Patents by Inventor Pierre Labrude

Pierre Labrude has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macromolecular conjugates of hemoglobin, a procedure for their preparation and their uses
    Patent number: 5079337
    Abstract: The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constitutedon the one hand, by hemoglobin,on the other, by a water-soluble polymer P containing polar groups, this macromolecular conjugate contains Z sites, bound to the polymer P and containing at least one negative charge carried for example by sulfate groups, the polymer P being bound to hemoglobinon the one hand, through the intermediary of at least one linkage established between at least one of the Z sites contained in the polymer and hemoglobin,and, on the other, through the intermediary of at least one covalent linkage established between the polymer and hemoglobin, or between at least one of the Z sites contained in the polymer and hemoglobin.The macromolecular conjugates according to the invention exhibit a lower affinity for oxygen than that of free hemoglobin.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: January 7, 1992
    Assignee: Pasteur Merieux Serums et Vaccins S.A.
    Inventors: Michele Leonard, Edith Dellacherie, Jean M. L. Neel, Claude Vigneron, Pierre Labrude