, or C.sub.1 -.sub.5 alkoxy, orX and X' together represent methylenedioxy,n is an integer of from 1 to 6,a is 0, 1 or 2;b is 0, 1, 2 or 3;c is 0, 1 or 2 andd is 2, 3, 4 or 5 such that a+b+c+d is equal to 4, 5, 6 or 7.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of pain and anxiety.Type: GrantFiled: April 1, 1986Date of Patent: December 8, 1987Assignee: Adir et CompagnieInventors: Michel Wierzbicki, Pierre Hugon, Jean-Claude Poignant
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Patent number: 4505921Abstract: New sulfonylurea compounds of the formula: ##STR1## in which n is 1 or 2,R is thienyl, furyl, pyridyl or phenyl optionally mono or disubstituted,R.sub.1 and R.sub.2, the same or different, each are hydrogen, halogen, (C.sub.1 to C.sub.5)-alkyl, (C.sub.1 to C.sub.5)-alkoxy, or trifluoromethyl, or together represent --CH.sub.2 --O--CH.sub.2 --,R.sub.3 is hydrogen, or hydroxy, andR.sub.4 is (C.sub.1 to C.sub.5)-alkyl, (C.sub.3 to C.sub.8)-cycloalkyl or azacycloalkyl of the formula: ##STR2## in which p is zero or an integer from 1 to 5, or azabicycloalkyl of the formula: ##STR3## in which m is 1, 2, or 3. These new compounds and physiologically tolerable salts thereof may be used as medicines especially in the treatment of diabetes.Type: GrantFiled: September 6, 1983Date of Patent: March 19, 1985Assignee: ADIR, S.A.R.L.Inventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 4259335Abstract: 1-methyl-4-piperidinol esters of the formula: ##STR1## in which R is 7-chloro-4-quinolyl, 7-trifluoromethyl-4-quinolyl or 8-trifluoromethyl-4-quinolyl.These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of inflammatory processes and painful syndroms.Type: GrantFiled: August 6, 1979Date of Patent: March 31, 1981Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Jacques Bure, Francoise Degrand
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Patent number: 4161529Abstract: Pyrrolidone derivatives of the formula: ##STR1## wherein R is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl,AndY is hydrogen, saturated or unsaturated hydrocarbon radical up to C.sub.4, hydroxyethyl, hydroxypropyl or carboxymethyl.These compounds are used as medicines especially in the treatment of lipid-metabolism disorders.Type: GrantFiled: February 14, 1978Date of Patent: July 17, 1979Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 4066662Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: December 30, 1976Date of Patent: January 3, 1978Assignee: Science Union et Cie., Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4064245Abstract: Phenoxy compounds of the formula: ##STR1## wherein R and R', which are the same or different, are hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, trifluoromethyl, trifluoromethylthio, trifluoromethoxy, lower alkoxy-carbonyl or dimethylsulfamoyl.These compounds are used as medicines especially in the treatment of glucid -- and lipid -- metabolism disorders.Type: GrantFiled: July 14, 1976Date of Patent: December 20, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 4048321Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: May 13, 1976Date of Patent: September 13, 1977Assignee: Science Union et CieInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4042598Abstract: Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: May 13, 1976Date of Patent: August 16, 1977Assignee: Science Union et Cie, Societe Francaise de Recherche MedicaleInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 4032658Abstract: Alkanolamine derivatives and their optical isomers of the formula: ##STR1## wherein: N IS 2 OR 3, ANDR.sub.1 and R.sub.2 are lower alkyl or taken together with the nitrogen to which they are bonded, they form pyrrolidinyl, piperidino, dimethyl piperidino, morpholino, 1-thiomorpholino, azabicyclo [3, 3, 0] octyl or azabicyclo [3, 2, 2] nonyl.These compounds are used as medicines especially in the treatment of obesity, atheroma or metabolic diseases requiring weight reduction and regulation.Type: GrantFiled: April 23, 1975Date of Patent: June 28, 1977Assignee: Science-Union et CieInventors: Laszlo Beregi, Pierre Hugon, Jacques Duhault, Michelle Boulanger
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Patent number: 3972994Abstract: Disubstituted azabicycloalkanes of the formula ##SPC1##Wherein:n is 0, 1 or 2R is saturated or unsaturated straight or branched (C.sub.1 -C.sub.5) aliphatic hydrocarbon, andX.sub.1, x.sub.2, x.sub.3, x.sub.4, x.sub.5, which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl.These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.Type: GrantFiled: November 20, 1974Date of Patent: August 3, 1976Assignee: Science Union et CieInventors: Laszlo Beregi, Pierre Hugon, Xavier Pascaud, Jean-Claude Poignant
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Patent number: 3956501Abstract: N-substituted glycinates of the formula: ##EQU1## optical isomers and acid addition salts thereof, wherein R is cyclopentyl, cyclohexyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl, methylenedioxybenzyl or trifluoromethylbenzyl.These compounds are used as medicines especially in the treatment of obesity or other metabolic diseases needing weight reduction and regulation.Type: GrantFiled: August 5, 1974Date of Patent: May 11, 1976Assignee: Science Union et Cie, Societe Francaise de Recherche MedicalInventors: Laszlo Beregi, Charles Malen, Pierre Hugon, Jacques Duhault