Patents by Inventor Pierre Mourad

Pierre Mourad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150151142
    Abstract: Methods and systems for transcranial ultrasound neuromodulation as well as targeting such neuromodulation in the brain are disclosed. Automated transcranial Doppler imaging (aTCD) of blood flow in the brain is performed and one or more 3-dimensional maps of the neurovasculature are generated. Ultrasound energy is delivered transcranially in conjunction to induce neuromodulation. One or more brain regions for neuromodulation are targeted by using brain blood vessel landmarks identified by aTCD components. The landmarks are used for initial targeting of the neuromodulation to one or more brain regions of interest and/or for maintaining neuromodulation targeting despite user or device movements. Acoustic contrast agents may be employed to generate broadband ultrasound waves locally at the site of target cells.
    Type: Application
    Filed: September 30, 2014
    Publication date: June 4, 2015
    Inventors: William J. TYLER, Pierre MOURAD, Daniel Z. WETMORE
  • Publication number: 20140039279
    Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Inventors: Jeffrey G. Jarvik, Pierre Mourad, Michel Kliot, Robert C.A. Frederickson, Abbi M McClintic, Trevor C. Dickey, Michael Gofeld
  • Publication number: 20070016031
    Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.
    Type: Application
    Filed: March 31, 2006
    Publication date: January 18, 2007
    Inventors: Pierre Mourad, Michel Kliot, Rex Patterson, Alec Rooke
  • Publication number: 20060191086
    Abstract: A power toothbrush (10) is disclosed having a handle (15), battery (12), ultrasonic drive circuit (14), motor (16), control unit (18), and toothbrush head (20). The toothbrush head includes bristles (26) and a waveguide (24) that is operatively connected to an ultrasonic transducer (22). The waveguide facilitates the transmission of acoustic energy into the dental fluid to achieve improved cleaning and stain removal and improved cleaning in interproximal and subgingival regions. In one embodiment an ultrasound transducer module (30) includes a plurality of piezoelectric elements (32, 34) that may be mechanically connected in series, and electrically connected in parallel. One or more contacts (36) connect the elements, and a waveguide structure (50). An impedance matching layer (38) may be provided between the waveguide and the ultrasonic transducer module. The waveguide may be formed from an relatively soft material, for example, a polymer having a hardness between 10 and 65 Shore A.
    Type: Application
    Filed: May 3, 2006
    Publication date: August 31, 2006
    Inventors: Pierre Mourad, James McInnes, George Barrett, David Ballard, Gerald Brewer, Frederick Bennett
  • Publication number: 20060100530
    Abstract: Methods and systems for long term monitoring of one or more physiological parameters such as respiration, heart rate, body temperature, electrical heart activity, blood oxygenation, blood flow velocity, blood pressure, intracranial pressure, the presence of emboli in the blood stream and electrical brain activity are provided. Data is acquired non-invasively using ambulatory data acquisition techniques.
    Type: Application
    Filed: September 26, 2005
    Publication date: May 11, 2006
    Applicants: Allez PhysiOnix Limited, University of Washington
    Inventors: Michel Kliot, Robert Frederickson, Kamran Forghani, Pierre Mourad
  • Publication number: 20060079773
    Abstract: Systems and methods for assessing a physiological parameter of a target tissue wherein a pulse of focused ultrasound is applied to a target tissue site thereby inducing oscillation of the target tissue. By these systems and methods, a property of an acoustic signal emitted from the oscillating target tissue is measured and related to a physiological property of the tissue. Specific applications for systems and methods of the present invention include the assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.
    Type: Application
    Filed: February 4, 2005
    Publication date: April 13, 2006
    Inventors: Pierre Mourad, Michel Kliot, Robert Frederickson
  • Publication number: 20050136102
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: May 28, 2004
    Publication date: June 23, 2005
    Inventors: Allan Hoffman, Patrick Stayton, Oliver Press, Niren Murthy, Chantal Reed, Lawrence Crum, Pierre Mourad, Tyrone Porter
  • Publication number: 20050091770
    Abstract: A power toothbrush (10) is disclosed having a handle (15) containing a rechargeable battery (12), an ultrasonic drive circuit (14), a sonic component (16) such as a motor, and a control unit (18). The handle is connected to a toothbrush head (20) preferably having a plurality of bristles (26) and an ultrasonic transducer (22) that is operatively connected to a waveguide (24) that extends from the toothbrush head generally adjacent the bristles. The waveguide facilitates the transmission of acoustic energy into the dental fluid. It is contemplated that the waveguide may be utilized in manual or power toothbrushes, and in a combination without the sonic component, or in a combination without the ultrasonic transducer. Toothbrushes disclosed herein achieve improved plaque and stain removal from the teeth as well as interproximal and subgingival regions, while enhancing the user experience, massaging the gums, and stimulating dental tissue.
    Type: Application
    Filed: November 3, 2004
    Publication date: May 5, 2005
    Inventors: Pierre Mourad, Francis Olson, Roger Thompson, Jason Seawall
  • Publication number: 20050015009
    Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship.
    Type: Application
    Filed: June 3, 2004
    Publication date: January 20, 2005
    Inventors: Pierre Mourad, Brandt Mohr, Michel Kliot, Robert Frederickson, R. Thompson, Jason Seawall