Patents by Inventor Piet de Vos

Piet de Vos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of ob gene and screening methods therefor
    Patent number: 6068976
    Abstract: This invention relates to the isolation and cloning of the promoter and other control regions of a human ob gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of an ob gene. These agents interact directly or indirectly with the promoter or other control regions of the ob gene. A PPAR.gamma. agonist, BRL49653, has been identified to be useful in treating anorexia, cachexia, and other diseases characterized by insufficient food intake or body weight loss. Modulators of ob gene expression may be used to treat other diseases such as obesity, diabetes, hypertension, cardiovascular diseases and infertility.
    Type: Grant
    Filed: March 19, 1996
    Date of Patent: May 30, 2000
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Michael R. Briggs, Johan Auwerx, Piet de Vos, Bart Staels, Glenn E. Croston, Stephen G. Miller