Abstract: The present invention relates to compositions of recombinant polynucleic acid or RNA constructs comprising a first RNA sequence, a second RNA sequence, and a linker RNA sequence, wherein the linker RNA links the first RNA sequence and the second RNA sequence. In addition, linkers that enhance the cleavage of recombinant RNA constructs are described. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to compositions and methods for modulating expression of genes, comprising recombinant polynucleic acid or RNA constructs comprising a first RNA sequence encoding a gene of interest, and a second RNA sequence comprising at least two genetic elements that modulate expression of one or more target RNAs. The recombinant RNA constructs described herein induce an immune response in a human cell that is lower than the immune response induced by a corresponding recombinant RNA construct comprising the first RNA sequence encoding a gene of interest and a corresponding second RNA sequence comprising at most one of the at least two genetic elements. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to a mRNA and a therapeutic composition thereof for use in a method of treating lower urinary tract symptoms.

Abstract: The present invention relates to compositions of recombinant polynucleic acid constructs comprising at least one nucleic acid sequence encoding an siRNA capable of binding to a target mRNA and at least one nucleic acid sequence encoding a gene of interest. Also disclosed herein is use of the compositions in treating cancers and in simultaneously modulating expression of two or more genes.

Abstract: A gasification system that comprises a gasification reactor and a synthesis gas cooling vessel, and its use. The gasification reactor comprises a pressure shell for maintaining a pressure higher than atmospheric pressure; a slag bath located in a lower part of the pressure shell; and a gasifier wall arranged inside the pressure shell. The gasifier wall defines a gasification chamber wherein during operation the synthesis gas can be formed, a lower open part of the gasifier wall which is in fluid communication with the slag bath and an open upper end of the gasifier wall which is in fluid communication with the synthesis gas cooling vessel via a connecting conduit. The synthesis gas cooling vessel comprises an inlet for hot synthesis gas; an outlet for cooled synthesis gas; and means to directly contact liquid water with the hot synthesis gas as formed in the gasification reactor in use.

Abstract: A gasification reactor comprising a pressure shell for maintaining a pressure higher than atmospheric pressure; a slag bath located in a lower part of the pressure shell; and a gasifier wall arranged inside the pressure shell, and its use. The gasifier wall defines a gasification chamber wherein during operation a synthesis gas can be formed, a lower open part of the gasifier wall which is in fluid communication with the slag bath and an open upper end of the gasifier wall which is in fluid communication with a quench zone. The quench zone comprises a tubular formed part positioned within the pressure shell, open at its lower and upper end and having a smaller diameter than the pressure shell thereby defining an annular space around the tubular part. The lower open end of the tubular formed part is fluidly connected to the upper end of the gasifier wall and the upper open end of the tubular formed part is in fluid communication with the annular space.

Abstract: The present invention relates to a system for producing synthesis gas comprising CO and H2. The system comprises a first gasification reactor and a second gasification reactor. The first one has an inlet for a first oxygen containing stream, an inlet for a first carbonaceous stream, and an outlet for raw synthesis gas produced in the first gasification reactor. The second one has an inlet for a second oxygen containing stream, an inlet for a second carbonaceous stream, and an outlet for raw synthesis gas produced in the second gasification reactor. A source of an oxygen containing stream is selectively connected to the inlet for the first oxygen containing stream of the first gasification reactor and to the inlet for the second oxygen containing stream of the second gasification reactor via a distributor.

Abstract: A method and system for producing synthesis gas comprising CO, CO2, and H2 from a carbonaceous stream using an oxygen containing stream. A stream containing a carbonaceous material, and a stream containing oxygen are injected into a gasification reactor, where the carbonaceous stream is partially oxidised to obtain a raw synthesis gas. The raw synthesis gas is removed from the gasification reactor and directed into a quenching section wherein a liquid, preferably water, is injected in the form of a mist.

Abstract: A reactor vessel for performing a steam reforming reaction having a vessel inlet for natural gas and steam; a vessel inlet for a hot gaseous medium; a vessel outlet for the steam reforming product; and a reactor space which is a bed of steam reforming catalyst, which reactor space inlet is fluidly connected to the inlet for natural gas and steam and at its outlet end fluidly connected with the outlet for the gaseous product; wherein inside the catalyst bed a passageway is provided fluidly connected to the vessel inlet for the hot gaseous medium for passage of hot gaseous mixture counter currently to the flow of reactants in the catalyst bed.