Abstract: Device for recirculating shower water: a mixing device is connected directly to the hot and cold water inlets, the cold water inlet is connected to a recirculation system; a pump is actuated while the cold water inlet is cut off. In such a device, the hot water flow rate is kept by the mixing device just high enough to compensate for the thermal losses of the water circulating through the system. Water losses are thus minimized to the strict requirement. Advantage: partial continual renewal of the shower water, unlike systems involving full recirculation.

Abstract: Transfecting compounds which include an aminoglycoside linked to a lipid via a spacer, and their polyguanidylated derivatives are provided. These compounds are useful for the in vitro, ex vivo, or in vivo transfection of nucleic acids into various cell types.

Abstract: The present invention relates to a composition comprising a siRNA and a transfecting compound consisting of an aminoglycoside of the class of 4,5-disubstituted 2-deoxystreptamine ring linked via a spacer molecule to a lipid moiety of formula —(R1)R2 wherein R1 and R2 represent, independently of one another, a hydrogen atom or a fatty aliphatic chain or R1 or R2 is absent, with the proviso that at least one of R1 and R2 represents a fatty aliphatic chain; or —OR3 or —NR3 wherein R3 represents a steroidal derivative. The invention also concerns in vitro and in vivo applications of these compositions.

Abstract: The invention concerns the use of aromatic compounds capable of binding with G-quadruplex structures to produce medicines with anti-telomerase effect. Said compounds correspond to formula (I) wherein: R1, R2 and R3, identical or different, represent a hydrogen atom, or a —CH2—NH—(CH2)n—X group, wherein n is an integer from 2 to 4, and X is selected among —NH2—, —N(CH3)2 radicals, a heterocyclic radical such as piperidyl, imidazolyl, morpholinyl radical, or an indole-type condensed heterocyclic radical, —Z represents CH or N, each compound comprising two nitrogen atoms in the Z positions. The invention is useful for producing anticancer medicines.

Abstract: Transfecting compounds which include an aminoglycoside linked to a lipid via a spacer, and their polyguanidylated derivatives are provided. These compounds are useful for the in vitro, ex vivo, or in vivo transfection of nucleic acids into various cell types.

Abstract: Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR′R″ grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed.

Abstract: Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR'R" grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed.

Abstract: A manhole for an urban sanitary system comprises a cover 2, a frame 1 for receiving the cover, a toric elastomeric sealing ring G1 interposed between the frame and the cover, and a soundproofing ring G2 on which the cover seats. The locking of the cover on the frame and the support of the cover on the rings G1and G2 are implemented by a plurality of flanges 4 recessed in the frame and bolted thereto.

Abstract: A mounting assembly for a take-off branch of a primary pipe 1 includes a rectangular based, tubular connection member 3 extending outwardly from the pipe through a rectangular aperture 2 in the pipe wall and having clamping tongues 3c, 3d engaging under the aperture edges on opposite sides thereof, an external gasket 4 fitted over the connection member and seating against its base and the outer surface of the pipe, and a rigid saddle 5 overlying the gasket. Four extendible tightener bolts 7, 8 are installed between the corners of the saddle and abutment supports recessed into the connection member base, and are unthreaded during installation to compress the gasket and establish a uniform seal.

Abstract: A seal assembly for axially connecting a male or spigot end 1 of a pipe T1 within a female or socket end 2 of a pipe T2 includes a radially compressed gasket G set between the outer surface of the spigot end and the inner surface of the socket, and a metal ring 3 which fits around the spigot end and bears against a lateral, inwardly facing surface 27 of an internal split metal mating flange 4, which in turn abuts internal surfaces 26, 24 on the inturned lip at the mouth of the socket. The gasket abuts the inner surface 20 of the metal ring.

Abstract: An apparatus for locking the male spigot end 2 of one pipe within the female bell housing 1 of another pipe includes a split ring 6 inserted under a radial flange 12 of the housing and a pair of clamps 16 having lugs 19 engaging mating notches 18 in the ends of the ring. The clamps are spread apart by a jack to expand the ring, whereafter they are circumferentially locked against the housing by driven wedging keys 20.

Abstract: A process for the preparation of racemic or optically active isomers of alkyl esters of cis chrysanthemic of the formula ##STR1## wherein R is alkyl of 1 to 6 carbon atoms comprising reacting a racemic or optically active cis compound of the formula ##STR2## wherein R has the above definition with an aryl halothioformate of the formula ##STR3## wherein Hal is a halogen and Ar is aryl of 6 to 12 carbon atoms optionally substituted with at least one alkyl of 1 to 3 carbon atoms to obtain a compound of the formula ##STR4## of cis configuration and heating the latter optionally in an organic solvent to obtain the compound of formula I and novel intermediates.

Abstract: A process for the preparation of racemic or optically active isomers of alkyl esters of cis chrysanthemic of the formula ##STR1## wherein R is alkyl of 1 to 6 carbon atoms comprising reacting a racemic or optically active cis compound of the formula ##STR2## wherein R has the above definition with an aryl halothioformate of the formula ##STR3## wherein Hal is a halogen and Ar is aryl of 6 to 12 carbon atoms optionally substituted with at least one alkyl of 1 to 3 carbon atoms to obtain a compound of the formula ##STR4## of cis configuration and heating the latter optionally in an organic solvent to obtain the compound of formula I and novel intermediates.