Patents by Inventor Pietro Allevi

Pietro Allevi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for the preparation of demethylepipodophyllotoxin
    Patent number: 5688925
    Abstract: Demethylepipodophyllotoxin-.beta.-glucosides are prepared by allowing demethylepipodophyllotoxin to react with a 2,3-di-O-ester of a 1-O-trialkylsilyl-4,6-O-alkylidene-.beta.-D-glucose derivative in the presence of a Lewis acid. The 4,6-O-alkylidene group can be alkylidene, arylalkylidene, or heteroarylalkylidene and the 2,3-ester can be lower alkanoyl or haloacetyl. In a typical embodiment, demethylepipodophyllotoxin is allowed to react with 4,6-O-ethylidene-2,3-di-O-acetyl-1-O-trimethylsilyl-.beta.-D-glucose in the presence of boron trifluoride etherate to yield etoposide 2",3"-diacetate.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: November 18, 1997
    Assignee: Societa Italiana Cortico-Steroidi S.p.A.
    Inventors: Pietro Allevi, Mario Anastasia, Ettore Bigatti, Peter MacDonald