Abstract: It is provided a method for stimulating the secretion of specialized pro-resolving mediators in a subject after the administration of a therapeutic phospholipid compositions such as CaPre®, wherein the composition also increases plasma levels of 17S-HDHA, PDX and 18RS-HEPE in the subject. Increased levels of protectins and resolvins are useful in protecting against many inflammatory-related diseases.

Abstract: An apparatus for metering and dispensing a predetermined amount of a viscous substance includes an inlet fluidly connected to a supply flow path that branches into a metering flow path and a first dispensing flow path which branches into a second dispensing flow path that is angled relative to the first dispensing flow path. The apparatus also includes a supply valve disposed in the supply flow path, a dispensing valve disposed in the first dispensing flow path and the second dispensing flow path, a metering piston disposed in the metering flow path, and a dispensing piston. A method of metering and dispensing a volume of a viscous substance is also provided.

Abstract: It is provided processes for generating a therapeutic concentrated phospholipid composition from raw krill oil containing high content of free fatty acids. Particularly it is provided a process producing a concentrated phospholipid composition comprising the steps of: fractionating a raw hill oil (RKO) containing at least 7% of free fatty acids (FFA) obtaining a fraction enriched in phospholipids and an undesired layer; and separating said fraction enriched in phospholipids from the undesired layer, producing the therapeutic concentrated phospholipid composition with a yield of at least 30%.

Abstract: An apparatus for metering and dispensing a predetermined amount of a viscous substance includes an inlet fluidly connected to a supply flow path that branches into a metering flow path and a first dispensing flow path which branches into a second dispensing flow path that is angled relative to the first dispensing flow path. The apparatus also includes a supply valve disposed in the supply flow path, a dispensing valve disposed in the first dispensing flow path and the second dispensing flow path, a metering piston disposed in the metering flow path, and a dispensing piston. A method of metering and dispensing a volume of a viscous substance is also provided.

Abstract: It is provided a process for generating enriched phospholipid compositions from raw krill oil, where such processes may be batchwise, continuous, of include both batchwise steps and continuous steps. The present technology provides high quality enriched phospholipid compositions from such methods. Moreover, the continuous process provides a significantly higher throughput compared to a batch process while concurrently providing products of equal or greater quality.

Abstract: The present invention relates to a malleable protein matrix (MPM), which is the reaction product of the agglomeration of proteins after a fermentation process and is exhibiting biological activities and is suitable for the incorporation (or encapsulation) of various hydrophilic or lipophylic substances. The present invention also relates to the process for the preparation of the malleable protein matrix and its usages.

Abstract: In accordance with the present invention, there is provided a probiotic composition comprising an effective amount of Lactobacillus kefiranofaciens in association with a suitable carrier. The probiotic composition has many probiotic effects such as intestinal adherence, intestinal persistence, positive modulation of the intestinal microflora, protection against intestinal pathogens, immunomodulation, protection against systemic inflammation, protection against intestinal inflammation, protection against allergies, protection against diarrhea, protection against diabetes, protection against hyperlipidemia and protection against colon cancer. In accordance with the present invention, there is also provided a method of treatment and/or prevention of a number of diseases for which the composition has a beneficial effect.

Abstract: It is disclosed a method of modulating a peroxisome proliferator activated receptor (PPAR) activity in a patient comprising administering to said subject an effective amount of a malleable protein matrix (MPM), uses thereof and pharmaceutical compositions comprising MPM for treating obesity related disorders and their associated metabolic impact by modulating PPAR activity.

Abstract: The present invention relates to a delivery system for delivery of an active molecule to a patient, the delivery system comprising a population of exopolysaccharide micelles, each micelle defining a core for containing the active molecule.

Abstract: It is disclosed a method of immunomodulating an immune response in a subject comprising administering to a subject a malleable protein matrix (MPM), from fermented whey, in an amount effective to modulate the biological activity of Th17 cells, and its associated metabolic pathway, for a preventative or a therapeutic purpose of a variety of health applications in the field of immunity or obesity related diseases.

Abstract: The present invention relates to an anti-cancer vaccine composition comprising an antigen in association with an effective amount of at least one immunomodulator chemotherapeutic adjuvant eliciting an immune response in a patient and a pharmaceutically acceptable carrier. It also relates to method of preventing tumor growth and reducing tumor growth using the anti-cancer vaccine composition of the present invention.

Abstract: In a class of embodiments, a method for controlling playback of a video program by a media player including by providing visual feedback (referred to as a thumbnail) indicative of content of the program at a target location, a media player configured to perform any embodiment of the method, and a computer readable medium which stores code for implementing any embodiment of the method. Preferably at least one thumbnail is displayed and updated in real-time during playback of the program. Typically each thumbnail is a compressed or reduced-scale version of a frame of the program at, or a representative image of a segment of the program including, the target location.

Abstract: In accordance with the present invention, there is provided a probiotic composition comprising an effective amount of Lactobacillus kefiranofaciens in association with a suitable carrier. The probiotic composition has many probiotic effects such as intestinal adherence, intestinal persistence, positive modulation of the intestinal microflora, protection against intestinal pathogens, immunomodulation, protection against systemic inflammation, protection against intestinal inflammation, protection against allergies, protection against diarrhea, protection against diabetes, protection against hyperlipidemia and protection against colon cancer. In accordance with the present invention, there is also provided a method of treatment and/or prevention of a number of diseases for which the composition has a beneficial effect.

Abstract: Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particular, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.

Abstract: The present invention relates to a malleable protein matrice (MPM), which is the reaction product of the agglomeration of proteins after a fermentation process and is exhibiting biological activities and is suitable for the incorporation (or encapsulation) of various hydrophilic or lipophylic substances. The present invention also relates to the process for the preparation of the malleable protein matrice and its usages.

Abstract: The present invention relates to an anti-cancer vaccine composition comprising an antigen in association with an effective amount of at least one immunomodulator chemotherapeutic adjuvant eliciting an immune response in a patient and a pharmaceutically acceptable carrier. It also relates to method of preventing tumor growth and reducing tumor growth using the anti-cancer vaccine composition of the present invention.

Abstract: Compositions comprising non-ionic block copolymers are useful for the treatment of autoimmune, inflammatory and proliferative diseases and for reducing graft/implantation rejection. The present invention also relates to methods of treating animals having various autoimmune, inflammatory and proliferative diseases. The present invention also relates to methods of reducing inflammation in an animal comprising administering the compositions of the invention. Also, the present invention relates to methods of reducing autoimmune responses and to methods of reducing graft/implantation rejection comprising administering the compositions of the inventions. A typical embodiment is a mixture of Pluronics F127 and L61.

Abstract: The present invention is directed to polynucleotide compositions containing (a) a polynucleotide or derivative thereof and (b) a block copolymer having a polyether segment and a polyanion segment, compositions containing (a) a polynucleotide or its derivative thereof, (b) at least one polyanionic polymer, and (c) at least one amphiphilic block copolymer, and methods of using these compositions for gene therapy.

Abstract: Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particular, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.

Abstract: The present invention relates to access control systems ore commonly referred to as security systems. In a preferred embodiment of the invention, the access control system uses a memory card and a network of access control subsystems. Among the specific characteristics of the invention are the loading of schedule data on the memory card and the devolution of specific functions such as schedule validation to the access control subsystem level. These characteristics of the system provide, among other advantages, a reduction of the amount of wiring, a reduction in the hardware and installation costs, a considerable memory saving for the hardware and an increase in the system's capacity and flexibility.