Abstract: The present invention relates generally to therapy and diagnosis of depression. In particular this invention relates to the polypeptides as well as to the polynucleotides encoding these polypeptides, wherein said polypeptides are shown to play a central role in mediating the endocrine response to corticotropin releasing hormone. These polypeptides and polynucleotides are useful in the diagnosis, treatment and/or prevention of depression.

Abstract: An assembly for covering an opening comprises a movable cover having a first flexible cover part that can be wound on or off a winding tube, a second rigid cover part attached to the first cover part at the end of latter remote from the winding tube and a third flexible cover part attached to the second cover part at the end of latter remote from the first cover part, wherein the free end of the third cover part extends around a reversing member which is movable by a first driving member, which free end is connected to a second driving member, and wherein the ratio between the winding velocity V1 of the winding tube, and thus the first and second cover parts, the driving velocity V2 of the first driving member and the driving velocity V3 of the second driving member is such, that V1+V3=2V2, whereas V3>V2>V1>0.

Abstract: The present invention relates generally to therapy and diagnosis of depression. In particular this invention relates to the polypeptides as well as to the polynucleotides encoding these polypeptides, wherein said polypeptides are shown to play a central role in mediating the endocrine response to corticotropin releasing hormone. These polypeptides and polynucleotides are useful in the diagnosis, treatment and/or prevention of depression.