Patents by Inventor Piet Gros

Piet Gros has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structure of compstatin-C3 complex and use for rational drug design
    Patent number: 8442776
    Abstract: The structure of C3c in complex with the complement inhibitor, compstatin, and use of this information for rational design or identification of complement-inhibiting drugs are disclosed.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: May 14, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: John D. Lambris, Bert J. C. Janssen, Piet Gros
  • Structure Of Compstatin-C3 Complex And Use For Rational Drug Design
    Publication number: 20110060127
    Abstract: The structure of C3c in complex with the complement inhibitor, compstatin, and use of this information for rational design or identification of complement-inhibiting drugs are disclosed.
    Type: Application
    Filed: June 6, 2008
    Publication date: March 10, 2011
    Inventors: John D. Lambris, Bert J.C. Janssen, Piet Gros
  • Modulation of platelet adhesion based on the surface-exposed beta-switch loop of platelet glycoprotein IB-alpha
    Patent number: 7771724
    Abstract: The invention relates to the adhesion of platelet GpIb? to strand ?3 of domain A1 of von Willebrand factor (vWF), the strand ?3 comprising amino acid residues at amino acid position 560-566 and/or a functional part or equivalent thereof, the platelet GpIb?, the GpIb? region comprising an amino acid sequence corresponding to a beta-switch loop of platelet GpIb?, comprising amino acid residues at amino acid position 227-242 and/or a functional part or equivalent thereof. The invention provides a method of interfering with adhesion of blood platelets to vWF that includes modulating adhesion. The invention further provides proteinaceous compounds, antibodies, medicaments and pharmaceutical compositions to that end. The invention also provides means and methods to increase platelet adhesion by topical application of a compound increasing platelet adhesion.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: August 10, 2010
    Assignee: Ablynx N.V.
    Inventors: Eric Geert Huizinga, Philip Gerrit de Groot, Shizuko Tsuji, Roland Antonius Paulus Romijn, Marion Eveline Schiphorst, Jan Johannes Sixma, Piet Gros
  • Modulation platelet adhesion based on the surface-exposed beta-switch loop of platelet glycoprotein IB-alpha
    Publication number: 20050192224
    Abstract: The invention relates to the adhesion of platelet GpIb? to strand ?3 of domain A1 of von Willebrand factor (vWF), the strand ?3 comprising amino acid residues at amino acid position 560-566 and/or a functional part or equivalent thereof, the platelet GpIb?, the GpIb? region comprising an amino acid sequence corresponding to a beta-switch loop of platelet GpIb?, comprising amino acid residues at amino acid position 227-242 and/or a functional part or equivalent thereof. The invention provides a method of interfering with adhesion of blood platelets to vWF that includes modulating adhesion. The invention further provides proteinaceous compounds, antibodies, medicaments and pharmaceutical compositions to that end. The invention also provides means and methods to increase platelet adhesion by topical application of a compound increasing platelet adhesion.
    Type: Application
    Filed: February 7, 2005
    Publication date: September 1, 2005
    Inventors: Eric Huizinga, Philip de Groot, Shizuko Tsuji, Roland Romijn, Marion Schiphorst, Jan Sixma, Piet Gros