Patents by Inventor Pieter H. J. Houba

Pieter H. J. Houba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy
    Patent number: 5710135
    Abstract: Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula ##STR1## as well as the acid addition salts thereof. Further the synthesis of these derivatives and their use, alone or in combination with enzymes or antibody enzyme conjugates are disclosed.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: January 20, 1998
    Assignee: Pharmachemie B.V.
    Inventors: Ruben G. G. Leenders, Eric W. P. Damen, Johan Wilhelm Scheeren, Hidde J. Haisma, Pieter H. J. Houba, Dick De Vos