Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a heteroaryl substituted oxadiazole structure which function as non-hydroxamate histone deacetylase 6 (HDAC6) inhibitors, and their use as therapeutics for the treatment of metabolic disorders (e.g., obesity, Diabetes), neurological disorders (e.g., Alzheimer's disease, Parkinson disease, Huntington disease), cancer (e.g., multiple myeloma, biliary tract cancer, non-small cell lung cancer, chronic lymphocytic leukemia) and other conditions related to HDAC6 activity (e.g., Rett syndrome (RTT), inherited retinal disorders (IRDS), idiopathic pulmonary fibrosis (IPF), and Charcot-Marie-Tooth disease (CMT)).

Abstract: Provided herein are compounds that are potent inhibitors of the Mycobacterium tuberculosis (MTB) RNA polymerase (RNAP), which exhibit significantly reduced activation of the human pregnane X receptor (hPXR), resulting in dramatically reduced C induction of hepatic cytochromes P450 2C9 and 3A4 (CYP2C9, CYP3A4), as well as a number of Phase II metabolism enzymes. Also provided herein are pharmaceutical compositions comprising the compounds, and methods of treating tuberculosis using the compounds.

Abstract: The present invention discloses a coolant header for hot rolled strip cooling devices, which cools a hot rolled strip fed from a finish rolling mill.

Abstract: A compact collapsible gazebo includes a gazebo frame, which includes a plurality of telescoping legs, configured to rest on a ground surface and to extend and collapse. The gazebo frame also includes a plurality of side scissor structures, each comprising a plurality of scissor members and coupled to a pair of the telescoping legs, where the side scissor structures scissor together to collapse the gazebo frame and scissor apart to expand the gazebo frame. The gazebo frame also includes a plurality of central scissor structures, each having a plurality of scissor members and coupled to a central cover support and a midsection of a side scissor structure, where the central scissor structures scissor together to collapse the gazebo frame and scissor apart to expand the gazebo frame. Advantages of the invention include compactness and ease of transport of the gazebo for the gazebo user.

Abstract: The present invention relates to a dust brush, and it is an object of the present invention to provide a dust brush that minimizes the manufacture cost by manufacturing an advertising piece printed with various advertising wordings, patterns or logos, and the like on one side of a body of the dust brush, and the body which the advertising piece is detachable, as separate objects, respectively, and after mass producing the body, mounting the advertising piece thus manufactured to the body, as required. In addition, it is a further object of the present invention to provide a dust brush that its hanging becomes easy by constructing such that the latch formed at the rear end of the body can be rotated.