Patents by Inventor Pieter Bonsen

Pieter Bonsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Post-surgical applications for bioerodible polymers
    Patent number: 4913903
    Abstract: Applications of bioerodible polymers as surgical "leave behind" products in the areas of orthopedic, thoracic, abdominal, ocular and liver/spleen surgery.
    Type: Grant
    Filed: April 10, 1989
    Date of Patent: April 3, 1990
    Assignee: ALZA Corporation
    Inventors: Einar Sudmann, Pieter Bonsen, Eun S. Lee
  • Method of delivering drug with aid of effervescent activity generated in environment of use
    Patent number: 4344929
    Abstract: A method is disclosed for delivering a drug substantially-free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment housing (1) a drug that exhibits limited solubility under neutral and acid conditions, and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: August 17, 1982
    Assignee: ALZA Corporation
    Inventors: Pieter Bonsen, Patrick S. Wong, Felix Theeuwes
  • Method of delivering drug with aid of effervescent activity generated in environment of use
    Patent number: 4265874
    Abstract: A method is disclosed for delivering a drug substantially free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment, housing (1) a drug that exhibits limited solubility under neutral and acid conditions; and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time.
    Type: Grant
    Filed: April 25, 1980
    Date of Patent: May 5, 1981
    Assignee: Alza Corporation
    Inventors: Pieter Bonsen, Patrick S. Wong, Felix Theeuwes
  • Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
    Patent number: 4061736
    Abstract: This invention concerns pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin. The intramolecularly cross-linked, stromal-free hemoglobin is useful as a blood substitute for carrying oxygen to tissues and vital organs, as a blood plasma expander, and for supplying oxygen to oxygen-requiring environments.
    Type: Grant
    Filed: September 27, 1976
    Date of Patent: December 6, 1977
    Assignee: Alza Corporation
    Inventors: Kent C. Morris, Pieter Bonsen, Myron B. Laver
  • Compositions of matter comprising macromolecular hemoglobin
    Patent number: 4053590
    Abstract: This invention concerns polymerized, cross-linked, stromal-free hemoglobin useful as a blood substitute for carrying oxygen to tissues and organs, as a blood plasma expander and for supplying oxygen to oxygen-requiring environments.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: October 11, 1977
    Assignee: Alza Corporation
    Inventors: Pieter Bonsen, Myron B. Laver, Kent C. Morris
  • Blood substitute and blood plasma expander comprising polyhemoglobin
    Patent number: 4001401
    Abstract: This invention concerns a pharmaceutical composition comprising cross-linked, stromal-free hemoglobin mixed with a physiologically acceptable carrier useful as a blood substitute for carrying and supplying oxygen to tissues and organs, and as a blood plasma expander.
    Type: Grant
    Filed: February 27, 1975
    Date of Patent: January 4, 1977
    Assignee: Alza Corporation
    Inventors: Pieter Bonsen, Myron B. Laver, Kent C. Morris
  • Novel polymerized, cross-linked, stromal-free hemoglobin
    Patent number: 4001200
    Abstract: This invention concerns polymerized, cross-linked, stromal-free hemoglobin useful as a blood substitute for carrying oxygen to tissues and organs, as a blood plasma expander and for supplying oxygen to oxygen-requiring environments.
    Type: Grant
    Filed: February 27, 1975
    Date of Patent: January 4, 1977
    Assignee: Alza Corporation
    Inventors: Pieter Bonsen, Myron B. Laver, Kent C. Morris