Patents by Inventor Pierre Wils

Pierre Wils has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of a triple helix formation with an immobilized obligonucleotide
    Patent number: 8399636
    Abstract: A method for double-stranded DNA purification, by which a solution containing DNA in a mixture with other components is passed over a support on which is covalently coupled an oligonucleotide capable of hybridizing with a specific sequence present on the DNA to form a triple helix.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 19, 2013
    Assignee: Centelion
    Inventors: Joël Crouzet, Daniel Scherman, Pierre Wils, Françis Blanche, Béatrice Cameron
  • PURIFICATION OF A TRIPLE HELIX FORMATION WITH AN IMMOBILIZED OLIGONUCLEOTIDE
    Publication number: 20110319605
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Application
    Filed: August 8, 2011
    Publication date: December 29, 2011
    Applicant: Centelion
    Inventors: Joël CROUZET, Daniel Scherman, Pierre Wils, Françis Blanche, Béatrice Cameron
  • Purification of a triple helix formation with an immobilized oligonucleotide
    Patent number: 8017744
    Abstract: A method for double-stranded DNA purification, by which a solution containing DNA in a mixture with other components is passed over a support on which is covalently coupled an oligonucleotide capable of hybridizing with a specific sequence present on the DNA to form a triple helix.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: September 13, 2011
    Assignee: Centelion
    Inventors: Joël Crouzet, Daniel Scherman, Pierre Wils, Françis Blanche, Béatrice Cameron
  • PURIFICATION OF A TRIPLE HELIX FORMATION WITH AN IMMOBILIZED OLIGONUCLEOTIDE
    Publication number: 20100010208
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Application
    Filed: June 4, 2009
    Publication date: January 14, 2010
    Applicant: Centelion
    Inventors: Joël CROUZET, Daniel Scherman, Pierre Wils, Françis Blanche, Béatrice Cameron
  • Purification of a triple helix formation with an immobilized oligonucleotide
    Patent number: 7622566
    Abstract: A method for double-stranded DNA purification, by which a solution containing DNA in a mixture with other components is passed over a support on which is covalently coupled an oligonucleotide capable of hybridizing with a specific sequence present on the DNA to form a triple helix.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: November 24, 2009
    Assignee: Centelion
    Inventors: Joël Crouzet, Daniel Scherman, Pierre Wils
  • Bioengineered Vehicles for Targeted Nucleic Acid Delivery
    Publication number: 20070255041
    Abstract: There is disclosed a gene-delivery compound comprising: (A) a single-chain binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; and (B) a nucleic acid-binding moiety which is coupled to the polypeptide via the cysteinyl residue. There is disclosed also a gene-delivery compound comprising: (A) a single-chain, binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; (B) a lipid-associating moiety which is coupled to the polypeptide via the cysteinyl residue. Additionally disclosed are compositions comprising the above-mentioned compounds and a nucleic acid.
    Type: Application
    Filed: January 5, 2007
    Publication date: November 1, 2007
    Inventors: James Huston, Pierre Wils, Quan Zhu, Oliver Laurent, Wayne Marasco, Daniel Scherman
  • Purification of a triple heli formation with an immobilized oligonucleotide
    Patent number: 7038026
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: May 2, 2006
    Assignee: Centelion
    Inventors: Joël Crouzet, Daniel Scherman, Pierre Wils, Françis Blanche, Béatrice Cameron
  • Purification of a triple helix formation with an immobilized oligonucleotide
    Publication number: 20060036085
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 16, 2006
    Applicant: Centelion
    Inventors: Joel Crouzet, Daniel Scherman, Pierre Wils, Francis Blanche, Beatrice Cameron
  • Purification of plasmid DNA of pharmaceutical quality
    Patent number: 6730781
    Abstract: The invention is directed to a process for purifying double-stranded DNA, comprising using ceramic hydroxyapatite column chromatography. The invention is also directed to a purified recombinant plasmid DNA composition, comprising a chromosomal DNA content that is less than or equal to 0.01% as well as to a composition comprising DNA prepared by the foregoing process.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: May 4, 2004
    Assignee: Gencell S.A.
    Inventors: Pierre Wils, Monique Ollivier
  • Purification of a triple heli formation with an immobilized oligonucleotide
    Publication number: 20030186268
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Application
    Filed: April 7, 2003
    Publication date: October 2, 2003
    Inventors: Joel Crouzet, Daniel Scherman, Pierre Wils, Francis Blanche, Beatrice Cameron
  • Circular DNA expression cassettes for gene transfer
    Publication number: 20030104444
    Abstract: Double-stranded DNA molecules characterised in that they are circular and in that they essentially include one or more genes of interest.
    Type: Application
    Filed: September 24, 2002
    Publication date: June 5, 2003
    Applicant: Aventis Pharma S.A.
    Inventors: Joel Crouzet, Daniel Scherman, Beatrice Cameron, Pierre Wils, Anne-Marie Darquet
  • Circular DNA expression cassettes for gene transfer
    Patent number: 6492164
    Abstract: Double-stranded DNA molecules characterized in that they are circular and in that they essentially include one or more genes of interest.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: December 10, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Joël Crouzet, Daniel Scherman, Béatrice Cameron, Pierre Wils, Anne-Marie Darquet
  • Bioengineered vehicles for targeted nucleic acid delivery
    Publication number: 20020132990
    Abstract: There is disclosed a gene-delivery compound comprising: (A) a single-chain binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; and (B) a nucleic acid-binding moiety which is coupled to the polypeptide via the cysteinyl residue. There is disclosed also a gene-delivery compound comprising: (A) a single-chain, binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; (B) a lipid-associating moiety which is coupled to the polypeptide via the cysteinyl residue. Additionally disclosed are compositions comprising the above-mentioned compounds and a nucleic acid.
    Type: Application
    Filed: June 25, 2001
    Publication date: September 19, 2002
    Inventors: James S. Huston, Pierre Wils, Quan Zhu, Oliver Laurent, Wayne A. Marasco, Daniel Scherman
  • Purification of a triple helix formation with an immobilized oligonucleotide
    Patent number: 6319672
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: November 20, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Joël Crouzet, Daniel Scherman, Pierre Wils, Françis Blanche, Béatrice Cameron
  • Purification of a triple helix formation with an immobilized oligonucleotide
    Patent number: 6287762
    Abstract: Method for double-stranded DNA purification, by which a solution containing said DNA in a mixture with other components is passed over a support on which is covalently coupled in oligonucleotide capable of hybridizing with a specific sequence present on said DNA to form a triple helix.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: September 11, 2001
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Joël Crouzet, Daniel Scherman, Pierre Wils
  • Circular DNA expression cassettes for in vivo gene transfer
    Patent number: 6143530
    Abstract: Double-stranded DNA molecules characterised in that they are circular and in that they essentially include one or more genes of interest.
    Type: Grant
    Filed: August 19, 1997
    Date of Patent: November 7, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Joel Crouzet, Daniel Scherman, Beatrice Cameron, Pierre Wils, Anne-Marie Darquet