Patents by Inventor Pieter Vrijhof

Pieter Vrijhof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-14 oxidation of morphine derivatives
    Patent number: 7435817
    Abstract: The present invention relates to process for the preparation of a 14-hydroxynormorphinone derivative of formula IV comprising reacting the compound of formula III, with a cobalt (II) oxidant in the presence of a mild base and air or oxygen as the cooxidant; wherein R1 is (1C-7C)alkyl optionally substituted with one or more chlorines, butenyl, vinyl, benzyl, phenyl or naphthyl; and R2 is benzyl or benzyl substituted with one or more (1C-6C)alkoxy group or benzyl substituted with one or more halogen. The process is very suitable in the production of noroxymorphone.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: October 14, 2008
    Assignee: N.V. Organon
    Inventors: Joannes Theodorus Maria Linders, Pieter Vrijhof
  • C-14 oxidation of morphine derivatives
    Publication number: 20050038250
    Abstract: The present invention relates to process for the preparation of a 14-hydroxynormorphinone derivative of formula IV comprising reacting the compound of formula III, with a cobalt (II) oxidant in the presence of a mild base and air or oxygen as the cooxidant; wherein R1 is (1C-7C)alkyl optionally substituted with one or more chlorines, butenyl, vinyl, benzyl, phenyl or naphthyl; and R2 is benzyl or benzyl substituted with one or more (1C-6C)alkoxy group or benzyl substituted with one or more halogen. The process is very suitable in the production of noroxymorphone.
    Type: Application
    Filed: August 15, 2002
    Publication date: February 17, 2005
    Inventors: Jonnes Theodorus Maria Linders, Pieter Vrijhof
  • Method for the preparation of steroid derivative ketal
    Patent number: 6005124
    Abstract: The invention relates to a method for the preparation of a steroid derivative ketal of formula I: ##STR1## characterized in that a compound of formula II: ##STR2## is treated with an alcohol in the presence of an orthoester, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined by the specification.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: December 21, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Franciscus Theodorus Leonardus Brands, Pieter Vrijhof
  • Method for the preparation of steroid derivative ketal
    Patent number: 5955622
    Abstract: The invention relates to a method for the preparation of a compound of formula II: ##STR1## wherein a compound of formula V: ##STR2## is condensed with a compound of the formula CH.sub.3 -C(OR.sub.4 O)-(CH.sub.2).sub.3 -XHal and R.sub.1, R.sub.2, R.sub.3, R.sub.4, X and Hal are as defined by the specification.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: September 21, 1999
    Assignee: Akzo Nobel, N.V.
    Inventors: Franciscus Theodorus Leonardus Brands, Pieter Vrijhof
  • Process for the manufacture of budesonide
    Patent number: 5556964
    Abstract: The present invention relates to a novel process for the manufacture of (22 R,S)-16.alpha., 17.alpha.-butylidenedioxy-11.beta., 21-dihydroxypregna-1,4-diene-3,20 dione (I) by reacting 11.beta., 16.alpha., 17.alpha. 21-tetrahydroxypregna-1,4-diene (II) with butanal, CH.sub.3-- CH.sub.2 --CH.sub.2 --CHO, in acetonitrile in presence of p-toluenesulphonic acid as a catalyst.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: September 17, 1996
    Assignee: Aktiebolaget Astra
    Inventors: Robert G. Hofstraat, Petrus H. Raijmakers, Pieter Vrijhof