Abstract: A bone regeneration membrane comprising: a dense layer made of resorbable polymer, said dense layer having first and second opposite surfaces and being adapted to form a barrier to cells and soft tissues, a nanofibrillar layer made of resorbable polymer and attached to the first surface of the dense layer, said nanofibrillar layer comprising fibers having a diameter of nanometer size, said fibers being interlaced so as to present an average pore size greater than 10 ?m to allow cell permeability and bone tissue regeneration, the nanofibrillar layer having a permeability ? between 0.4*10-9 m2 and 11*10-9 m2, preferably between 1*10-9 m2 and 4*10-9 m2, in particular substantially of 2*10-9 m2.

Abstract: A bone regeneration membrane comprising: a dense layer made of resorbable polymer, said dense layer having first and second opposite surfaces and being adapted to form a barrier to cells and soft tissues, a nanofibrillar layer made of resorbable polymer and attached to the first surface of the dense layer, said nanofibrillar layer comprising fibers having a diameter of nanometer size, said fibers being interlaced so as to present an average pore size greater than 10 ?m to allow cell permeability and bone tissue regeneration, the nanofibrillar layer having a permeability ? between 0.4*10-9 m2 and 11*10-9 m2, preferably between 1*10-9 m2 and 4*10-9 m2, in particular substantially of 2*10-9 m2.

Abstract: A method for forming nanofiber web comprises the steps of: mixing (21) polymeric material with a solvent to obtain a liquid mixture having a viscosity above a predetermined shear viscosity value at room temperature; feeding (23) a spray nozzle with said mixture; projecting (25) said mixture through said nozzle with a gas jet, wherein the projected polymeric material solidifies and forms nanofibers; depositing (27) said nanofibers on a collecting surface to form said nanofiber web.

Abstract: The invention relates to the field of medical devices. More in particular, the invention relates to a method for coating by depositing inorganic ions and a bioactive agent to provide sterile medical devices, wherein said coating improves the biocompatibility and/or bioactivity of a medical device, such as an orthopedic or dental prosthesis. Furthermore, the invention relates to a medical device coated with a method according to the invention and to a reactor for use in a method according to the invention.

Abstract: The invention relates to a bone filler comprising calcium salt particles, an organic binder having an affinity for calcium phosphate, cells chosen from the group of stem cells, osteogenic cells, and osteoprogenitor cells, and a pharmaceutically acceptable buffer. A great advantage of a bone filler, according to the invention, is that it is an injectable formulation that allows for its introduction in an osseous defect through the needle of a syringe.

Abstract: The invention is directed to a method of preparing porous metals, as well as to these porous metals per se. More in particular the invention is directed to the use of these porous metals in the preparation of medical items, such as implants. The invention further relates to a method of providing a porous metal coating on a substrate, in particular on the surface of a medical item, such as an implant or scaffold for tissue engineering. According to the method of the invention, a polymeric foam is impregnated with a slurry of metal particles, such as titanium, tantalum, titanium alloy or tantalum alloy particles. The impregnated foam is subsequently dried and subjected to pyrolysis and subsequent sintering. Due to the presence of metal hydrides, the formation of undesired compounds, such as metal oxides or nitrides, is avoided.

Abstract: A tricalcium-phosphate-based prosthetic material is disclosed, which is a sintered ceramic body mainly consisting of tricalcium phosphate containing a limited amount of zinc, which is a known element having an osteogenesis-promoting effect, in the form of a solid solution. By virtue of the limited content of zinc and the form of solid solution in which zinc is contained, the inventive material exhibits an osteogenesis-promoting effect without toxicity. The ceramic body is prepared, preferably, by a process in which a tricalcium phosphate powder containing 0.015-8.00% by weight of zinc is diluted by the addition of hydroxyapatite and/or tricalcium phosphate free from zinc in such a proportion as to give a (Ca+Zn)/P molar ratio of 1.55 to 1.65 and the powder blend is shaped and subjected to sintering.