Abstract: Water soluble agents effective as immunological adjuvants for stimulating in the host the immune response to various antigens, comprising an acyl-muramic acid group, wherein acyl means acetyl or glycolyl, and a short peptide chain linked to said acyl-muramic acid group, the first and second amino acids of said peptide chain being preferentially alanine and glutamic acid respectively.

Abstract: The adjuvant is 2-(p-amino-phenyl-2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L- alanyl-D-isoglutamine, which compound in its .beta. glucoside form, corresponds with the formula ##STR1## It is notably useful for favoring immunitory responses relative to antigens of low immunogenicity.

Abstract: The invention pertains to drug oil-free compositions, notably aqueous injectable compositions acting as non-specific adjuvants to stimulate in a host the immune responses to different antigens. The active principle of these oil-free compositions is N-acetyl-muramyl-L-alanyl-D-glutamic acid.

Abstract: The invention pertains to drug oil-free compositions, notably aqueous injectable compositions acting as non-specific adjuvants to stimulate in a host the immunitary responses to different antigens. The active principle of these oil-free compositions is N-acetyl-muramyl-L-alanyl-D-isoglutamine.

Abstract: The invention relates to new water-soluble agents which are effective as immunizing adjuvants. These adjuvant agents are the methyl, ethyl or propyl esters of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-isoglu tamine and of 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-glutam ic acid, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-alanyl-D-(.alph a.-methylamide)-glutamic and 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-isoglut amine, the 2-(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-D-propionyl-L-seryl-D-glutami c acid and their derivatives. They are particularly useful to prepare adjuvant medicinal compositions, used for increasing the efficiency of vaccines.

Abstract: The invention relates to novel derivatives of L-phenylalanine and particularly to tosyl-paraguanidino-L-phenylalanine methyl ester, to ter-butyloxycarbonyl derivative of para-guanidino-L-phenylalanine and to para-guanidino-L-phenylalanine.The tosyl-paraguanidino-L-phenylalanine methyl ester is an efficient trypsine substrate.

Abstract: Process for the preparation of the compound consisting of the peptide chain: leucyl -- seryl -- arginyl -- leucyl -- phenylalanyl -- aspartyl -- asparaginyl -- alanine (I), characterized in that the synthesis is carried out from constituent amino-acids of the peptide chain (I), or from peptide elements resulting from the condensation of two or several of these basic amino-acids, and by the condensation of these amino-acids or peptide elements, in a succession of steps so that the basic amino-acids occur in the final peptide chain in the order indicated in (I).

Abstract: The invention relates to N-acetylmuramyl-D-alanyl-D-isoglutamine and to N-acetylmuramyl-L-alanyl-L-isoglutamine which possess immunosuppressive or immunodepressive properties, as well as to the pharmaceutical compositions containing one of said compounds in association with a pharmaceutical vehicle.