Patents by Inventor Pierre J. De Clercq

Pierre J. De Clercq has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin D derivatives: therapeutic applications and applications to assays of metabolities of vitamin D
    Patent number: 5093519
    Abstract: Vitamin D derivatives corresponding to the following formula I ##STR1## in which R.sub.1 denotes a substituted alkyl group having 1 to 15 carbon atoms, in particular the side chains of vitamin D.sub.2 (C.sup.20 to C.sup.28) or D.sub.3 (C.sup.20 to C.sup.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: March 3, 1992
    Assignee: Ire-Medgenix S.A.
    Inventors: Roger Bouillon, Pierre J. De Clercq, Pierre Eliard, Maurits Vandewalle
  • Method of preparing 1 .alpha.-hydroxyvitamin D and 1 .alpha.-hydroxyprevitamin D compounds, and adducts of a previtamin D or tachysterol compound with a suitable dienophile
    Patent number: 4539153
    Abstract: The invention relates to a method of preparing 1 .alpha.-hydroxyvitamin D or 1 .alpha.-hydroxy-previtamin D compounds by hydroxylating the 1 .alpha.-position of an adduct of a previtamin D compound with a suitable dienophile, in which adduct optionally present hydroxy group or hydroxy groups is or are protected, if desired, and after removal of the protecting group or groups, isolating the 1 .alpha.-hydroxyvitamin D or 1 .alpha.-hydroxy-previtamin D compound.The invention also relates to 1 .alpha.-hydroxy-previtamin D compounds.The invention further relates to an adduct of a previtamin D or tachysterol compound with a dienophile of the general formula ##STR1## in which A' and B' are equal and represent methoxy groups or ethoxy groups, or in which A' and B' together constitute a phenylimino or o-phenylene group.
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: September 3, 1985
    Assignee: Duphar International Research B.V.
    Inventors: Maurits Vandewalle, Luc J. Vanmaele, Pierre J. De Clercq, Sebastianus J. Halkes, Wilhelmus R. M. Overbeek