Patents by Inventor Pieter Sicco Hiemstra

Pieter Sicco Hiemstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIMICROBIAL PEPTIDES DERIVED FROM CAP18
    Publication number: 20110053835
    Abstract: The present invention relates to a group of peptidic compounds which have antimicrobial activity. The compounds also have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. The compounds can be used to manufacture medicaments useful for the treatment of bacterial or fungal infections. The medicaments may be administered systemically or locally.
    Type: Application
    Filed: September 14, 2010
    Publication date: March 3, 2011
    Applicant: OctoPlus Sciences B.V.
    Inventors: Johannes Jakobus GROTE, Jan Wouter Drijfhout, Pieter Sicco Hiemstra, Marcel Jan Vonk, Maartje Johanna Nell, Guido Vincent Bloemberg
  • Antimicrobial peptides derived from CAP18
    Patent number: 7803756
    Abstract: The invention provides methods to exert antimicrobial effects in prophylactic or therapeutic treatment of bacterial or fungal infections employing polypeptides that have affinity to microbial and fungal toxins.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: September 28, 2010
    Assignees: Octoplus Technologies B.V., Academisch Ziekenhuis Leiden
    Inventors: Johannes Jakobus Grote, Jan Wouter Drijfhout, Pieter Sicco Hiemstra, Marcel Jan Vonk, Maartje Johanna Nell, Guido Vincent Bloemberg
  • Antimicrobial Peptides Derived From Cap18
    Publication number: 20080249022
    Abstract: The present invention relates to a group of peptidic compounds which have antimicrobial activity. The compounds also have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. The compounds can be used to manufacture medicaments useful for the treatment of bacterial or fungal infections. The medicaments may be administered systemically or locally.
    Type: Application
    Filed: July 26, 2005
    Publication date: October 9, 2008
    Applicants: OCTOPLUS TECHNOLOGIES B.V., ACADEMISCH ZIEKENHUIS LEIDEN
    Inventors: Johannes Jakobus Grote, Jan Wouter Drijfhout, Pieter Sicco Hiemstra, Marcel Jan Vonk, Maartje Johanna Nell, Guido Vincent Bloemberg
  • Antimicrobial peptides derived from ubiquicidine
    Patent number: 6884776
    Abstract: The invention relates to the use of ubiquicidine or optionally modified peptide fragments derived therefrom for the preparation of a drug for the treatment, diagnostics or prophylaxis of infections in humans and animals. A peptide fragment derived from ubiquicidine comprises for instance a preferably continuous series of at least 3, preferably at least 7-13 amino acids from the amino acid sequence of ubiquicidine; KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPN ANS (SEQ ID NO: 1). Hybrid molecules comprise for instance a cationic peptide with an antimicrobial action and/or a peptide fragment of ubiquicidine and/or a derivative thereof and one or more effector molecules.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: April 26, 2005
    Assignee: RijksUniversiteit Leiden
    Inventors: Petrus Hendricus Nibbering, Pieter Sicco Hiemstra, Maria Theodora Van Den Barselaar, Ernest Karel Jacob Pauwels, Rolf Ide Johannes Feitsma