Abstract: A coupling is connectable to an access of a blood compartment. The compartment has at least one inner surface intended to be coated with at least one molecular layer of a substance soluble in an aqueous solution and capable of increasing biocompatibility. A determined quantity of the substance is deposited inside the coupling in a form such that the substance is capable of undergoing, substantially without deterioration, an irradiation capable of sterilizing the coupling.

Abstract: A method for preventing activation of the contact phase of blood or plasma which comes into contact with a semi-permeable membrane based on polyacrylonitrile bearing fixed negative charges, which is fitted in apparatus for the treatment of blood or plasma, by extra-corporal circulation, said method comprising contacting blood or plasma with said semi-permeable membrane, wherein: a neutral or cationic polymer is combined with said semi-permeable membrane before or after formation of the membrane, and before sterilization of the membrane; the overall ionic capacity of the semi-permeable membrane, based on polyacrylonitrile bearing fixed negative charges and containing a neutral or cationic polymer, is negative; the overall ionic capacity of the semi-permeable membrane, based on polyacrylonitrile bearing fixed negative charges and containing a neutral or cationic polymer, is, as an absolute value, not more than 10% less than the overall ionic capacity of the same semi-permeable membrane without a neutral or cati

Abstract: A medical apparatus for the extracorporeal treatment of blood or plasma comprises a semi-permeable membrane consisting of at least one electronegative polymer, such that the surface of the semi-permeable membrane has negative electric charges. Before the sterilization of the apparatus, and before or after the formation of the membrane, at least one cationic and anti-protease agent is incorporated in at least one part of the membrane, this agent undergoing bulk adsorption or semi-bulk adsorption in the membrane and/or being bound by an ionic interaction with the electronegative sites of the membrane.

Abstract: The invention relates to the use of a neutral or cationic polymer for preventing activation of the contact phase of blood or plasma which comes into contact with a semi-permeable membrane based on polyacrylonitrile bearing fixed negative charges, which is fitted in apparatus for the treatment of blood or plasma by extra-corporal circulation, by combination of the neutral or cationic polymer, before or after formation of the membrane and before its sterilization, so as to modify the electrical properties of the membrane, the Zeta potential “Z” and the electrical resistivity “R” in order to obtain: either an electrokinetic index “I” of less than or equal to 0.8, “I” corresponding to Log10 (|Z|/R), or a positive Zeta potential “Z” of between 0 and 15 mV (limits not included).

Abstract: An apparatus for the treatment of blood or plasma by extracorporeal circulation includes a compartment for the circulation of blood. The compartment is provided with two accesses and has at least one inner surface intended to be coated, after sterilization, with at least one molecular layer of a substance soluble in an aqueous solution. The aqueous solution is capable of increasing the bicompatibility of the inner surface of the compartment. A determined quantity of the substance is deposited inside the blood compartment, at one of the accesses, in a form such that the substance is capable of undergoing, substantially without deterioration, an irradiation capable of sterilizing the apparatus.