Patents by Inventor Pierre VANTOUROUT

Pierre VANTOUROUT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240131191
    Abstract: The invention features compositions and methods useful in treating inflammation of the gut, such as inflammation associated with inflammatory bowel disease, by modulating ?? T cells (e.g., V?4+ cells). Particular embodiments include V?4+ cells expressing heterologous protein; polynucleotides containing genes contributing to functional expression of BTNL3, BTNL8, and HNF4A; methods of treating a subject using V?4+ cells or gene therapy; and methods of identifying a subject having imitations associated with inflammation of the gut. Compositions and methods of the invention can be used in the treatment of inflammation and cancer of the gut.
    Type: Application
    Filed: August 11, 2023
    Publication date: April 25, 2024
    Applicant: KING'S COLLEGE LONDON
    Inventors: Adrian HAYDAY, Robin DART, Natalie PRESCOTT, Pierre VANTOUROUT, Iva ZLATAREVA
  • Publication number: 20240123090
    Abstract: The invention features compositions and methods useful in treating inflammation of the gut, such as inflammation associated with inflammatory bowel disease, by modulating ?? T cells (e.g., V?4+ cells). Particular embodiments include V?4+ cells expressing heterologous protein; polynucleotides containing genes contributing to functional expression of BTNL3, BTNL8, and HNF4A; methods of treating a subject using V?4+ cells or gene therapy; and methods of identifying a subject having imitations associated with inflammation of the gut. Compositions and methods of the invention can be used in the treatment of inflammation and cancer of the gut.
    Type: Application
    Filed: August 11, 2023
    Publication date: April 18, 2024
    Applicant: KING'S COLLEGE LONDON
    Inventors: Adrian HAYDAY, Robin DART, Natalie PRESCOTT, Pierre VANTOUROUT, Iva ZLATAREVA
  • Publication number: 20230159638
    Abstract: The invention relates to ex vivo methods of modulating gamma variable 4 (V?4) T cells using antibodies or fragments thereof, which specifically bind to a V?4 chain of a ?? T cell receptor (TCR) and not to a gamma variable 2 (V?2) chain of a ?? TCR. Methods of treatment and other uses of expanded populations of V?4 T cells produced by said methods are also provided.
    Type: Application
    Filed: February 24, 2021
    Publication date: May 25, 2023
    Applicant: GAMMADELTA THERAPEUTICS LIMITED
    Inventors: Oliver NUSSBAUMER, Oxana POLYAKOVA, Adrian HAYDAY, Pierre VANTOUROUT
  • Publication number: 20230090901
    Abstract: An isolated antibody or fragment thereof, which specifically binds to a gamma variable 4 (V?4) chain of a ?? T cell receptor (TCR) and not to a gamma variable 2 (V?2) chain of a ?? TCR is provided herein. Methods of treatment and other uses of said antibodies are also provided along with methods of producing said antibodies.
    Type: Application
    Filed: February 24, 2021
    Publication date: March 23, 2023
    Applicant: GammaDelta Therapeutics Limited
    Inventors: Oxana Polyakova, Oliver Nussbaumer, Adrian Hayday, Pierre Vantourout
  • Publication number: 20210246187
    Abstract: Protein constructs comprising a BTNL3/8 targeting moiety, a payload and an optional linker are described herein. Pharmaceutical compositions comprising the constructs, and methods of use thereof are presented.
    Type: Application
    Filed: June 5, 2019
    Publication date: August 12, 2021
    Inventors: Oliver NUSSBAUMER, Oxana POLYAKOVA, Raj MEHTA, Adrian HAYDAY, Pierre VANTOUROUT, Iva ZLATAREVA, Daisy MELANDRI, Robin John Campbell DART, Adam LAING
  • Publication number: 20200297871
    Abstract: The invention features compositions and methods useful in treating inflammation of the gut, such as inflammation associated with inflammatory bowel disease, by modulating ?? T cells (e.g., V?4+ cells). Particular embodiments include V?4+ cells expressing heterologous protein; polynucleotides containing genes contributing to functional expression of BTNL3, BTNL8, and HNF4A; methods of treating a subject using V?4+ cells or gene therapy; and methods of identifying a subject having mutations associated with inflammation of the gut. Compositions and methods of the invention can be used in the treatment of inflammation and cancer of the gut.
    Type: Application
    Filed: September 17, 2018
    Publication date: September 24, 2020
    Inventors: Adrian HAYDAY, Robin John Campbell DART, Natalie PRESCOTT, Pierre VANTOUROUT, Iva ZLATAREVA