Patents by Inventor Pieter Westerduin

Pieter Westerduin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPROVED SYNTHETIC METHODS OF MAKING (2H-1, 2, 3-TRIAZOL-2-YL) PHENYL COMPOUNDS AS OREXIN RECEPTOR MODULATORS
    Publication number: 20220289754
    Abstract: Processes for preparing (((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone are described, which are useful for commercial manufacturing. Said compound is an orexin receptor modulator and may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia and depression.
    Type: Application
    Filed: August 6, 2020
    Publication date: September 15, 2022
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: DOMINIQUE PAUL M DEPRE, KIRAN MATCHA, FLORIAN DAMIEN MEDINA, PIETER WESTERDUIN, CHENG YI CHEN
  • Heparin-like derivatives
    Patent number: 5872110
    Abstract: The invention relates to carbohydrate derivatives having the formula I, ##STR1## wherein R.sup.1 is H or CH.sub.2 OSO.sub.3.sup.-, R.sup.2 and R.sup.3 are independently H, (1-6C)alkyl or SO.sub.3.sup.- ; R.sup.4 is OSO.sub.3.sup.- or NHSO.sub.3.sup.- ; n is 0 or 1; p is 1 or 2; or a pharmaceutically acceptable salt thereof The compounds of the invention have antithrombotic activity and may be used for inhibiting smooth muscle cell proliferation.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: February 16, 1999
    Assignee: Akzo Nobel N.V. and Sanofi
    Inventors: Constant Adriaan Anton Van Boeckel, Pieter Westerduin
  • Bisconjugates comprising two saccharides and a spacer
    Patent number: 5705489
    Abstract: The invention relates to a tuneable bisconjugate comprising two saccharides and a spacer, each saccharide being the same or different and comprising two to six monosaccharide units, at least one unit being uronic acid, characterized in that at least one of the saccharides per se has anti-thrombotic activity, and that the spacer connects at least one saccharide to the other through its non-reducing end, the chain length of the spacer being 20-120 atoms.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: January 6, 1998
    Assignees: Akzo Nobel N.V., Elf Sanofi
    Inventors: Constant A. A. Van Boeckel, Peter D. J. Grootenhuis, Maurice Petitou, Pieter Westerduin