Abstract: The present invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, for use in the treatment of Hereditary Hemorrhagic Telangiectasia (HHT).

Abstract: The invention relates to a method for the construction and sustainable management of a hybrid turf sports ground, with management of a shallow water table in the structure of the sports ground, which comprises: a first step of constructing a structure (S) placed on a base (F), the structure comprising N stacked porous layers (Ci); a second step of installing turf on the surface of the top layer (Ci), the installation of the turf possibly being carried out by sowing; and, of the N layers, one hybrid layer (H) is constituted either (i) by a cultivation substrate that comprises synthetic reinforcing elements, or (ii) by a cultivation substrate that shares the space of the hybrid layer (H) with synthetic reinforcing elements.

Abstract: Laser diode thermal desorption coupled with tandem mass spectrometry systems and methods are described to detect at least one target analyte in a sample by negative ion mode mass spectrometry. For instance, the system and method involve desorbing a sample prepared for mass spectrometry analysis by laser diode thermal desorption to obtain a desorbed sample, and then ionizing the desorbed sample under conditions to generate an ionized analyte flow comprising a superoxide radical anion (O2.?) adduct detectable by negative ion mode mass spectrometry; and then detecting the O2.? adduct by negative ion mode mass spectrometry, to thereby detect the target analyte.

Abstract: A mass spectrometer having a triple ionization interface for ionizing sample components is provided. The ionization interface of the mass spectrometer includes a means for ionizing sample components via electrostatic ionization, atmospheric pressure chemical ionization, and laser diode thermal desorption.

Abstract: A mass spectrometer having a triple ionization interface for ionizing sample components is provided. The ionization interface of the mass spectrometer includes a means for ionizing sample components via electrostatic ionization, atmospheric pressure chemical ionization, and laser diode thermal desorption.

Abstract: A local coordinate system in which the turfed area is digitized, and a marking area is divided into elementary cells to form a matrix, and the pattern to be marked is broken down into a mosaic of pixels associated with the elementary cells of the matrix. Next, for each elementary cell of the matrix, tasks to be performed by the marking devices are determined according to a value of the pixel associated with said elementary cell, to mark the pattern to be marked on the marking area; and the movement of the vehicle over the turfed area is controlled so as to cover all of the elementary cells, and the marking devices are controlled so as to perform the tasks to be performed in each elementary cell.

Abstract: A method for detecting boar taint in a fat sample is provided. The method includes extracting boar taint compounds from the fat sample to obtain a boar taint extract which includes indole components and androstenone. The method also includes derivatizing the indole components such that the derivatized indole components have a lower volatility than the indole components. The method also includes desorbing the derivatized indole components and the androstenone by Laser Diode Thermal Desorption (LDTD), and ionizing the desorbed analytes. The content of boar taint compounds in the fat sample can then be determined by subjecting the ionized analytes to mass spectrometry.

Abstract: A culture support substrate comprising: a first part, making up the backbone of the substrate and representing more than 70% of the total volume of the substrate, composed of particles P>100 ?m with particle size greater than 100 ?m, the particles as a whole consisting of hard particles PH>100 and/or of resilient particles PR>100, wherein the resilient particles make up a proportion by volume PV of between 0% and 100% by volume of this first part; a second part of corpuscular components P<100 with a particle size of less than 100 ?m, and making up from 0 to 450 g/l of the substrate; a third part, making up from 0 to 200 g/l of the substrate, composed of fine fibers between 3 mm and 100 mm in length and between 5 ?m and 35 ?m in diameter; and a fourth part, making up from 0 to 200 g/l of the substrate.

Abstract: A culture support substrate comprising: a first part, making up the backbone of the substrate and representing more than 70% of the total volume of the substrate, composed of particles P>100 ?m with particle size greater than 100 ?m, the particles as a whole consisting of hard particles PH>100 and/or of resilient particles PR>100, wherein the resilient particles make up a proportion by volume PV of between 0% and 100% by volume of this first part; a second part of corpuscular components P<100 with a particle size of less than 100 ?m, and making up from 0 to 450 g/l of the substrate; a third part, making up from 0 to 200 g/l of the substrate, composed of fine fibres between 3 mm and 100 mm in length and between 5 ?m and 35 ?m in diameter; and a fourth part, making up from 0 to 200 g/l of the substrate.

Abstract: A culture support substrate comprising: a first part, making up the backbone of the substrate and representing more than 70% of the total volume of the substrate, composed of particles P>100 ?m with particle size greater than 100 ?m, the particles as a whole consisting of hard particles PH>100 and/or of resilient particles PR>100, wherein the resilient particles make up a proportion by volume PV of between 0% and 100% by volume of this first part; a second part of corpuscular components P<100 with a particle size of less than 100 ?m, and making up from 0 to 450 g/l of the substrate; a third part, making up from 0 to 200 g/l of the substrate, composed of fine fibers between 3 mm and 100 mm in length and between 5 ?m and 35 ?m in diameter; and a fourth part, making up from 0 to 200 g/l of the substrate.

Abstract: Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.

Abstract: Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.

Abstract: A culture support substrate comprising: a first part, making up the backbone of the substrate and representing more than 70% of the total volume of the substrate, composed of particles P>100 ?m with particle size greater than 100 ?m, the particles as a whole consisting of hard particles PH>100 and/or of resilient particles PR>100, wherein the resilient particles make up a proportion by volume PV of between 0% and 100% by volume of this first part; a second part of corpuscular components P<100 with a particle size of less than 100 ?m, and making up from 0 to 450 g/l of the substrate; a third part, making up from 0 to 200 g/l of the substrate, composed of fine fibres between 3 mm and 100 mm in length and between 5 ?m and 35 ?m in diameter; and a fourth part, making up from 0 to 200 g/l of the substrate.

Abstract: An apparatus and method for regenerating ion samples for a mass spectrometer are provided. Source samples are loaded on a support which is heated by a laser beam, desorbing the sample without ionization. The desorbed sample is carried by a carrier gas flow through a transfer tube, at the output of which it is ionized by corona discharge or photo-ionization. The obtained ionized sample may be analyzed in a mass spectrometer or used to serve any other appropriate purpose.

Abstract: A wood heat-treating method, a plant for carrying out the method, and the heat-treated wood. The heat-treating method consists in bringing each wood piece of a treatable lot into contact with a temperature controlled conductive press, whose temperature is accurately controllable in time and in intensity. The pieces are heated to or held at a desired temperature by any heat control for treatment and the wood is conductively heated to maintain the temperature and to cool the wood.

Abstract: An apparatus and method for regenerating ion samples for a mass spectrometer are provided. Source samples are loaded on a support which is heated by a laser beam, desorbing the sample without ionization. The desorbed sample is carried by a carrier gas flow through a transfer tube, at the output of which it is ionized by corona discharge or photo-ionization. The obtained ionized sample may be analyzed in a mass spectrometer or used to serve any other appropriate purpose.

Abstract: An apparatus and method for regenerating ion samples for a mass spectrometer are provided. Source samples are loaded on a support which is heated by a laser beam, desorbing the sample without ionization. The desorbed sample is carried by a carrier gas flow through a transfer tube, at the output of which it is ionized by corona discharge or photo-ionization. The obtained ionized sample may be analyzed in a mass spectrometer or used to serve any other appropriate purpose.

Abstract: A complex includes: (1) a probe containing a heteropolymeric probe sequence of nucleic acids or nucleic acid analogues; and (2) a target containing a heteropolymeric target sequence of nucleic acids or nucleic acid analogues, wherein: (a) at least one of the probe and the target is purified or synthetic; and (b) the heteropolymeric probe sequence is bonded to the heteropolymeric target sequence by Watson-Crick complementary base interaction or by homologous base interaction, provided that when the complex is a duplex and the heteropolymeric probe sequence is antiparallel to the heteropolymeric target sequence, the heteropolymeric probe sequence is bonded to the heteropolymeric target sequence by homologous base interaction, and provided that when the complex is a triplex, the complex is free of recombination proteins. A method for assaying a target includes detecting formation of the complex.

Abstract: A method for homogeneously assaying biopolymer bonding includes obtaining signals from a test sample before, during and/or after the application of stimulus to the test sample and correlating the signals. The signals, whose magnitude correlate with binding affinity, can be, for example, electrical conductance and/or fluorescent intensity. The stimulus can be, for example, electric voltage and/or laser radiation. Preferably, different types of signals are measured and compared so as to enhance the reliability of the assay.

Abstract: A purification method includes bonding a probe to a target in a sample to form a complex, and separating the sample from the complex to separate in a sequence specific manner the target from the sample. The complex, which is immobilized on a support, is a duplex, triplex or quadruplex formed by Watson-Crick complementary base interaction or by homologous base interaction, provided that when the complex is a duplex and the heteropolymeric probe sequence is antiparallel to the heteropolymeric target sequence, the heteropolymeric probe sequence is bonded to the heteropolymeric target sequence by homologous base interaction, and provided that when the complex is a triplex, the complex is free of recombination proteins. A kit for performing the method includes the support and the probe.