Patents by Inventor Pieter R. Cullis

Pieter R. Cullis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220290185
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Application
    Filed: October 28, 2021
    Publication date: September 15, 2022
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft
  • Publication number: 20210023556
    Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
    Type: Application
    Filed: October 1, 2020
    Publication date: January 28, 2021
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
  • Patent number: 10843194
    Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: November 24, 2020
    Assignee: The University of British Columbia
    Inventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
  • Patent number: 10780174
    Abstract: This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 22, 2020
    Assignee: The University of British Columbia
    Inventors: Marco A. Ciufolini, Pieter R. Cullis, Yuen Yi Tam, Joshua Zaifman
  • Patent number: 10653780
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 19, 2020
    Assignees: THE UNIVERSITY OF BRITISH COLUMBIA, ARBUTUS BIOPHARMA CORPORATION
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • Publication number: 20190307689
    Abstract: Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and, small molecule drugs, to cells.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 10, 2019
    Applicant: The University of British Columbia
    Inventors: Euan Ramsay, R. James Taylor, Colin Walsh, Nathan M. Belliveau, Pieter R. Cullis, Timothy Leaver, Andre Wild
  • Patent number: 10342760
    Abstract: Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and small molecule drugs, to cells.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 9, 2019
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Euan Ramsay, R. James Taylor, Colin Walsh, Nathan M. Belliveau, Pieter R. Cullis, Timothy Leaver, Andre Wild
  • Publication number: 20190151458
    Abstract: This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.
    Type: Application
    Filed: December 22, 2016
    Publication date: May 23, 2019
    Inventors: Marco A. Ciufolini, Pieter R. Cullis, Yuen Yi Tam, Joshua Zaifman
  • Publication number: 20190032087
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Application
    Filed: July 31, 2018
    Publication date: January 31, 2019
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft
  • Publication number: 20180280970
    Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
    Type: Application
    Filed: March 21, 2018
    Publication date: October 4, 2018
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Igor V. Jigaltsev, Robert James Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
  • Patent number: 10041091
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: August 7, 2018
    Assignee: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft, Robert James Taylor, Andre Wild, Stuart Malcolm, Ismail Hafez, Alex Leung, David Walker
  • Patent number: 9943846
    Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 17, 2018
    Assignee: The University of British Columbia
    Inventors: Pieter R. Cullis, Igor V. Jigaltsev, James R. Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
  • Publication number: 20180044699
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Application
    Filed: August 25, 2017
    Publication date: February 15, 2018
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft, Robert James Taylor, Andre Wild, Stuart Malcolm, Ismail Hafez, Alex Leung, David Walker
  • Patent number: 9758795
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: September 12, 2017
    Assignee: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft, James Taylor, Andre Wild, Stuart Malcolm, Ismail Hafez, Alex Leung, David Walker
  • Publication number: 20170121712
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Application
    Filed: January 11, 2017
    Publication date: May 4, 2017
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft, James Taylor, Andre Wild, Stuart Malcom, Ismail Hafez, Alex Leung, David Walker
  • Publication number: 20160317676
    Abstract: A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.
    Type: Application
    Filed: May 11, 2016
    Publication date: November 3, 2016
    Applicants: Tekmira Pharmaceuticals Corporation, The University of British Columbia, Acuitas Therapeutics Inc.
    Inventors: Michael J. Hope, Thomas D. Madden, Pieter R. Cullis, Martin Maier, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Akin Akinc, Muthiah Manoharan, Ismail Hafez
  • Publication number: 20160214103
    Abstract: Limit size lipid nanoparticles, methods for using the lipid nanoparticles, and methods and systems for making limit size lipid nanoparticles.
    Type: Application
    Filed: March 31, 2016
    Publication date: July 28, 2016
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Igor V. Jigaltsev, James R. Taylor, Timothy Leaver, Andre Wild, Nathan Maurice Belliveau
  • Publication number: 20160095924
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Application
    Filed: August 28, 2015
    Publication date: April 7, 2016
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, TEKMIRA PHARMACEUTICALS CORPORATION
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui
  • Publication number: 20160022580
    Abstract: Transfection reagent composition, lipid nanoparticles prepared from the transfection reagent composition, kits that include the transfection reagent composition, and methods for making and using lipid nanoparticles prepared from the transfection reagent composition. Lipids when dispersed in aqueous media readily form liposomes, such as unilamellar vesicles and multilamellar vesicles. Liposomes have been used successfully to encapsulate and deliver a wide range of chemicals including nucleic acids, proteins and. small molecule drugs, to cells.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Euan Ramsay, R. James Taylor, Colin Walsh, Nathan M. Belliveau, Pieter R. Cullis
  • Patent number: 9139554
    Abstract: The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: September 22, 2015
    Assignees: Tekmira Pharmaceuticals Corporation, The University of British Columbia
    Inventors: Michael J. Hope, Sean C. Semple, Jianxin Chen, Thomas D. Madden, Pieter R. Cullis, Marco A. Ciufolini, Barbara Low Shoud Mui