Patents by Inventor Pierre Voet

Pierre Voet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VACCINE COMPOSITION
    Publication number: 20160175423
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are characterized by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: March 2, 2016
    Publication date: June 23, 2016
    Inventors: Francois-Xavier Jacques BERTHET, Wilfried LJ DALEMANS, Philippe DENOEL, Joelle THONNARD, Christiane FERON, Jan POOLMAN, Georges THIRY, Pierre VOET, Yves LOBET, Guy DEQUESNE
  • VACCINE COMPOSITION
    Publication number: 20140294935
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: May 12, 2014
    Publication date: October 2, 2014
    Inventors: Francois-Xavier Jacques Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, George Thiry, Joelle Thonnard, Pierre Voet
  • VACCINES COMPRISING OUTER MEMBRANE VESICLES FROM GRAM NEGATIVE BACTERIA
    Publication number: 20090117147
    Abstract: The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
    Type: Application
    Filed: December 3, 2007
    Publication date: May 7, 2009
    Inventors: Francois-Xavier Jacques BERTHET, Wilfried L J. Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Nathalie Garcon, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Vaccine Composition
    Publication number: 20080233154
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: August 25, 2006
    Publication date: September 25, 2008
    Inventors: Francois-Xavier Jacques Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Vaccine composition
    Publication number: 20060216307
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: June 9, 2006
    Publication date: September 28, 2006
    Inventors: Francois-Xavier Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Hepatitis vaccines containing 3-O-deacylated monophoshoryl lipid A
    Patent number: 6893644
    Abstract: A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid. A combination vaccines including the vaccine formulation are also described.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: May 17, 2005
    Assignee: SmithKline Beecham Biologicals s.a.
    Inventors: Nathalie Marie-Josephe Claude Garcon-Johnson, Pierre Hauser, Clothilde Thiriart, Pierre Voet
  • Vaccine composition
    Publication number: 20040126389
    Abstract: The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
    Type: Application
    Filed: September 15, 2003
    Publication date: July 1, 2004
    Inventors: Francois-Xavier Jacques Berthet, Wilfried L J Dalemans, Philippe Denoel, Guy Dequesne, Chriatiane Feron, Nathalie Garcon, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Component for vaccine
    Publication number: 20040047880
    Abstract: The present invention relates to a component for a vaccine against menigococci, in particular peptides which mimic epitopes of meningococcal lipooligosaccharide, and to a vaccine comprising such a component.
    Type: Application
    Filed: September 10, 2003
    Publication date: March 11, 2004
    Inventors: Xavier Thomas De Bolle, Jean-Jacques Letesson, Yves Lobet, Pascal Yvon Mertens, Jan Poolman, Pierre Voet
  • Hepatitis vaccines containing 3-O-deacylated monophoshoryl lipid A
    Publication number: 20030211120
    Abstract: A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid A. Combination vaccines including the vaccine formulation are also described.
    Type: Application
    Filed: June 19, 2003
    Publication date: November 13, 2003
    Applicant: SmithKline Beecham Biologicals S.A.
    Inventors: Nathalie Marie-Joseph Claude Garcon-Johnson, Pierre Hauser, Clothilde Thiriart, Pierre Voet
  • Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
    Patent number: 6620414
    Abstract: A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid A. Combination vaccines including the vaccine formulation are also described.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: September 16, 2003
    Assignee: SmithKline Beecham Biologicals (s.a.)
    Inventors: Nathalie Marie-Josephe Claude Garcon-Johnson, Pierre Hauser, Clothilde Thiriart, Pierre Voet
  • Epatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
    Publication number: 20020028209
    Abstract: A vaccine formulation for the treatment or prophylaxis of hepatitis, especially hepatitis B, infections is provided comprising the hepatitis antigen and a suitable carrier such as alum in combination with 3-O-deacylated monophosphoryl lipid A. Combination vaccines including the vaccine formulation are also described.
    Type: Application
    Filed: August 21, 2001
    Publication date: March 7, 2002
    Applicant: SmithKline Beecham Biologicals sa
    Inventors: Nathalie Marie-Josephe Claude Garcon-Johnson, Pierre Hauser, Clothilde Thiriart, Pierre Voet
  • Antigens and methods therefor
    Patent number: 6103519
    Abstract: A composite particle comprising at least two polypeptides corresponding to all or part of a protein having the biological activity of one of the hepatitis B surface antigens, wherein the particle presents at least two antigenic determinants provided by the S-protein, preS2-protein or preS1-protein, said particle optionally further comprising host specific lipids. The invention also provides a modified hepatitis B surface antigen L protein which may be used alone or incorporated into such composite particles.A particular embodiment of the modified L protein (L*) comprises residues 12-52 followed by residues 133-145 followed by residues 175-400 of the L protein and a particular embodiment of a composite particle has the form (L*, S) where S is the S-protein of HBsAg.Improved hepatitis B vaccines may be prepared following expression of the above immunogens, especially in yeasts such as S. cerevisiae and Hansenula polymorpha.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: August 15, 2000
    Assignee: SmithKline Biologicals, S.A.
    Inventors: Martin Comberbach, Nigel Harford, Teresa Cabezon, Apolonia Rutgers, Pierre Voet, Eric Jacobs, Cornelis P. Hollenberg, Zbigniew A. Janowicz, Armin J. Merckelbach
  • Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A
    Patent number: 5776468
    Abstract: Novel vaccine compositions comprising small particles of 3-O-deacylated monophosphoryl lipid A are provided. In particular the particle size is below 120 nm. Such vaccine compositions have superior immunological properties.
    Type: Grant
    Filed: February 12, 1996
    Date of Patent: July 7, 1998
    Assignee: SmithKline Beecham Biologicals (S.A.)
    Inventors: Pierre Hauser, Pierre Voet, Moncef Slaoui, Nathalie Marie-Josephe Claude Garcon-Johnson, Pierre Desmons